Extracellular matrix proteins (fibronectin, collagen III, and collagen I) immunoexpression in goat tuberculous granulomas (Mycobacterium caprae)

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dc.contributor.authorNeila, Carlos
dc.contributor.authorRebollada Merino, Agustín Miguel
dc.contributor.authorBezos Garrido, Javier
dc.contributor.authorJuan Ferré, Lucía De
dc.contributor.authorRodríguez Bertos, Antonio Manuel
dc.contributor.authorDomínguez Rodríguez, Lucas José
dc.date.accessioned2023-06-22T11:06:20Z
dc.date.available2023-06-22T11:06:20Z
dc.date.issued2022-09-22
dc.descriptionCRUE-CSIC (Acuerdos Transformativos 2022)
dc.description.abstractThe lesion resulting from the interaction between Mycobacterium and the host immune response is the tuberculous granuloma. Tuberculous granulomas, except in incipient stages, are partially or totally encapsulated by connective tissue. The aim of this study was to assess the immunoexpression of the extracellular matrix proteins fibronectin, collagen III, and collagen I in granulomas caused by Mycobacterium caprae in goats (Capra aegagrus hircus) to understand capsule development at diferent granuloma stages. For this purpose, a retrospective study of 56 samples of tuberculous granulomas in lung (n=30) and mediastinal lymph node (n=26) from 17 goats naturally infected with M. caprae in stages I (n=15), II (n=14) and III (n=27) was carried out. Fibronectin immunoreaction was extracellular, fibrillar-reticular in the center of stage I, II and III granulomas and peripheral in stages II and III granulomas. Collagen III immunoexpression was extracellular and fibrillar in the center of stages I, II and III tuberculous granulomas in lung and mediastinal lymph node, and progressive expression was observed in the periphery of stages II and III granulomas. Finally, collagen I immunoexpression was extracellular and fibrillar, showing a progressive loss of central expression and an increase in peripheral expression in stage III granulomas compared to stage I granulomas. Immunoexpression of these extracellular matrix proteins could help understand fibrogenesis and dating in tuberculous granuloma in both animal models and humans.
dc.description.departmentDepto. de Medicina y Cirugía Animal
dc.description.departmentDepto. de Sanidad Animal
dc.description.facultyFac. de Veterinaria
dc.description.facultyCentro de Vigilancia Sanitaria Veterinaria (VISAVET)
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Ciencia e Innovación (MICINN)
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/74908
dc.identifier.doi10.1007/s11259-022-09996-3
dc.identifier.issn0165-7380
dc.identifier.officialurlhttps://doi.org/10.1007/s11259-022-09996-3
dc.identifier.urihttps://hdl.handle.net/20.500.14352/72109
dc.journal.titleVeterinary Research Communications
dc.language.isoeng
dc.publisherSpringer Nature
dc.relation.projectID(RTI2018–098658-BC22; PRE2019–087439)
dc.rightsAtribución 3.0 España
dc.rights.accessRightsopen access
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/es/
dc.subject.keywordCollagen
dc.subject.keywordFibronectin
dc.subject.keywordFibrosis
dc.subject.keywordMycobacterium caprae
dc.subject.keywordTuberculous granuloma
dc.subject.ucmSanidad animal
dc.titleExtracellular matrix proteins (fibronectin, collagen III, and collagen I) immunoexpression in goat tuberculous granulomas (Mycobacterium caprae)
dc.typejournal article
dspace.entity.typePublication
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relation.isAuthorOfPublication.latestForDiscovery2e80b9e6-3809-4756-9ef8-ebc9ce005eb8
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