Whole Alga, Algal Extracts, and Compounds as Ingredients of Functional Foods: Composition and Action Mechanism Relationships in the Prevention and Treatment of Type-2 Diabetes Mellitus

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dc.contributor.authorBocanegra De Juana, Aranzazu
dc.contributor.authorMacho González, Adrián
dc.contributor.authorGarcimartín Álvarez, Alba
dc.contributor.authorBenedí González, Juana María
dc.contributor.authorSánchez Muniz, Francisco José
dc.date.accessioned2023-06-17T08:33:21Z
dc.date.available2023-06-17T08:33:21Z
dc.date.issued2021-04-07
dc.description.abstractType-2 diabetes mellitus (T2DM) is a major systemic disease which involves impaired pancreatic function and currently affects half a billion people worldwide. Diet is considered the cornerstone to reduce incidence and prevalence of this disease. Algae contains fiber, polyphenols, ω-3 PUFAs, and bioactive molecules with potential antidiabetic activity. This review delves into the applications of algae and their components in T2DM, as well as to ascertain the mechanism involved (e.g., glucose absorption, lipids metabolism, antioxidant properties, etc.). PubMed, and Google Scholar databases were used. Papers in which whole alga, algal extracts, or their isolated compounds were studied in in vitro conditions, T2DM experimental models, and humans were selected and discussed. This review also focuses on meat matrices or protein concentrate-based products in which different types of alga were included, aimed to modulate carbohydrate digestion and absorption, blood glucose, gastrointestinal neurohormones secretion, glycosylation products, and insulin resistance. As microbiota dysbiosis in T2DM and metabolic alterations in different organs are related, the review also delves on the effects of several bioactive algal compounds on the colon/microbiota-liver-pancreas-brain axis. As the responses to therapeutic diets vary dramatically among individuals due to genetic components, it seems a priority to identify major gene polymorphisms affecting potential positive effects of algal compounds on T2DM treatment.
dc.description.departmentDepto. de Farmacología, Farmacognosia y Botánica
dc.description.facultyFac. de Farmacia
dc.description.refereedTRUE
dc.description.sponsorshipSpanish Ministry of Education, Culture and Sports (FPU15/02759). Adrián Macho-González received a predoctoral fellowship
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/78107
dc.identifier.doi10.3390/ijms22083816
dc.identifier.issn1422-0067
dc.identifier.officialurlhttps://www.mdpi.com/journal/ijms
dc.identifier.urihttps://hdl.handle.net/20.500.14352/7431
dc.issue.number8
dc.journal.titleInternational Journal of Molecular Sciences
dc.language.isoeng
dc.page.initial3816
dc.publisherMDPI
dc.relation.projectIDPID2019-103872RB-I00
dc.rightsAtribución 3.0 España
dc.rights.accessRightsopen access
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/es/
dc.subject.cdu615.322
dc.subject.cdu616.379-008.64
dc.subject.keywordAlgae
dc.subject.keywordDiabetes
dc.subject.keywordFunctional food
dc.subject.keywordFunctional meat
dc.subject.keywordMicrobiota
dc.subject.keywordMetabolism
dc.subject.ucmGastroenterología y hepatología
dc.subject.ucmFarmacología (Farmacia)
dc.subject.unesco3205.03 Gastroenterología
dc.subject.unesco3209 Farmacología
dc.titleWhole Alga, Algal Extracts, and Compounds as Ingredients of Functional Foods: Composition and Action Mechanism Relationships in the Prevention and Treatment of Type-2 Diabetes Mellitus
dc.typejournal article
dc.volume.number22
dspace.entity.typePublication
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relation.isAuthorOfPublication.latestForDiscovery90f4565e-c57c-49be-aea1-545ea0d88bb4
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