Tumor progression locus 2 (TPL2): A Cot-plicated progression from inflammation to chronic liver disease

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dc.contributor.authorHionides Gutiérrez, Alejandro
dc.contributor.authorMazariegos, Marina S.
dc.contributor.authorAlemany, Susana
dc.contributor.authorNevzorova, Yulia
dc.contributor.authorCubero Palero, Francisco Javier
dc.contributor.authorSanz García, Carlos
dc.date.accessioned2024-02-13T13:43:53Z
dc.date.available2024-02-13T13:43:53Z
dc.date.issued2023
dc.description.abstractThe cytoplasmic protein tumor progression locus 2 (TPL2), also known as cancer Osaka thyroid (Cot), or MAP3K8, is thought to have a significant role in a variety of cancers and illnesses and it is a key component in the activation pathway for the expression of inflammatory mediators. Despite the tight connection between inflammation and TPL2, its function has not been extensively studied in chronic liver disease (CLD), a major cause of morbidity and mortality worldwide. Here, we analyze more in detail the significance of TPL2 in CLD to shed light on the pathological and molecular transduction pattern of TPL2 during the progression of CLD. This might result in important advancements and enable progress in the diagnosis and treatment of CLD.
dc.description.departmentDepto. de Inmunología, Oftalmología y ORL
dc.description.facultyFac. de Medicina
dc.description.refereedTRUE
dc.description.sponsorshipComunidad de Madrid
dc.description.sponsorshipMinisterio de Ciencia e Innovación (España)
dc.description.sponsorshipEuropean Commission
dc.description.statuspub
dc.identifier.citationGutierrez AH, Mazariegos MS, Alemany S, Nevzorova YA, Cubero FJ, Sanz-García C. Tumor progression locus 2 (TPL2): A Cot-plicated progression from inflammation to chronic liver disease. Biochim Biophys Acta Mol Basis Dis. 2023 Apr;1869(4):166660. doi: 10.1016/j.bbadis.2023.166660. Epub 2023 Feb 8. PMID: 36764206.
dc.identifier.doi10.1016/j.bbadis.2023.166660
dc.identifier.issn0925-4439
dc.identifier.officialurlhttps://doi.org/10.1016/j.bbadis.2023.166660
dc.identifier.pmid36764206
dc.identifier.relatedurlhttps://pubmed.ncbi.nlm.nih.gov/36764206/
dc.identifier.urihttps://hdl.handle.net/20.500.14352/101373
dc.issue.number4
dc.journal.titleBBA - Molecular Basis of Disease
dc.language.isoeng
dc.publisherElsevier
dc.relation.projectIDPID2020-113299RA-I00
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-117827RB-I00/ES/INTERVENCION TERAPEUTICA EN UN NUEVO MODELO EXPERIMENTAL DE ESTEATOHEPATITIS ALCOHOLICA Y NO-ALCOHOLICA (BASH): RELEVANCIA DEL EJE INTESTINO-HIGADO /
dc.relation.projectIDPID2020-117941RB-I00
dc.relation.projectIDPID2020-116146RB-I00
dc.relation.projectIDHORIZON-HLTH-2022-STAYHLTH-02
dc.relation.projectID2019-T1/BMD-13313
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.cdu616-006.04
dc.subject.cdu612.017
dc.subject.keywordMAPK
dc.subject.keywordCancer osaka thyroid
dc.subject.keywordTumor progression locus- 2
dc.subject.keywordcancer
dc.subject.keywordinflammation
dc.subject.keywordchronic liver disease
dc.subject.ucmCiencias Biomédicas
dc.subject.ucmInmunología
dc.subject.unesco24 Ciencias de la Vida
dc.subject.unesco2412 Inmunología
dc.titleTumor progression locus 2 (TPL2): A Cot-plicated progression from inflammation to chronic liver disease
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number1869
dspace.entity.typePublication
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relation.isAuthorOfPublicationb3877679-0fbd-42e6-8541-1efeb2df768a
relation.isAuthorOfPublicationdbd5c193-0989-4230-856f-f19260f3c894
relation.isAuthorOfPublication.latestForDiscovery5f15ba54-984a-437d-899a-14563423e77e

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