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Diagnostic performance of inflammatory biomarkers and cytological analysis in salivary gland tumors

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dc.contributor.authorAbbate, Vincenzo
dc.contributor.authorBarone, Simona
dc.contributor.authorBorriello, Gerardo
dc.contributor.authorTroise, Stefania
dc.contributor.authorBonavolontá, Paola
dc.contributor.authorPacella, Daniela
dc.contributor.authorVaira, Luigi Angelo
dc.contributor.authorTurri Zanoni, Mario
dc.contributor.authorNavarro Cuéllar, Carlos
dc.contributor.authorCalifano, Luigi
dc.contributor.authorDell' Aversana Orabona, Giovanni
dc.date.accessioned2024-09-05T09:13:06Z
dc.date.available2024-09-05T09:13:06Z
dc.date.issued2023-09-26
dc.description.abstractBackground This study aimed to evaluate the diagnostic performance of serum inflammatory biomarkers in salivary gland tumors with dubious results following cytological analysis. Methods A retrospective analysis of 239 cases following surgery between January 2011 and June 2022 was performed. Receiver Operating Characteristic curves were drawn and areas under the curves were computed to evaluate the diagnostic performance of the inflammatory biomarkers (SII, SIRI, PLR, and NLR). Optimal cut-offs for each marker were determined by maximizing the Youden index. Results Analysis showed that among the major biomarkers examined, SIRI performed an AUC of 0.77. The best SIRI cut-off was 0.94 with an accuracy of 79.9%. The accuracy, sensitivity, and specificity of cytological analysis were 77.8%, 59.6%, and 90.7% respectively. By combining SIRI with cytological analysis we demonstrated an increase in sensitivity to 82.8%. Conclusions Inflammatory biomarkers could be evaluated to support the diagnosis and treatment of salivary gland tumors in difficult cases.
dc.description.departmentDepto. de Cirugía
dc.description.facultyFac. de Medicina
dc.description.fundingtypeAPC financiada por la UCM
dc.description.refereedTRUE
dc.description.statuspub
dc.identifier.citationAbbate V, Barone S,Borriello G, et al. Diagnostic performance ofinflammatory biomarkers and cytological analysisin salivary gland tumors. Head & Neck. 2023;45(12):3015‐3023. doi:10.1002/hed.27528ABBATE ET AL . 3023
dc.identifier.doi10.1002/hed.27528
dc.identifier.essn1097-0347
dc.identifier.issn1043-3074
dc.identifier.officialurlhttps://doi.org/10.1002/hed.27528
dc.identifier.relatedurlhttps://onlinelibrary.wiley.com/doi/10.1002/hed.27528
dc.identifier.urihttps://hdl.handle.net/20.500.14352/107939
dc.issue.number12
dc.journal.titleHead and Neck
dc.language.isoeng
dc.page.final3023
dc.page.initial3015
dc.publisherWiley
dc.rightsAttribution 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.cdu617
dc.subject.ucmCiencias Biomédicas
dc.subject.unesco32 Ciencias Médicas
dc.titleDiagnostic performance of inflammatory biomarkers and cytological analysis in salivary gland tumors
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number45
dspace.entity.typePublication
relation.isAuthorOfPublication546ee3a8-8426-4aa9-8814-c8ce8cdeacff
relation.isAuthorOfPublication.latestForDiscovery546ee3a8-8426-4aa9-8814-c8ce8cdeacff

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