Cocrystallization of the anticancer drug 5-fluorouracil and coformers urea, thiourea or pyrazinamide using supercritical CO2 as an antisolvent (SAS) and as a solvent (CSS)

Simple item page
dc.contributor.authorCuadra Mendoza, Isaac Alfonso
dc.contributor.authorCabañas Poveda, Albertina
dc.contributor.authorRodríguez Cheda, José Antonio
dc.contributor.authorTürk, MIchael
dc.contributor.authorPando García-Pumarino, Concepción
dc.date.accessioned2024-01-16T18:44:44Z
dc.date.available2024-01-16T18:44:44Z
dc.date.issued2020
dc.description.abstractCo-crystals of 5-fluorouracil (5-Fu) and the coformers urea, thiourea and pyrazinamide (PZA) were attempted for the first time through the supercritical antisolvent (SAS) and the cocrystallization with supercritical solvent (CSS) techniques. SAS operational conditions were temperature (313 K), pressure (7.0–15.0 MPa) and 5-Fu concentration in methanol (5 and 2.5 mg/mL). Coformer concentration was always in the desired stoichiometric ratio. Co-crystals were characterized using powder X-ray diffraction (PXRD), differential scanning calorimetry (DSC), infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). Pure 5-Fu-urea cocrystals were obtained via SAS at 313 K and 8.0 MPa using a 5 mg/mL 5-Fu solution. All other SAS conditions studied led to 5-Fu homocrystal impurities. For comparison purposes 5-Fu, urea and thiourea were also processed by SAS. CSS produced a mixture of co-crystals and homocrystals only when supercritical CO2 was modified with methanol. Advantages and disadvantages of the two supercritical cocrystallization techniques are discussed.
dc.description.departmentDepto. de Química Física
dc.description.facultyFac. de Ciencias Químicas
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Economía y Competitividad (España)
dc.description.sponsorshipUniversidad Complutense de Madrid
dc.description.statuspub
dc.identifier.citationIsaac A. Cuadra, Albertina Cabañas, José A.R. Cheda, Michael Türk, Concepción Pando, Cocrystallization of the anticancer drug 5-fluorouracil and coformers urea, thiourea or pyrazinamide using supercritical CO2 as an antisolvent (SAS) and as a solvent (CSS), The Journal of Supercritical Fluids, Volume 160, 2020, 104813
dc.identifier.doi10.1016/j.supflu.2020.104813
dc.identifier.issn0896-8446
dc.identifier.officialurlhttps://doi.org/10.1016/j.supflu.2020.104813
dc.identifier.relatedurlhttps://www.sciencedirect.com/science/article/pii/S0896844620300644?via%3Dihub
dc.identifier.urihttps://hdl.handle.net/20.500.14352/93480
dc.journal.titleThe Journal of Supercritical Fluids
dc.language.isoeng
dc.page.initial104813
dc.publisherElsevier
dc.relation.projectIDRTI2018-097230-B-I00 y UCM-Santander PR75/18-21583
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.accessRightsembargoed access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.cdu547
dc.subject.cdu615.01/.03
dc.subject.cdu66
dc.subject.keywordCarbon dioxide
dc.subject.keywordPharmaceutical co-crystals
dc.subject.keywordSupercritical antisolvent
dc.subject.keywordCocrystallization with supercritical solvent
dc.subject.keyword5-fluorouracil
dc.subject.ucmQuímica física (Química)
dc.subject.ucmFarmacología (Farmacia)
dc.subject.ucmMateriales
dc.subject.ucmIngeniería química
dc.subject.unesco2307 Química Física
dc.subject.unesco23 Química
dc.subject.unesco3209 Farmacología
dc.subject.unesco3303 Ingeniería y Tecnología Químicas
dc.titleCocrystallization of the anticancer drug 5-fluorouracil and coformers urea, thiourea or pyrazinamide using supercritical CO2 as an antisolvent (SAS) and as a solvent (CSS)
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number160
dspace.entity.typePublication
relation.isAuthorOfPublication8eb44b53-53de-4d6e-9339-2f0c957e5867
relation.isAuthorOfPublication08f9e67b-e7ba-420b-a651-37a03ba04f0c
relation.isAuthorOfPublicationd18bd0a3-b2d5-47ce-bbdc-e2cdad66ac80
relation.isAuthorOfPublication14dc7f21-ee73-46a9-accd-f5a648b5bc0b
relation.isAuthorOfPublication.latestForDiscovery14dc7f21-ee73-46a9-accd-f5a648b5bc0b
Download
Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Cocrystalization.pdf
Size:
5.04 MB
Format:
Adobe Portable Document Format
Download
Collections
Artículos