Role of instrumental factors in Meibomian gland contrast assessment

Simple item page
dc.contributor.authorDiz Arias, Elena
dc.contributor.authorFernández Jiménez, Elena
dc.contributor.authorPeral Cerda, María Asunción
dc.contributor.authorGómez Pedrero, José Antonio
dc.date.accessioned2023-06-22T12:59:34Z
dc.date.available2023-06-22T12:59:34Z
dc.date.issued2023-04-26
dc.description.abstractPurpose: Meibomian gland contrast has been suggested as a potential biomarker in Meibomian gland dysfunction. This study analysed the instrumental factors related to contrast. The objectives were to determine whether the mathematical equations used to compute gland contrast (e.g., Michelson or Yeh and Lin), impact the ability to identify abnormal individuals, to ascertain whether contrast between the gland and the background could be an effective biomarker and to assess whether using contrast-enhancement on the gland image improves its diagnostic efficacy. Methods: A total of 240 meibography images from 40 participants (20 controls and 20 having Meibomian gland dysfunction or blepharitis), were included. The Oculus Keratograph 5M was used to capture images from the upper and lower eyelids of each eye. The contrast of unprocessed images and those pre-processed with contrast-enhancement algorithms were analysed. Contrast was measured on the eight central glands. Two equations for contrast computation were used, and the contrast both between glands and within a gland were calculated. Results: Significant differences were found between the groups for inter-gland area in the upper (p = 0.01) and lower eyelids (p = 0.001) for contrast measured with the Michelson formula. Similar effects were observed when using the Yeh and Lin method in the upper (p = 0.01) and lower eyelids (p = 0.04). These results were obtained for images enhanced with the Keratograph 5M algorithm. Conclusions: Meibomian gland contrast is a useful biomarker of disease related to the Meibomian glands. Contrast measurement should be determined using contrast-enhanced images in the inter-gland area. However, the method used to compute contrast did not influence the results.en
dc.description.departmentSección Deptal. de Óptica (Óptica)
dc.description.departmentDepto. de Optometría y Visión
dc.description.facultyFac. de Óptica y Optometría
dc.description.refereedTRUE
dc.description.sponsorshipFondo Europeo de Desarrollo Regional
dc.description.sponsorshipAgencia Estatal de Investigación (España)
dc.description.sponsorshipUniversidad Complutense de Madrid
dc.description.sponsorshipBanco Santander
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/77947
dc.identifier.citationDiz Arias, E., Fernández Jiménez, E., Peral Cerda, M. A., Gómez Pedrero, J. A. «Role of Instrumental Factors in Meibomian Gland Contrast Assessment». Ophthalmic and Physiological Optics, vol. 43, n.o 5, septiembre de 2023, pp. 1050-58. DOI.org (Crossref), https://doi.org/10.1111/opo.13156.
dc.identifier.doi10.1111/opo.13156
dc.identifier.issn0275-5408
dc.identifier.officialurlhttps://doi.org/10.1111/opo.13156
dc.identifier.relatedurlhttps://onlinelibrary.wiley.com/doi/full/10.1111/opo.13156
dc.identifier.urihttps://hdl.handle.net/20.500.14352/73396
dc.journal.titleOphthalmic and Physiological Optics
dc.language.isoeng
dc.page.initial9 p.
dc.publisherWILEY-BLACKWELL Publishing
dc.relation.projectIDDPI2016-75272-R
dc.rightsAtribución-NoComercial 3.0 España
dc.rights.accessRightsopen access
dc.rights.urihttps://creativecommons.org/licenses/by-nc/3.0/es/
dc.subject.cdu617.764.1-073
dc.subject.cdu616-074:543.645
dc.subject.keywordMeibomian gland dysfunction
dc.subject.keywordMeibomian glands
dc.subject.keywordBiomarker
dc.subject.keywordContrast
dc.subject.keywordMeibography
dc.subject.ucmOftalmología
dc.subject.ucmAnatomía ocular
dc.subject.ucmTécnicas de la imagen
dc.subject.unesco3201.09 Oftalmología
dc.titleRole of instrumental factors in Meibomian gland contrast assessmenten
dc.typejournal article
dspace.entity.typePublication
relation.isAuthorOfPublication2e2e6002-6583-4a52-9358-ef4606e42d75
relation.isAuthorOfPublication2b3052fa-b98a-44f3-a982-f01bccb83c6a
relation.isAuthorOfPublication5c5cb6be-771c-40ed-8af0-cdfdbdfb3d36
relation.isAuthorOfPublication.latestForDiscovery2e2e6002-6583-4a52-9358-ef4606e42d75
Download
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Ophthalmic Physiologic Optic - 2023 - Diz‐Arias - Role of instrumental factors in Meibomian gland contrast assessment.pdf
Size:
4.19 MB
Format:
Adobe Portable Document Format
downoload Download
Collections
Artículos