Effect of Hypercholesterolemia, Systemic Arterial Hypertension and Diabetes Mellitus on Peripapillary and Macular Vessel Density on Superficial Vascular Plexus in Glaucoma

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dc.contributor.authorSanz Gomez, María
dc.contributor.authorZeng, Ni
dc.contributor.authorCatagna Catagna, Gloria Estefania
dc.contributor.authorArribas Pardo, Paula
dc.contributor.authorGarcía Feijoo, Julián
dc.contributor.authorMéndez Hernández, Carmen Dora
dc.date.accessioned2023-06-22T11:14:13Z
dc.date.available2023-06-22T11:14:13Z
dc.date.issued2023-02-06
dc.description1 Department of Inmunology Ophthalmology and ORL, IIORC, Complutense University of Madrid, 28232 Madrid, Spain 2 Ophthalmology Department, Central Defense Hospital “Gomez Ulla”, 28047 Madrid, Spain 3 Ophthalmology Department, Hospital Clínico San Carlos, Institute of Health Research (IdISSC), 28232 Madrid, Spain
dc.description.abstractBackground/Aims: Vascular factors are involved in the development of glaucoma, including diseases such as hypercholesterolemia (HC), systemic arterial hypertension (SAH), and diabetes mellitus (DM). The aim of this study was to determine the effect of glaucoma disease on peripapillary vessel density (sPVD) and macular vessel density (sMVD) on the superficial vascular plexus, controlling differences on comorbidities such as SAH, DM and HC between glaucoma patients and normal subjects. Methods: In this prospective, unicenter, observational cross-sectional study, sPVD and sMVD were measured in 155 glaucoma patients and 162 normal subjects. Differences between normal subjects and glaucoma patients’ groups were analyzed. A linear regression model with 95% confidence and 80% statistical power was performed. Results: Parameters with greater effect on sPVD were glaucoma diagnosis, gender, pseudophakia and DM. Glaucoma patients had a sPVD 1.2% lower than healthy subjects (Beta slope 1.228; 95%CI 0.798–1.659, p < 0.0001). Women presented 1.19% more sPVD than men (Beta slope 1.190; 95%CI 0.750–1.631, p < 0.0001), and phakic patients presented 1.7% more sPVD than men (Beta slope 1.795; 95%CI 1.311–2.280, p < 0.0001). Furthermore, DM patients had 0.9% lower sPVD than non-diabetic patients (Beta slope 0.925; 95%CI 0.293–1.558, p = 0.004). SAH and HC did not affect most of the sPVD parameters. Patients with SAH and HC showed 1.5% lower sMVD in the outer circle than subjects without those comorbidities (Beta slope 1.513; 95%CI 0.216–2.858, p = 0.021 and 1.549; 95%CI 0.240–2.858, p = 0.022 respectively. Conclusions: Glaucoma diagnosis, previous cataract surgery, age and gender seem to have greater influence than the presence of SAH, DM and HC on sPVD and sMVD, particularly sPVD.
dc.description.departmentDepto. de Inmunología, Oftalmología y ORL
dc.description.facultyFac. de Medicina
dc.description.refereedTRUE
dc.description.sponsorshipDepartment of Inmunology Ophthalmology and ORL, IIORC, Complutense University of Madrid, 28232 Madrid, Spain
dc.description.sponsorshipOphthalmology Department, Central Defense Hospital “Gomez Ulla”, 28047 Madrid, Spain
dc.description.sponsorshipOphthalmology Department, Hospital Clínico San Carlos, Institute of Health Research (IdISSC), 28232 Madrid, Spain
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/78215
dc.identifier.doi10.3390/jcm12052071
dc.identifier.issn2077-0383
dc.identifier.urihttps://hdl.handle.net/20.500.14352/72235
dc.issue.number5
dc.journal.titleJournal of Clinical Medicine
dc.language.isoeng
dc.page.initial2071
dc.publisherMDPI
dc.rightsAtribución 3.0 España
dc.rights.accessRightsopen access
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/es/
dc.subject.cdu617.7
dc.subject.cdu617.7-007.681
dc.subject.cdu616.379-008.64-06
dc.subject.cdu616.12-008.331.1
dc.subject.keywordGlaucoma
dc.subject.keywordOCTA
dc.subject.keywordOCT
dc.subject.keywordPeripapillary vessel density
dc.subject.ucmMedicina
dc.subject.ucmOftalmología
dc.subject.unesco32 Ciencias Médicas
dc.subject.unesco3201.09 Oftalmología
dc.titleEffect of Hypercholesterolemia, Systemic Arterial Hypertension and Diabetes Mellitus on Peripapillary and Macular Vessel Density on Superficial Vascular Plexus in Glaucoma
dc.typejournal article
dc.volume.number12
dspace.entity.typePublication
relation.isAuthorOfPublication558b8023-6d72-4dff-9f99-2e60f6f31843
relation.isAuthorOfPublication533dd90f-2b34-4a5f-9cf8-ab8d19454edd
relation.isAuthorOfPublication.latestForDiscovery558b8023-6d72-4dff-9f99-2e60f6f31843
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