Colonic bacterial translocation as a possible factor in stress-worsening experimental stroke outcome

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dc.contributor.authorCaso Fernández, Javier Rubén
dc.contributor.authorHurtado Moreno, Olivia
dc.contributor.authorPereira, Marta P.
dc.contributor.authorGarcía Bueno, Borja
dc.contributor.authorMenchén Viso, Luis Alberto
dc.contributor.authorAlou Cervera, Luis
dc.contributor.authorGómez-Lus Centelles, María Luisa
dc.contributor.authorMoro Sánchez, María Ángeles
dc.contributor.authorLizasoaín Hernández, Ignacio
dc.contributor.authorLeza Cerro, Juan Carlos
dc.date.accessioned2024-07-24T12:41:58Z
dc.date.available2024-07-24T12:41:58Z
dc.date.issued2009-04
dc.description.abstractStress is known to be one of the risk factors of stroke, but only a few experimental studies have examined the possible mechanisms by which prior stress may affect stroke outcome. In stroke patients, infections impede neurological recovery and increase morbidity as well as mortality. We previously reported that stress induces a bacterial translocation and that prior immobilization stress worsens experimental stroke outcome through mechanisms that involve inflammatory mediators such as release of proinflammatory cytokines and enzyme activation. We now investigate whether bacterial translocation from the intestinal flora of rats with stress before experimental ischemia is involved in stroke outcome. We used an experimental paradigm consisting of exposure of Fischer rats to repeated immobilization sessions before permanent middle cerebral artery occlusion (MCAO). The presence of bacteria and the levels and expression of different mediators involved in the bacterial translocation were analyzed. Our results indicate that stress before stroke is related to the presence of bacteria in different organs (mesenteric nodes, spleen, liver, and lung) after MCAO and increases inflammatory colonic parameters (such as cyclooxygenase-2, inducible nitric oxide synthase, and myeloperoxidase), but decreases colonic immunoglobulin A, and these results are correlated with colonic inflammation and bacterial translocation. Understanding the implication of bacterial translocation during stress-induced stroke worsening is of great potential clinical relevance, given the high incidence of infections after severe stroke and their main role in mortality and morbidity in stroke patients.
dc.description.departmentDepto. de Farmacología y Toxicología
dc.description.departmentDepto. de Medicina
dc.description.facultyFac. de Medicina
dc.description.refereedTRUE
dc.description.statuspub
dc.identifier.citationCaso JR, Hurtado O, Pereira MP, García-Bueno B, Menchén L, Alou L, Gómez-Lus ML, Moro MA, Lizasoain I, Leza JC. Colonic bacterial translocation as a possible factor in stress-worsening experimental stroke outcome. Am J Physiol Regul Integr Comp Physiol. 2009 Apr;296(4):R979-85.
dc.identifier.doi10.1152/ajpregu.90825.2008
dc.identifier.essn1522-1490
dc.identifier.issn0363-6119
dc.identifier.officialurlhttps://doi.org/10.1152/ajpregu.90825.2008
dc.identifier.relatedurlhttps://journals.physiology.org/doi/full/10.1152/ajpregu.90825.2008
dc.identifier.urihttps://hdl.handle.net/20.500.14352/107128
dc.issue.number4
dc.journal.titleAmerican Journal of Physiology-Regulatory, Integrative and Comparative Physiology
dc.language.isoeng
dc.page.finalR985
dc.page.initialR979
dc.publisherAmerican Physiological Society
dc.rights.accessRightsrestricted access
dc.subject.cdu611.02
dc.subject.cdu615
dc.subject.keywordstress
dc.subject.keywordstroke
dc.subject.keywordbacterial translocation
dc.subject.keywordintestinal barrier
dc.subject.keywordstroke outcome
dc.subject.ucmFarmacología (Medicina)
dc.subject.ucmMicrobiología médica
dc.subject.unesco2414 Microbiología
dc.subject.unesco3209 Farmacología
dc.titleColonic bacterial translocation as a possible factor in stress-worsening experimental stroke outcome
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number296
dspace.entity.typePublication
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