Long-term effects of intermittent adolescent alcohol exposure in male and female rats

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dc.contributor.authorMarco López, Eva María
dc.contributor.authorPeñasco, Sara
dc.contributor.authorHernández, María Donina
dc.contributor.authorGil, Anabel
dc.contributor.authorBorcel, Erika
dc.contributor.authorMoya, Marta
dc.contributor.authorGiné Domínguez, Elena
dc.contributor.authorLópez Moreno, José Antonio
dc.contributor.authorGuerri, Consuelo
dc.contributor.authorLópez Gallardo, Meritxell
dc.contributor.authorRodríguez de Fonseca, Fernando
dc.date.accessioned2023-06-17T22:23:22Z
dc.date.available2023-06-17T22:23:22Z
dc.date.issued2017
dc.description.abstractAlcohol is a serious public health concern that has a differential impact on individuals depending upon age and sex. Patterns of alcohol consumption have recently changed: heavy episodic drinking—known as binge-drinking—has become most popular among the youth. Herein, we aimed to investigate the consequences of intermittent adolescent alcohol consumption in male and female animals. Thus, Wistar rats were given free access to ethanol (20% in drinking water) or tap water for 2-h sessions during 3 days, and for an additional 4-h session on the 4th day; every week during adolescence, from postnatal day (pnd) 28–52. During this period, animals consumed a moderate amount of alcohol despite blood ethanol concentration (BEC) did not achieve binge-drinking levels. No withdrawal signs were observed: no changes were observed regarding anxiety-like responses in the elevated plus-maze or plasma corticosterone levels (pnd 53–54). In the novel object recognition (NOR) test (pnd 63), a significant deficit in recognition memory was observed in both male and female rats. Western Blot analyses resulted in an increase in the expression of synaptophysin in the frontal cortex (FC) of male and female animals, together with a decrease in the expression of the CB2R in the same brain region. In addition, adolescent alcohol induced, exclusively among females, a decrease in several markers of dopaminergic and serotonergic neurotransmission, in which epigenetic mechanisms, i.e., histone acetylation, might be involved. Taken together, further research is still needed to specifically correlate sex-specific brain and behavioral consequences of adolescent alcohol exposure.
dc.description.departmentDepto. de Genética, Fisiología y Microbiología
dc.description.facultyFac. de Ciencias Biológicas
dc.description.refereedTRUE
dc.description.sponsorshipInstituto de Salud Carlos III (ISC-III) and European Regional Development Funds European Union (ERDF-EU)
dc.description.sponsorshipMinisterio de Economía y Competitividad (MINECO)/ ISC-III
dc.description.sponsorshipUCM-BSCH
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/46805
dc.identifier.doi10.3389/fnbeh.2017.00233
dc.identifier.issn1662-5153
dc.identifier.officialurlhttps://www.frontiersin.org/journals/behavioral-neuroscience
dc.identifier.urihttps://hdl.handle.net/20.500.14352/18450
dc.journal.titleFrontiers in Behavioral Neuroscience
dc.language.isoeng
dc.publisherFrontiers Media
dc.relation.projectIDRETICS program Red de Trastornos Adictivos (programs RD12/0028 and RD16/0017); grants: RD2012/0028/0021, RD12/0028/0007, RD16/0017/0008 and RD16/0017/0001
dc.relation.projectID(PI16/01689)
dc.relation.projectIDUCM (951579)
dc.rightsAtribución 3.0 España
dc.rights.accessRightsopen access
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/es/
dc.subject.cdu591.1
dc.subject.cdu599.32
dc.subject.keywordalcohol
dc.subject.keywordadolescence
dc.subject.keyworddrinking-in-the-dark
dc.subject.keywordsex differences
dc.subject.keywordcognitive function
dc.subject.keywordneural plasticity
dc.subject.keywordhippocampal formation
dc.subject.keywordfrontal cortex
dc.subject.ucmBiología
dc.subject.ucmFisiología animal (Biología)
dc.subject.ucmMamíferos
dc.subject.unesco24 Ciencias de la Vida
dc.subject.unesco2401.13 Fisiología Animal
dc.subject.unesco2401.18 Mamíferos
dc.titleLong-term effects of intermittent adolescent alcohol exposure in male and female rats
dc.typejournal article
dc.volume.number11
dspace.entity.typePublication
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