S-nitrosylation: a potential new paradigm in signal transduction

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dc.contributor.authorMartínez Ruiz, Antonio
dc.contributor.authorLamas, Santiago
dc.date.accessioned2024-04-04T11:20:35Z
dc.date.available2024-04-04T11:20:35Z
dc.date.issued2004-04-01
dc.description.abstractMuch attention has been paid to nitric oxide (NO) research since its discovery as a physiological mediator in the cardiovascular system. In recent years, newer roles have been attributed to this molecule and its close relatives, termed collectively reactive nitrogen species (RNS). These roles relate to different mechanisms of protein modification, among which S-nitrosylation of cysteines has emerged as a potential new paradigm in signal transduction and regulation of protein function. We review here the chemical basis of this modification compared with other protein modifications related to nitric oxide, as well as the kind of specificity we can expect from it. We also review the current methodologies that can be applied to the study of S-nitrosylation and identification of S-nitrosylated proteins in cells, and detail the relevance of this modification in several proteins related to cardiovascular system.
dc.description.departmentDepto. de Bioquímica y Biología Molecular
dc.description.facultyFac. de Farmacia
dc.description.refereedTRUE
dc.description.sponsorshipPlan Nacional de I + D + I, Ministerio de Ciencia y Tecnología
dc.description.sponsorshipComunidad Autónoma de Madrid (08.4/0030.1/2003)
dc.description.sponsorshipMinisterio de Sanidad (RECAVA network)
dc.description.statuspub
dc.identifier.doi10.1016/j.cardiores.2004.01.013
dc.identifier.issn0008-6363
dc.identifier.urihttps://hdl.handle.net/20.500.14352/102710
dc.issue.number62
dc.journal.titleCardiovascular Research
dc.language.isoeng
dc.page.final52
dc.page.initial43
dc.relation.projectIDSAF 2000-0149
dc.relation.projectIDSAF 2003-01039
dc.rights.accessRightsopen access
dc.subject.cdu577.1
dc.subject.cdu577.2
dc.subject.keywordSignal transduction
dc.subject.keywordNitric oxide
dc.subject.ucmBioquímica (Farmacia)
dc.subject.unesco2302 Bioquímica
dc.titleS-nitrosylation: a potential new paradigm in signal transduction
dc.typejournal article
dc.type.hasVersionAM
dspace.entity.typePublication
relation.isAuthorOfPublicationeec0b303-34c9-47dd-9ec6-704b6c6c7acd
relation.isAuthorOfPublication.latestForDiscoveryeec0b303-34c9-47dd-9ec6-704b6c6c7acd
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