A versatile fluorescent molecular probe endowed with singlet oxygen generation under white-light photosensitization

Simple item page
dc.contributor.authorDurán Sampedro, Gonzalo
dc.contributor.authorEpelde Elezcano, Nerea
dc.contributor.authorMartínez Martínez, Virginia
dc.contributor.authorEsnal Martínez, Ixone
dc.contributor.authorBañuelos Prieto, Jorge
dc.contributor.authorGarcía Moreno, Inmaculada
dc.contributor.authorRodríguez Agarrabeitia, Antonia
dc.contributor.authorMoya Cerero, Santiago De La
dc.contributor.authorTabero Truchado, Andrea
dc.contributor.authorLázaro Carrillo, Ana
dc.contributor.authorVillanueva Oroquieta, Ángeles
dc.contributor.authorOrtiz García, María Josefa
dc.contributor.authorLópez Arbeloa, Íñigo María
dc.date.accessioned2023-06-17T22:09:39Z
dc.date.available2023-06-17T22:09:39Z
dc.date.issued2017-07-01
dc.descriptionReceived 30 January 2017, Revised 10 March 2017, Accepted 11 March 2017, Available online 12 March 2017.
dc.description.abstractDespite fluorescent photodynamic therapy (fluorescent-PDT) dyes are promising theranostic agents, current approaches unfortunately involve crucial shortcomings (such as, narrow absorption bands, high cost, low bio-compatibility and specificity, low dual efficiency) making difficult their clinical translation. Particularly, efficient fluorescent-PDT agents triggered under white-light, with potential application in topic solar treatments, are scarce. Here, we describe the rational development of a novel fluorescent-PDT molecular biomaterial based on BODIPY building blocks able to sustain, simultaneously, synthetic accessibility, high fluorescence and phototoxicity within a broad spectral window, biocompatibility, including low dark toxicity and high cell permeability with selective accumulation in lysosomes and, what is more important, excellent efficient activity triggered under white light. These all-in-one combined properties make the new dye a valuable ground platform for the development of future smarter theranostic agents.
dc.description.departmentSección Deptal. de Química Orgánica (Óptica y Optometría)
dc.description.facultyFac. de Óptica y Optometría
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Economía y Competitividad (MINECO)
dc.description.sponsorshipComunidad de Madrid
dc.description.sponsorshipGobierno Vasco
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/45025
dc.identifier.doi10.1016/j.dyepig.2017.03.026
dc.identifier.issn0143-7208
dc.identifier.officialurlhttp://dx.doi.org/10.1016/j.dyepig.2017.03.026
dc.identifier.urihttps://hdl.handle.net/20.500.14352/18152
dc.journal.titleDyes and Pigments
dc.language.isoeng
dc.page.final87
dc.page.initial77
dc.publisherElsevier
dc.relation.projectIDCTQ2013-48767-C3-3-R
dc.relation.projectIDMAT2014-51937-C3-1-P
dc.relation.projectIDMAT2014-51937-C3-2-P
dc.relation.projectIDMAT2014-51937-C3-3-P
dc.relation.projectIDMAT2015-68837-REDT
dc.relation.projectIDNANOFRONTMAG-CM (S2013/MIT-2850)
dc.relation.projectIDIT912-16
dc.relation.projectIDRYC-2011-09505
dc.rights.accessRightsrestricted access
dc.subject.cdu543.426
dc.subject.cdu547.1
dc.subject.cdu535.37:61-07
dc.subject.keywordBODIPY dyes
dc.subject.keywordPhotosensitizers
dc.subject.keywordSinglet oxygen
dc.subject.keywordTheragnosis
dc.subject.keywordWhite light
dc.subject.keywordPhotodynamic therapy
dc.subject.ucmFísica (Química)
dc.subject.ucmMateriales
dc.subject.ucmQuímica orgánica (Química)
dc.subject.ucmBioquímica (Biología)
dc.subject.unesco3312 Tecnología de Materiales
dc.subject.unesco2306 Química Orgánica
dc.subject.unesco2302 Bioquímica
dc.titleA versatile fluorescent molecular probe endowed with singlet oxygen generation under white-light photosensitization
dc.typejournal article
dc.volume.number142
dspace.entity.typePublication
relation.isAuthorOfPublication0486160c-3df6-4270-bf91-3e96cd33d85d
relation.isAuthorOfPublication7940c6e8-25c3-4083-b533-0c34e155dfa8
relation.isAuthorOfPublication07f337af-8a30-4929-81db-4e92176e5c87
relation.isAuthorOfPublication.latestForDiscovery0486160c-3df6-4270-bf91-3e96cd33d85d
Download
Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Agarrabeitia_versatile florescent-Elsevier-2017.pdf
Size:
1.23 MB
Format:
Adobe Portable Document Format
Download
Collections
Artículos