Electrophysiological monitoring of hearing function during cochlear perilymphatic perfusions

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dc.contributor.authorSan Román, Jesus
dc.contributor.authorCarricondo Orejana, Francisco Javier
dc.contributor.authorIglesias Moreno, María Cruz
dc.contributor.authorMartín-Villares, Cristina
dc.contributor.authorPoch Broto, Joaquín
dc.contributor.authorGil Loyzaga, Pablo
dc.date.accessioned2024-01-17T08:12:09Z
dc.date.available2024-01-17T08:12:09Z
dc.date.issued2012-09-01
dc.description.abstractConclusion: The cochlear perilymphatic perfusion produces, by itself, significant effects in the cochlear physiology that could be associated with the surgical procedure. These effects need to be well characterized to allow a reliable quantification of the effects of the experimental agent being tested. Objectives: The study focused on the accurate description of the electrophysiological effects on the cochlear potential recordings of perilymphatic perfusions. Methods: Two successive cochlear perilymphatic perfusions were carried out. The first used artificial perilymph. The second used artificial perilymph alone or a kainic acid (KA) solution in artificial perilymph. The compound action potential of the auditory nerve (CAP-AN) was recorded: (1) before the first perfusion, (2) after the first perfusion and (3) after the second perfusion, and compared between groups. Results: The first intracochlear perfusion with artificial perilymph produced significant effects in the CAP-AN that could be related to the surgical procedure. These effects were analysed separately from the effects produced by the KA. In particular, the KA administered intracochlearly produced a significant increase in the latency and a decrease in the amplitude of the CAP-AN N1 wave compared with the controls that were perfused twice with artificial perilymph.
dc.description.departmentDepto. de Inmunología, Oftalmología y ORL
dc.description.facultyFac. de Medicina
dc.description.refereedTRUE
dc.description.sponsorshipUniversidad Complutense de Madrid
dc.description.statuspub
dc.identifier.citationSan Román, J., Carricondo, F., Iglesias-Moreno, M. C., Martín-Villares, C., Poch-Broto, J., & Gil-Loyzaga, P. (2012). Electrophysiological monitoring of hearing function during cochlear perilymphatic perfusions. Acta oto-laryngologica, 132(9), 916–922. https://doi.org/10.3109/00016489.2012.678945
dc.identifier.doi10.3109/00016489.2012.678945
dc.identifier.essn1651-2251
dc.identifier.issn0001-6489
dc.identifier.officialurlhttps://www.tandfonline.com/doi/full/10.3109/00016489.2012.678945
dc.identifier.pmid22667457
dc.identifier.relatedurlhttps://www.tandfonline.com/journals/ioto20
dc.identifier.urihttps://hdl.handle.net/20.500.14352/93504
dc.issue.number9
dc.journal.titleActa oto-laryngologica
dc.language.isoeng
dc.page.final922
dc.page.initial916
dc.publisherTaylor & Francis
dc.rights.accessRightsopen access
dc.subject.cdu616.21
dc.subject.keywordHypoacusia
dc.subject.keywordexcitotoxic amino acids
dc.subject.keywordrat
dc.subject.keywordkainic acid
dc.subject.keywordcochlear decompression
dc.subject.keywordcochlear evoked potentials
dc.subject.keywordcompound action potential of the auditory nerve
dc.subject.keywordelectrocochleography
dc.subject.keywordartificial perilymph
dc.subject.ucmNeurociencias (Biológicas)
dc.subject.ucmFisiología
dc.subject.ucmOtorrinolaringología
dc.subject.unesco2411.13 Fisiología de la Audición
dc.titleElectrophysiological monitoring of hearing function during cochlear perilymphatic perfusions
dc.typejournal article
dc.type.hasVersionCVoR
dc.volume.number132
dspace.entity.typePublication
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relation.isAuthorOfPublication808309c2-41d5-4ed0-a5e1-06568017dee1
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relation.isAuthorOfPublication.latestForDiscoveryaf3cf786-2b1f-460c-a0c6-d14571344a66
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