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First Insights into the Biological Activity and Molecular Docking of Citral (3,7-Dimethyl-2,6-Octadienal) Against Trichomonas vaginalis.

dc.contributor.authorIbáñez Escribano, Alexandra
dc.contributor.authorMello, A.B.
dc.contributor.authorFenalti, J.M.
dc.contributor.authorBaccega, B
dc.contributor.authorWahast Islabão, Y.
dc.contributor.authorMartins, F. O.
dc.contributor.authorBirmann, P. T.
dc.contributor.authorCasaril, A. M.
dc.contributor.authorBarbosa, T. N.
dc.contributor.authorSena-Lopes, A.
dc.contributor.authorMonteiro, F. L.
dc.contributor.authorSavegnago, L.
dc.contributor.authorBorsuk, S.
dc.contributor.authorHubner, S. d. O.
dc.contributor.authorFarias, N. d. A. d. R
dc.contributor.authorIbáñez-Escribano, Alexandra
dc.contributor.authorOliveira, C. B.
dc.date.accessioned2025-07-07T08:50:21Z
dc.date.available2025-07-07T08:50:21Z
dc.date.issued2025
dc.description.abstractThe increasing resistance of Trichomonas vaginalis to the only approved chemical family of drugs for treatment, the 5-nitroimidazoles, has prompted the exploration of new therapeutic agents against this prevalent non-viral sexually transmitted infection. Natural products have emerged as a significant source of novel treatments for trichomoniasis. The aim of this study was to evaluate the anti-T. vaginalis activity of citral (3,7-dimethyl-2,6-octadienal), the main constituent of the essential oil of Cymbopogon species, commonly known as lemongrass. Our findings indicate that citral exhibits a minimum inhibitory concentration (MIC) of 100 μM, effectively inhibiting the growth of T. vaginalis trophozoites within 12 h of exposure, and a 50% inhibitory concentration (IC50) of approximately 40 μM after 24 h. Furthermore, the evaluation of nitric oxide (NO) levels suggests that citral possesses antioxidant properties. Molecular docking studies reveal a weak interaction with three parasite proteins: thioredoxin reductase (TvTrxR), purine nucleoside phosphorylase (TvPNP), and methionine gamma lyase (TvMGL). The present study highlights the potential of citral as a candidate for the development of no-nitroimidazole drugs, offering new avenues for trichomoniasis treatment and underscoring the importance of further investigation into citral’s mechanism of action.
dc.description.departmentDepto. de Microbiología y Parasitología
dc.description.facultyFac. de Farmacia
dc.description.refereedTRUE
dc.description.sponsorshipApoio a Pós-Graduação (PROAP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.statuspub
dc.identifier.citationMello, A.B.d.; Fenalti, J.M.; Baccega, B.; Wahast Islabão, Y.; Martins, F.O.; Birmann, P.T.; Casaril, A.M.; Barbosa, T.N.; Sena-Lopes, A.; Monteiro, F.L.; et al. First Insights into the Biological Activity and Molecular Docking of Citral (3,7-Dimethyl-2, 6-Octadienal) Against Trichomonas vaginalis. Microbiol. Res. 2025, 16, 96. https://doi.org/10.3390/ microbiolres16050096
dc.identifier.doi10.3390/microbiolres16050096
dc.identifier.officialurlhttps://doi.org/10.3390/microbiolres16050096
dc.identifier.relatedurlhttps://www.mdpi.com/2036-7481/16/5/96
dc.identifier.urihttps://hdl.handle.net/20.500.14352/122254
dc.issue.number96
dc.journal.titleMicrobiology Research
dc.language.isoeng
dc.publisherMDPI
dc.rightsAttribution 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.cdu579.66
dc.subject.cdu615.28
dc.subject.cdu615.9
dc.subject.keywordnatural products
dc.subject.keywordsexually transmitted infection
dc.subject.keywordtrichomoniasis
dc.subject.keywordnitric oxide
dc.subject.keywordlemongrass
dc.subject.ucmMicrobiología (Farmacia)
dc.subject.ucmToxicología (Farmacia)
dc.subject.ucmMedicamentos
dc.subject.unesco3207.12 Parasitología
dc.titleFirst Insights into the Biological Activity and Molecular Docking of Citral (3,7-Dimethyl-2,6-Octadienal) Against Trichomonas vaginalis.
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number16
dspace.entity.typePublication
relation.isAuthorOfPublication19cf7832-35c7-4fa9-b031-7a951d151623
relation.isAuthorOfPublication.latestForDiscovery19cf7832-35c7-4fa9-b031-7a951d151623

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