First Insights into the Biological Activity and Molecular Docking of Citral (3,7-Dimethyl-2,6-Octadienal) Against Trichomonas vaginalis.
dc.contributor.author | Ibáñez Escribano, Alexandra | |
dc.contributor.author | Mello, A.B. | |
dc.contributor.author | Fenalti, J.M. | |
dc.contributor.author | Baccega, B | |
dc.contributor.author | Wahast Islabão, Y. | |
dc.contributor.author | Martins, F. O. | |
dc.contributor.author | Birmann, P. T. | |
dc.contributor.author | Casaril, A. M. | |
dc.contributor.author | Barbosa, T. N. | |
dc.contributor.author | Sena-Lopes, A. | |
dc.contributor.author | Monteiro, F. L. | |
dc.contributor.author | Savegnago, L. | |
dc.contributor.author | Borsuk, S. | |
dc.contributor.author | Hubner, S. d. O. | |
dc.contributor.author | Farias, N. d. A. d. R | |
dc.contributor.author | Ibáñez-Escribano, Alexandra | |
dc.contributor.author | Oliveira, C. B. | |
dc.date.accessioned | 2025-07-07T08:50:21Z | |
dc.date.available | 2025-07-07T08:50:21Z | |
dc.date.issued | 2025 | |
dc.description.abstract | The increasing resistance of Trichomonas vaginalis to the only approved chemical family of drugs for treatment, the 5-nitroimidazoles, has prompted the exploration of new therapeutic agents against this prevalent non-viral sexually transmitted infection. Natural products have emerged as a significant source of novel treatments for trichomoniasis. The aim of this study was to evaluate the anti-T. vaginalis activity of citral (3,7-dimethyl-2,6-octadienal), the main constituent of the essential oil of Cymbopogon species, commonly known as lemongrass. Our findings indicate that citral exhibits a minimum inhibitory concentration (MIC) of 100 μM, effectively inhibiting the growth of T. vaginalis trophozoites within 12 h of exposure, and a 50% inhibitory concentration (IC50) of approximately 40 μM after 24 h. Furthermore, the evaluation of nitric oxide (NO) levels suggests that citral possesses antioxidant properties. Molecular docking studies reveal a weak interaction with three parasite proteins: thioredoxin reductase (TvTrxR), purine nucleoside phosphorylase (TvPNP), and methionine gamma lyase (TvMGL). The present study highlights the potential of citral as a candidate for the development of no-nitroimidazole drugs, offering new avenues for trichomoniasis treatment and underscoring the importance of further investigation into citral’s mechanism of action. | |
dc.description.department | Depto. de Microbiología y Parasitología | |
dc.description.faculty | Fac. de Farmacia | |
dc.description.refereed | TRUE | |
dc.description.sponsorship | Apoio a Pós-Graduação (PROAP) | |
dc.description.sponsorship | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | |
dc.description.status | pub | |
dc.identifier.citation | Mello, A.B.d.; Fenalti, J.M.; Baccega, B.; Wahast Islabão, Y.; Martins, F.O.; Birmann, P.T.; Casaril, A.M.; Barbosa, T.N.; Sena-Lopes, A.; Monteiro, F.L.; et al. First Insights into the Biological Activity and Molecular Docking of Citral (3,7-Dimethyl-2, 6-Octadienal) Against Trichomonas vaginalis. Microbiol. Res. 2025, 16, 96. https://doi.org/10.3390/ microbiolres16050096 | |
dc.identifier.doi | 10.3390/microbiolres16050096 | |
dc.identifier.officialurl | https://doi.org/10.3390/microbiolres16050096 | |
dc.identifier.relatedurl | https://www.mdpi.com/2036-7481/16/5/96 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14352/122254 | |
dc.issue.number | 96 | |
dc.journal.title | Microbiology Research | |
dc.language.iso | eng | |
dc.publisher | MDPI | |
dc.rights | Attribution 4.0 International | en |
dc.rights.accessRights | open access | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject.cdu | 579.66 | |
dc.subject.cdu | 615.28 | |
dc.subject.cdu | 615.9 | |
dc.subject.keyword | natural products | |
dc.subject.keyword | sexually transmitted infection | |
dc.subject.keyword | trichomoniasis | |
dc.subject.keyword | nitric oxide | |
dc.subject.keyword | lemongrass | |
dc.subject.ucm | Microbiología (Farmacia) | |
dc.subject.ucm | Toxicología (Farmacia) | |
dc.subject.ucm | Medicamentos | |
dc.subject.unesco | 3207.12 Parasitología | |
dc.title | First Insights into the Biological Activity and Molecular Docking of Citral (3,7-Dimethyl-2,6-Octadienal) Against Trichomonas vaginalis. | |
dc.type | journal article | |
dc.type.hasVersion | VoR | |
dc.volume.number | 16 | |
dspace.entity.type | Publication | |
relation.isAuthorOfPublication | 19cf7832-35c7-4fa9-b031-7a951d151623 | |
relation.isAuthorOfPublication.latestForDiscovery | 19cf7832-35c7-4fa9-b031-7a951d151623 |
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