Diamine oxidase levels in different chronic urticaria phenotypes

Simple item page
dc.contributor.authorAlvaro Daschner
dc.contributor.authorJuan González-Fernández
dc.contributor.authorAna Valls
dc.contributor.authorConsolación de Frutos
dc.contributor.authorMarta Rodero
dc.contributor.authorGonzález Fernández, Juan
dc.contributor.authorCuéllar Del Hoyo, María Del Carmen
dc.contributor.authorRodero Martínez, Marta
dc.date.accessioned2024-01-19T12:14:54Z
dc.date.available2024-01-19T12:14:54Z
dc.date.issued2015-11
dc.description.abstractBackground: Diamine oxidase (DAO) is a polyamine-degrading enzyme also implicated in histamine metabolism. Chronic urticaria (CU) has a wide spectrum of clinical presentations and causes. Anisakis sensitisation associated chronic urticaria (CU+) has been characterised as a phenotype with different clinical and immunological characteristics and possibly associated with previous acute parasitism. We aimed to analyse serum DAO levels in different CU phenotypes. We further analysed the possible association of DAO with fish eating habits. Methods: We studied 35 CU+ patients and 39 non-sensitised CU patients (CU-) as well as 19 controls. We analysed fish-eating frequency as well as fish intake associated exacerbation of CU (FIAE) or gastro-intestinal complaints (GI). DAO levels were further analysed with respect to lymphoproliferative responses, cytokine and specific IgE production. Results: DAO levels were not different between CU and controls, but were significantly higher in CU+ than in CU-. CU+ patients with FIAE had lower DAO levels, but no differences were detected in patients with GI. DAO levels correlated positively with oily and canned fish consumption in CU-. In CU+, DAO levels correlated positively with specific Anisakis IgE, percentages of proliferation in Anisakis stimulated peripheral blood lymphocytes, serum IL-2 and IL-6, but correlated negatively with mitogen stimulated TGF-β in supernatants. Conclusions: DAO levels in CU depend on fish-eating habits and in CU+ on the amount of specific IgE production. In the CU+ phenotype, lower levels of DAO predispose to urticaria exacerbation after fish intake, probably due to a relative insufficient enteric availability of this enzyme.
dc.description.departmentDepto. de Microbiología y Parasitología
dc.description.facultyFac. de Farmacia
dc.description.refereedTRUE
dc.description.sponsorshipFundación Sociedad Española de Alergología e Inmunología Clínica
dc.description.sponsorshipFundación Mutua Madrileña
dc.description.statuspub
dc.identifier.citationDaschner A, González-Fernández J, Valls A, de Frutos C, Rodero M, Cuéllar C. Diamine oxidase levels in different chronic urticaria phenotypes. Allergol Immunopathol (Madr). 2015 Nov-Dec;43(6):593-600.
dc.identifier.doi10.1016/j.aller.2015.01.009
dc.identifier.issn0301-0546
dc.identifier.officialurlhttps://doi.org/10.1016/j.aller.2015.01.009
dc.identifier.urihttps://hdl.handle.net/20.500.14352/94042
dc.issue.number6
dc.journal.titleAllergologia et Immunopathologia
dc.language.isoeng
dc.page.final600
dc.page.initial593
dc.publisherElsevier
dc.rights.accessRightsrestricted access
dc.subject.keywordAnisakis
dc.subject.keywordChronic urticaria
dc.subject.keywordCytokines
dc.subject.keywordDiamine oxidase
dc.subject.keywordDiet
dc.subject.ucmParasitología (Farmacia)
dc.subject.unesco3207.12 Parasitología
dc.titleDiamine oxidase levels in different chronic urticaria phenotypes
dc.typejournal article
dc.volume.number43
dspace.entity.typePublication
relation.isAuthorOfPublicationfb07d421-e0c9-4722-83bd-4be5e3901c6d
relation.isAuthorOfPublication6c555fb4-e29c-4463-8062-a9699fcebaa6
relation.isAuthorOfPublication5b09d749-d306-40df-b523-4ab0a479f162
relation.isAuthorOfPublication.latestForDiscoveryfb07d421-e0c9-4722-83bd-4be5e3901c6d
Download
Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
S030105461500052X.pdf
Size:
635.57 KB
Format:
Adobe Portable Document Format
Download
Collections
Artículos