Publication:
Stochastic descriptors to study the fate and potential of naive T cell clonotypes in the periphery

dc.contributor.authorArtalejo, Jesús R.
dc.contributor.authorGómez-Corral, Antonio
dc.contributor.authorLópez-García, M.
dc.contributor.authorMolina París, C.
dc.date.accessioned2023-06-18T06:55:41Z
dc.date.available2023-06-18T06:55:41Z
dc.date.issued2016
dc.description.abstractThe population of naive T cells in the periphery is best described by determining both its T cell receptor diversity, or number of clonotypes, and the sizes of its clonal subsets. In this paper, we make use of a previously introduced mathematical model of naive T cell homeostasis, to study the fate and potential of naive T cell clonotypes in the periphery. This is achieved by the introduction of several new stochastic descriptors for a given naive T cell clonotype, such as its maximum clonal size, the time to reach this maximum, the number of proliferation events required to reach this maximum, the rate of contraction of the clonotype during its way to extinction, as well as the time to a given number of proliferation events. Our results show that two fates can be identified for the dynamics of the clonotype: extinction in the short-term if the clonotype experiences too hostile a peripheral environment, or establishment in the periphery in the long-term. In this second case the probability mass function for the maximum clonal size is bimodal, with one mode near one and the other mode far away from it. Our model also indicates that the fate of a recent thymic emigrant (RTE) during its journey in the periphery has a clear stochastic component, where the probability of extinction cannot be neglected, even in a friendly but competitive environment. On the other hand, a greater deterministic behaviour can be expected in the potential size of the clonotype seeded by the RTE in the long-term, once it escapes extinction.
dc.description.departmentDepto. de Estadística e Investigación Operativa
dc.description.facultyFac. de Ciencias Matemáticas
dc.description.refereedTRUE
dc.description.sponsorshipUnión Europea. FP7
dc.description.sponsorshipMinisterio de Economía y Competitividad (MINECO)
dc.description.sponsorshipthe Leverhulme Trust, Research
dc.description.sponsorshipBBSRC
dc.description.sponsorshipSevero Ochoa Excellence Program
dc.description.statusinpress
dc.eprint.idhttps://eprints.ucm.es/id/eprint/39064
dc.identifier.doi10.1007/s00285-016-1020-6
dc.identifier.issn0303-6812
dc.identifier.officialurlhttp://bit.ly/2cHm0eW
dc.identifier.urihttps://hdl.handle.net/20.500.14352/24603
dc.journal.titleJournal of Mathematical Biology
dc.language.isoeng
dc.page.final36
dc.page.initial1
dc.publisherSpringer
dc.relation.projectIDQuanTI (317040)
dc.relation.projectIDProject MTM-2011-23864
dc.relation.projectIDProject FIS2009-12964-C05-03
dc.relation.projectIDProject FIS2013-47949-C2-2-P
dc.relation.projectIDRPG-2012-772
dc.relation.projectIDBB/G023395/1
dc.relation.projectIDSEV-2015-0554
dc.rightsAtribución 3.0 España
dc.rights.accessRightsopen access
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/es/
dc.subject.cdu519.216
dc.subject.keywordCompetition
dc.subject.keywordCross-reactivity
dc.subject.keywordExtinction
dc.subject.keywordStochastic descriptor
dc.subject.keywordStochastic univariate birth and death process
dc.subject.keywordT cell homeostasis
dc.subject.keywordTCR diversity.
dc.subject.ucmProcesos estocásticos
dc.subject.unesco1208.08 Procesos Estocásticos
dc.titleStochastic descriptors to study the fate and potential of naive T cell clonotypes in the periphery
dc.typejournal article
dspace.entity.typePublication
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