Targeting the Gut Microbiota of Vertically HIV-Infected Children to Decrease Inflammation and Immunoactivation: A Pilot Clinical Trial

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dc.contributor.authorSainz, Talía
dc.contributor.authorDiaz, Laura
dc.contributor.authorRojo, David
dc.contributor.authorClemente, María Isabel
dc.contributor.authorBarbas, Coral
dc.contributor.authorGosalbes, María José
dc.contributor.authorJiménez Hernández, Nuria
dc.contributor.authorEscosa, Luis
dc.contributor.authorGuillen, Sara
dc.contributor.authorRamos Amador, José Tomás
dc.contributor.authorMuñoz Fernández, María Ángeles
dc.contributor.authorNavarro, María Luisa
dc.contributor.authorMellado, María José
dc.contributor.authorSerrano Villar, Sergio
dc.date.accessioned2023-06-22T10:49:25Z
dc.date.available2023-06-22T10:49:25Z
dc.date.issued2022-02-23
dc.description.abstractAims: Children with HIV exhibit chronic inflammation and immune dysfunction despite antiretroviral therapy (ART). Strategies targeting persistent inflammation are needed to improve health in people living with HIV. The gut microbiota likely interacts with the immune system, but the clinical implications of modulating the dysbiosis by nutritional supplementation are unclear. Methods: Pilot, double-blind, randomized placebo-controlled trial in which 24 HIV-infected on ART were randomized to supplementation with a daily mixture of symbiotics, omega-3/6 fatty acids and amino acids, or placebo four weeks, in combination with ART. We analyzed inflammatory markers and T-cell activation changes and their correlations with shifts in fecal microbiota. Results: Twenty-four HIV-infected children were recruited and randomized to receive a symbiotic nutritional supplement or placebo. Mean age was 12 ± 3.9 years, 62.5% were female. All were on ART and had HIV RNA < 50/mL. We did not detect changes in inflammatory (IL-6, IL-7, IP-10), microbial translocation (sCD14), mucosal integrity markers (IFABP, zonulin) or the kynurenine to tryptophan ratio, or changes in markers of the adaptive immune response in relation to the intervention. However, we found correlations between several key bacteria and the assessed inflammatory and immunological parameters, supporting a role of the microbiota in immune modulation in children with HIV. Conclusions: In this exploratory study, a four-week nutritional supplementation had no significant effects in terms of decreasing inflammation, microbial translocation, or T-cell activation in HIV-infected children. However, the correlations found support the interaction between gut microbiota and the immune system.
dc.description.departmentDepto. de Medicina
dc.description.departmentDepto. de Salud Pública y Materno - Infantil
dc.description.facultyFac. de Medicina
dc.description.refereedTRUE
dc.description.sponsorshipInstituto de Salud Carlos III (ISCIII)/ FEDER
dc.description.sponsorshipInstituto de Salud Carlos III
dc.description.sponsorshipSpanish Society of Microbiology and Infectious Diseases (SEIMC)/Spanish Ministry of Science and Innovation/Instituto de Salud Carlos III/FEDER
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/73359
dc.identifier.doi10.3390/nu14050992
dc.identifier.issn2072-6643
dc.identifier.officialurlhttps://doi.org/10.3390/nu14050992
dc.identifier.relatedurlhttps://www.mdpi.com/2072-6643/14/5/992/htm
dc.identifier.urihttps://hdl.handle.net/20.500.14352/71731
dc.issue.number5
dc.journal.titleNutrients
dc.language.isoeng
dc.page.initial992
dc.publisherMPDI
dc.relation.projectID(PI13/0422, PI17/01283, AC17/00019, PI18/00154, ICI20/00058)
dc.relation.projectID(RD06/0006/0034 and RD06/0006/0035)
dc.relation.projectID(Contratos Juan Rodés R16/00021 and BAE BA21/00022) (BA21/00017)
dc.rightsAtribución 3.0 España
dc.rights.accessRightsopen access
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/es/
dc.subject.keywordHIV
dc.subject.keywordinflammation
dc.subject.keywordimmunoactivation
dc.subject.keywordmicrobiota
dc.subject.keywordchildren
dc.subject.ucmGastroenterología y hepatología
dc.subject.unesco3205.03 Gastroenterología
dc.titleTargeting the Gut Microbiota of Vertically HIV-Infected Children to Decrease Inflammation and Immunoactivation: A Pilot Clinical Trial
dc.typejournal article
dc.volume.number14
dspace.entity.typePublication
relation.isAuthorOfPublicationaa73d86f-18aa-422f-ba37-7e97e4efde5b
relation.isAuthorOfPublication.latestForDiscoveryaa73d86f-18aa-422f-ba37-7e97e4efde5b
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