Oxidative stress, the blood–brain barrier and neurodegenerative diseases: The critical beneficial role of dietary antioxidants

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dc.contributor.authorFeng, Jin
dc.contributor.authorZheng, Youle
dc.contributor.authorGuo, Mingyue
dc.contributor.authorAres Lombán, Irma
dc.contributor.authorMartínez Caballero, Marta
dc.contributor.authorLópez Torres, Bernardo
dc.contributor.authorMartínez Larrañaga, María Rosa
dc.contributor.authorWang, Xu
dc.contributor.authorAnadón Navarro, Arturo Ramón
dc.contributor.authorMartínez Caballero, María Aranzazu
dc.date.accessioned2024-05-22T13:31:47Z
dc.date.available2024-05-22T13:31:47Z
dc.date.issued2023-10
dc.description2023 Acuerdos Transformativos CRUE
dc.description.abstractIn recent years, growing awareness of the role of oxidative stress in brain health has prompted antioxidants, especially dietary antioxidants, to receive growing attention as possible treatments strategies for patients with neurodegenerative diseases (NDs). The most widely studied dietary antioxidants include active substances such as vitamins, carotenoids, flavonoids and polyphenols. Dietary antioxidants are found in usually consumed foods such as fresh fruits, vegetables, nuts and oils and are gaining popularity due to recently growing awareness of their potential for preventive and protective agents against NDs, as well as their abundant natural sources, generally non-toxic nature, and ease of long-term consumption. This review article examines the role of oxidative stress in the development of NDs, explores the ‘two-sidedness’ of the blood–brain barrier (BBB) as a protective barrier to the nervous system and an impeding barrier to the use of antioxidants as drug medicinal products and/or dietary antioxidants supplements for prevention and therapy and reviews the BBB permeability of common dietary antioxidant suplements and their potential efficacy in the prevention and treatment of NDs. Finally, current challenges and future directions for the prevention and treatment of NDs using dietary antioxidants are discussed, and useful information on the prevention and treatment of NDs is provided.
dc.description.departmentSección Deptal. de Farmacología y Toxicología (Veterinaria)
dc.description.facultyFac. de Veterinaria
dc.description.fundingtypeAPC financiada por la UCM
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Ciencia e Innovación (España)
dc.description.statuspub
dc.identifier.citationJin Feng, Youle Zheng, Mingyue Guo, Irma Ares, Marta Martínez, Bernardo Lopez-Torres, María-Rosa Martínez-Larrañaga, Xu Wang, Arturo Anadón, María-Aránzazu Martínez, Oxidative stress, the blood–brain barrier and neurodegenerative diseases: The critical beneficial role of dietary antioxidants, Acta Pharmaceutica Sinica B, Volume 13, Issue 10, 2023, Pages 3988-4024, https://doi.org/10.1016/j.apsb.2023.07.010.
dc.identifier.doi10.1016/j.apsb.2023.07.010
dc.identifier.essn2211-3835
dc.identifier.officialurlhttps://doi.org/10.1016/j.apsb.2023.07.010
dc.identifier.pmid37799389
dc.identifier.urihttps://hdl.handle.net/20.500.14352/104322
dc.issue.number10
dc.journal.titleActa Pharmaceutica Sinica B
dc.language.isoeng
dc.page.final4024
dc.page.initial3988
dc.publisherChinese Pharmaceutical Association
dc.relation.projectIDPID 2020-115979RR-C33
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.cdu615.1
dc.subject.keywordDietary antioxidant supplements
dc.subject.keywordOxidative stress
dc.subject.keywordBlood–brain barrier
dc.subject.keywordNeurodegenerative diseases
dc.subject.keywordVitamins
dc.subject.keywordCarotenoids
dc.subject.keywordFlavonoids
dc.subject.keywordPolyphenols
dc.subject.ucmFarmacología (Farmacia)
dc.subject.unesco3109.08 Farmacología
dc.titleOxidative stress, the blood–brain barrier and neurodegenerative diseases: The critical beneficial role of dietary antioxidants
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number13
dspace.entity.typePublication
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