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Klumpfuss controls FMRFamide expression by enabling BMP signaling within the NB5-6 lineage

dc.contributor.authorLosada Pérez, María De La Paloma
dc.contributor.authorGabilondo, Hugo
dc.contributor.authorMolina, Isabel
dc.contributor.authorTuriegano, Enrique
dc.contributor.authorTorroja, Laura
dc.contributor.authorThor, Stefan
dc.contributor.authorBenito-Sipos, Jonathan
dc.date.accessioned2024-01-23T14:10:49Z
dc.date.available2024-01-23T14:10:49Z
dc.date.issued2013
dc.descriptionThis work was supported by a grant from the Spanish Ministerio de Ciencia e Innovación [BFU-2008-04683-C02-02] to L.T.; and by the Swedish Research Council, the Swedish Strategic Research Foundation, the Knut and Alice Wallenberg Foundation, the Swedish Brain Foundation, the Swedish Cancer Foundation and the Swedish Royal Academy of Sciences to S.T.
dc.description.abstractA number of transcription factors that are expressed within most, if not all, embryonic neuroblast (NB) lineages participate in neural subtype specification. Some have been extensively studied in several NB lineages (e.g. components of the temporal gene cascade) whereas others only within specific NB lineages. To what extent they function in other lineages remains unknown. Klumpfuss (Klu), the Drosophila ortholog of the mammalian Wilms tumor 1 (WT1) protein, is one such transcription factor. Studies in the NB4-2 lineage have suggested that Klu functions to ensure that the two ganglion mother cells (GMCs) in this embryonic NB lineage acquire different fates. Owing to limited lineage marker availability, these observations were made only for the NB4-2 lineage. Recent findings reveal that Klu is necessary for larval neuroblast growth and self-renewal. We have extended the study of Klu to the well-known embryonic NB5-6T lineage and describe a novel role for Klu in the Drosophila embryonic CNS. Our results demonstrate that Klu is expressed specifically in the postmitotic Ap4/FMRFa neuron, promoting its differentiation through the initiation of BMP signaling. Our findings indicate a pleiotropic function of Klu in Ap cluster specification in general and particularly in Ap4 neuron differentiation, indicating that Klu is a multitasking transcription factor. Finally, our studies indicate that a transitory downregulation of klu is crucial for the specification of the Ap4/FMRFa neuron. Similar to WT1, klu seems to have either self-renewal or differentiation-promoting functions, depending on the developmental context.
dc.description.departmentDepto. de Biología Celular
dc.description.facultyFac. de Ciencias Biológicas
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Ciencia e Innovación (España)
dc.description.sponsorshipSwedish Research Council
dc.description.sponsorshipSwedish Strategic Research Foundation
dc.description.sponsorshipKnut and Alice Wallenberg Foundation
dc.description.sponsorshipSwedish Brain Foundation
dc.description.sponsorshipSwedish Cancer Foundation
dc.description.sponsorshipSwedish Royal Academy of Sciences
dc.description.statuspub
dc.identifier.citationLosada-Pérez, María, et al. «Klumpfuss Controls FMRFamide Expression by Enabling BMP Signaling within the NB5-6 Lineage». Development, vol. 140, n.o 10, mayo de 2013, pp. 2181-89. https://doi.org/10.1242/dev.089748.
dc.identifier.doi10.1242/dev.089748
dc.identifier.essn0950-1991
dc.identifier.issn1477-9129
dc.identifier.officialurlhttps://doi.org/10.1242/dev.089748
dc.identifier.relatedurlhttp://hdl.handle.net/10486/660449
dc.identifier.urihttps://hdl.handle.net/20.500.14352/94800
dc.issue.number10
dc.journal.titleDevelopment
dc.language.isoeng
dc.publisherThe Company of Biologist
dc.relation.projectIDBFU-2008-04683-C02-02
dc.rights.accessRightsopen access
dc.subject.cdu577.2
dc.subject.keywordDrosophila
dc.subject.keywordKlumpfuss
dc.subject.keywordTerminal differentiation
dc.subject.keywordBMP signaling
dc.subject.keywordNeuropeptidergic cell identity
dc.subject.keywordFMRFa
dc.subject.ucmBiología molecular (Biología)
dc.subject.unesco2415 Biología Molecular
dc.titleKlumpfuss controls FMRFamide expression by enabling BMP signaling within the NB5-6 lineage
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number140
dspace.entity.typePublication
relation.isAuthorOfPublicatione070a479-c74f-4d00-8e8e-bbc25e18750e
relation.isAuthorOfPublication.latestForDiscoverye070a479-c74f-4d00-8e8e-bbc25e18750e

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