The MAPK1/3 pathway is essential for the deregulation of autophagy observed in G2019S LRRK2 mutant fibroblasts

Simple item page
dc.contributor.authorBravo San Pedro, José Manuel
dc.contributor.authorGómez-Sánchez, Rubén
dc.contributor.authorNiso-Santano, Mireia
dc.contributor.authorPizarro-Estrella, Elisa
dc.contributor.authorAiastui-Pujana, Ana
dc.contributor.authorGorostidi, Ana
dc.contributor.authorCliment, Vicente
dc.contributor.authorLópez de Maturana, Rakel
dc.contributor.authorSanchez-Pernaute, Rosario
dc.contributor.authorLópez de Munain, Adolfo
dc.contributor.authorFuentes, José M.
dc.contributor.authorGonzález Polo, Rosa A.
dc.date.accessioned2025-12-15T08:07:30Z
dc.date.available2025-12-15T08:07:30Z
dc.date.issued2012-10
dc.description.abstractThe link between the deregulation of autophagy and cell death processes can be essential in the development of several neurodegenerative diseases, such as Parkinson disease (PD). However, the molecular mechanism of deregulation of this degradative process in PD patients is unknown. The leucine-rich repeat kinase 2 (LRRK2) gene is related to PD and its implication in autophagy regulation has been described. Our recent work shows that the presence of the G2019S LRRK2 mutation, one of the most prevalent in LRRK2, is accompanied by a deregulation of autophagy basal levels dependent on the MAPK1/3 (ERK2/1) pathway.
dc.description.departmentDepto. de Fisiología
dc.description.facultyFac. de Medicina
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Economía y Competitividad (Spain)
dc.description.sponsorshipInstituto de Salud Carlos III (ISCIII)
dc.description.sponsorshipCIBERNED (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas)
dc.description.sponsorshipJunta de Extremadura
dc.description.sponsorshipFUNDESALUD
dc.description.statuspub
dc.identifier.citationBravo-San Pedro JM, Gómez-Sánchez R, Niso-Santano M, Pizarro-Estrella E, Aiastui-Pujana A, Gorostidi A, Climent V, López de Maturana R, Sanchez-Pernaute R, López de Munain A, Fuentes JM, González-Polo RA. The MAPK1/3 pathway is essential for the deregulation of autophagy observed in G2019S LRRK2 mutant fibroblasts. Autophagy. 2012 Oct;8(10):1537-1539. doi:10.4161/auto.21270.
dc.identifier.doi10.4161/auto.21270
dc.identifier.officialurlhttps://doi.org/10.4161/auto.21270
dc.identifier.pmid22914360
dc.identifier.relatedurlhttps://www.tandfonline.com/doi/full/10.4161/auto.21270
dc.identifier.urihttps://hdl.handle.net/20.500.14352/128894
dc.issue.number10
dc.journal.titleAutophagy
dc.language.isoeng
dc.page.final1539
dc.page.initial1537
dc.publisherTaylor & Francis
dc.rights.accessRightsopen access
dc.subject.cdu616.831-002
dc.subject.keywordAutophagy
dc.subject.keywordLRRK2
dc.subject.keywordG2019S
dc.subject.keywordMAPK1/3
dc.subject.keywordParkinson disease
dc.subject.ucmFisiología
dc.subject.ucmNeurociencias (Medicina)
dc.subject.unesco2411 Fisiología Humana
dc.titleThe MAPK1/3 pathway is essential for the deregulation of autophagy observed in G2019S LRRK2 mutant fibroblasts
dc.typejournal article
dc.type.hasVersionAM
dc.volume.number8
dspace.entity.typePublication
relation.isAuthorOfPublication9ba7067d-d334-47dd-8c68-451c794165a2
relation.isAuthorOfPublication.latestForDiscovery9ba7067d-d334-47dd-8c68-451c794165a2

Download

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
The MAPK1_3 pathway is essential for the deregulation of autophagy observed in G2019S LRRK2 mutant fibroblasts.pdf
Size:
942.43 KB
Format:
Adobe Portable Document Format
Download

Collections

Artículos