Ru(II) and Ir(III) phenanthroline-based photosensitisers bearing o-carborane: PDT agents with boron carriers for potential BNCT

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dc.contributor.authorConway-Kenny, Robert
dc.contributor.authorFerrer-Ugalde, Albert
dc.contributor.authorCareta, Oriol
dc.contributor.authorCui, Xiaoneng
dc.contributor.authorZhao, Jianzhang
dc.contributor.authorNogués, Carme
dc.contributor.authorNúñez, Rosario
dc.contributor.authorCabrera González, Justo Enrique
dc.contributor.authorDraper, Sylvia M.
dc.date.accessioned2024-02-02T12:52:35Z
dc.date.available2024-02-02T12:52:35Z
dc.date.issued2021-05-10
dc.description.abstractFour novel transition metal-carborane photosensitisers were prepared by Sonogashira cross-coupling of 1-(4-ethynylbenzyl)-2-methyl-o-carborane (A-CB) with halogenated Ru(II)- or Ir(III)-phenanthroline complexes. The resulting boron-rich complexes with one (RuCB and IrCB) or two carborane cages (RuCB2 and IrCB2) were spectroscopically characterised, and their photophysical properties investigated. RuCB displayed the most attractive photophysical properties in solution (λem 635 nm, τT 2.53 μs, and φp 20.4%). Nanosecond time-resolved transient absorption studies were used to explore the 3MLCT nature of the triplet excited states, and the highest singlet oxygen quantum yields (ΦΔ) were obtained for the mono-carborane-phenanthroline complexes (RuCB: 52% and IrCB: 25%). None of the complexes produce dark toxicity in SKBR-3 cells after incubation under photodynamic therapy (PDT) conditions. Remarkably, mono-carboranes RuCB and IrCB were the best internalised by the SKBR-3 cells, demonstrating the first examples of tris-bidentate transition metal-carborane complexes acting as triplet photosensitisers for PDT with a high photoactivity; RuCB or IrCB killed ∼50% of SKBR-3 cells at 10 μM after irradiation. Therefore, the high-boron content and the photoactive properties of these photosensitisers make them potential candidates as dual anti-cancer agents for PDT and Boron Neutron Capture Therapy (BNCT).
dc.description.departmentDepto. de Química en Ciencias Farmacéuticas
dc.description.facultyFac. de Farmacia
dc.description.refereedTRUE
dc.description.sponsorshipScience Foundation Ireland
dc.description.sponsorshipMinisterio de Ciencia, Innovación y Universidades(España)
dc.description.sponsorshipAgencia Estatal de Investigación
dc.description.sponsorshipGeneralitat de Cataluña
dc.description.statuspub
dc.identifier.doi10.1039/d1bm00730k
dc.identifier.officialurlhttps://doi.org/10.1039/d1bm00730k
dc.identifier.urihttps://hdl.handle.net/20.500.14352/98286
dc.journal.titleBiomaterials Science
dc.language.isoeng
dc.page.final5702
dc.page.initial5691
dc.publisherRoyal Society of Chemistry
dc.relation.projectIDinfo:eu-repo/grantAgreement/MCIN/MAT2017-86357-C3-3-R
dc.relation.projectIDinfo:eu-repo/grantAgreement/PID2019-106832RB- 100/AEI/10.13039/501100011033
dc.relation.projectIDinfo:eu-repo/grantAgreement/2017-SGR-503
dc.relation.projectIDinfo:eu-repo/grantAgreement/2017-SGR-1720
dc.relation.projectIDinfo:eu-repo/grantAgreement/CEX2019-000917-S. R. C.-K.
dc.rights.accessRightsrestricted access
dc.subject.ucmQuímica
dc.subject.unesco23 Química
dc.titleRu(II) and Ir(III) phenanthroline-based photosensitisers bearing o-carborane: PDT agents with boron carriers for potential BNCT
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number9
dspace.entity.typePublication
relation.isAuthorOfPublication5fdca92d-6eb3-4245-bdfe-1bf73af9881b
relation.isAuthorOfPublication.latestForDiscovery5fdca92d-6eb3-4245-bdfe-1bf73af9881b
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