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Lactoferrin Levels in Tears are Increased by the Topical Application of Diadenosine Tetraphosphate

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dc.contributor.authorLoma Lozano, Patricia
dc.contributor.authorGuzmán Aránguez, Ana Isabel
dc.contributor.authorPérez de Lara, María Jesús
dc.contributor.authorPintor, Jesús
dc.date.accessioned2023-06-17T21:52:07Z
dc.date.available2023-06-17T21:52:07Z
dc.date.issued2016-09
dc.descriptionReceived 20 July 2015 ; Revised 8 October 2015 ; Accepted 18 October 2015
dc.description.abstractPurpose: This study was undertaken to determine the effect of the topical application of diadenosine tetraphosphate on lactoferrin levels in rabbit tears. Methods: Diadenosine tetraphosphate was topically instilled in a single-dose, tear samples were collected by micropipette and lactoferrin was measured by Enzyme-Linked ImmunoSorbent Assay (ELISA). Results: The concentration of lactoferrin in rabbit tears was significantly increased 1 h after diadenosine tetraphosphate application, remaining elevated for 3 h more. This effect was blocked by P2 receptors antagonists. Conclusions: Topical application of diadenosine tetraphosphate stimulates the secretion of lactoferrin in rabbit tears through P2 receptor activation.
dc.description.departmentUnidad Docente de Bioquímica y Biología Molecular
dc.description.facultyFac. de Óptica y Optometría
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Ciencia e Innovación (MICINN)
dc.description.sponsorshipRETICS (Redes Temáticas de Investigación Cooperativa en Salud)
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/41803
dc.identifier.doi10.3109/02713683.2015.1113431
dc.identifier.issn0271-3683
dc.identifier.officialurlhttp://dx.doi.org/10.3109/02713683.2015.1113431
dc.identifier.urihttps://hdl.handle.net/20.500.14352/17684
dc.issue.number9
dc.journal.titleCurrent Eye Research
dc.language.isoeng
dc.page.final1152
dc.page.initial1150
dc.publisherTaylor & Francis
dc.relation.projectIDSAF2013-44416-R
dc.relation.projectIDRD12/0034/0003
dc.rights.accessRightsrestricted access
dc.subject.cdu617.764
dc.subject.cdu577.15
dc.subject.keywordDiadenosine tetraphosphate
dc.subject.keywordLactoferrin
dc.subject.keywordPurinergic receptors
dc.subject.keywordTear film
dc.subject.ucmBioquímica (Medicina)
dc.subject.ucmAnatomía ocular
dc.titleLactoferrin Levels in Tears are Increased by the Topical Application of Diadenosine Tetraphosphate
dc.typejournal article
dc.volume.number41
dspace.entity.typePublication
relation.isAuthorOfPublicationd1e44010-b3d9-4270-892d-a1f97a4db789
relation.isAuthorOfPublication.latestForDiscoveryd1e44010-b3d9-4270-892d-a1f97a4db789

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