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Neuroprotective role of sphingosine-1-phosphate in L-BMAA treated neuroblastoma cells (SH-SY5Y)

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dc.contributor.authorMuñoz Sáez, Emma
dc.contributor.authorMunck García, Estefanía de
dc.contributor.authorArahuetes Portero, Rosa María
dc.contributor.authorVicente, Francisca
dc.contributor.authorOrtiz López, Francisco Javier
dc.contributor.authorCantizani, Juan
dc.contributor.authorGómez Miguel, Begoña
dc.date.accessioned2023-06-18T05:48:25Z
dc.date.available2023-06-18T05:48:25Z
dc.date.issued2015-04-23
dc.description.abstractSphingosine-1-phosphate (S1P) is a bioactive lipid which regulates proliferation, cell migration, survival and differentiation by specific receptors activation. We studied its effects on L-BMAA treated neuroblastoma cells (SH-SY5Y), an amino acid that can trigger neurodegenerative diseases such as amyotrophic lateral sclerosis/Parkinson dementia complex (ALS/PDC). We found that S1P protects from necrosis and prevents the GSK3 increasing as long as the PI3K/AKT pathway is active. Moreover, GSK3 inhibition protects against neuronal death caused by L-BMAA.
dc.description.departmentSección Deptal. de Bioquímica y Biología Molecular (Biológicas)
dc.description.facultyFac. de Ciencias Biológicas
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Economía y Competitividad (MINECO)
dc.description.sponsorshipFUNDELA (Spanish ALS Foundation)
dc.description.sponsorshipMedical Chemistry department of CSIC (Spanish National Research Council)
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/43232
dc.identifier.doi10.1016/j.neulet.2015.03.010
dc.identifier.issn0304-3940
dc.identifier.officialurlhttps://www.journals.elsevier.com/neuroscience-letters/
dc.identifier.urihttps://hdl.handle.net/20.500.14352/23381
dc.journal.titleNeuroscience Letters
dc.language.isoeng
dc.page.final89
dc.page.initial83
dc.publisherElsevier
dc.relation.projectIDPPT-300000-2009-11
dc.rights.accessRightsrestricted access
dc.subject.cdu577.2
dc.subject.cdu547.915
dc.subject.keywordSH-SY5Y
dc.subject.keywordSphingosine-1-phosphate
dc.subject.keywordβ-N-methylamine-l-alanine
dc.subject.keywordNeuroprotection
dc.subject.keywordGSK3
dc.subject.ucmBiología
dc.subject.ucmBiología molecular (Biología)
dc.subject.unesco24 Ciencias de la Vida
dc.subject.unesco2415 Biología Molecular
dc.titleNeuroprotective role of sphingosine-1-phosphate in L-BMAA treated neuroblastoma cells (SH-SY5Y)
dc.typejournal article
dc.volume.number593
dspace.entity.typePublication
relation.isAuthorOfPublication96dbf850-4b9a-4ce3-85ba-28062a7c399d
relation.isAuthorOfPublication09dd64de-3892-481f-a431-c28e91690937
relation.isAuthorOfPublication.latestForDiscovery96dbf850-4b9a-4ce3-85ba-28062a7c399d

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