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Stimulation of ALK by the growth factor midkine renders glioma cells resistant to autophagy-mediated cell death

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dc.contributor.advisorVelasco Díez, Guillermo
dc.contributor.authorLorente Pérez, María Del Mar
dc.contributor.authorTorres, Sofia
dc.contributor.authorSalazar Roa, María
dc.contributor.authorCarracedo, Arkaitz
dc.contributor.authorHernández Tiedra, Sonia
dc.contributor.authorRodríguez Fornés, Fátima
dc.contributor.authorGarcía Taboada, Elena
dc.contributor.authorMeléndez, Bárbara
dc.contributor.authorMollejo, Manuela
dc.contributor.authorCampos Martín, Yolanda
dc.contributor.authorBarcia Albacar, Juan Antonio
dc.contributor.authorGuzmán Pastor, Manuel
dc.contributor.authorVelasco Díez, Guillermo
dc.date.accessioned2024-01-31T16:33:42Z
dc.date.available2024-01-31T16:33:42Z
dc.date.issued2011
dc.description.abstractΔ9-tetrahydrocannabinol (THC), the main active component of marijuana, promotes cancer cell death via autophagy stimulation. We find that activation of the tyrosine kinase receptor ALK by its ligand midkine interferes with the signaling mechanism by which THC promotes autophagy-mediated glioma cell death.en
dc.description.departmentDepto. de Bioquímica y Biología Molecular
dc.description.facultyFac. de Ciencias Biológicas
dc.description.refereedTRUE
dc.description.statuspub
dc.identifier.citationLorente, M., Torres, S., Salazar, M., Carracedo, A., Hernández-Tiedra, S., Rodríguez-Fornés, F., … Velasco, G. (2011). Stimulation of ALK by the growth factor midkine renders glioma cells resistant to autophagy-mediated cell death. Autophagy, 7(9), 1071–1073. https://doi.org/10.4161/auto.7.9.15866
dc.identifier.doi10.4161/auto.7.9.15866
dc.identifier.essn1554-8635
dc.identifier.issn1554-8627
dc.identifier.officialurlhttps://doi.org/10.4161/auto.7.9.15866
dc.identifier.urihttps://hdl.handle.net/20.500.14352/97335
dc.issue.number9
dc.journal.titleAutophagy
dc.language.isoeng
dc.page.final1073
dc.page.initial1071
dc.publisherTaylor & Francis
dc.rights.accessRightsrestricted access
dc.subject.keywordAutophagy
dc.subject.keywordGlioma
dc.subject.keywordCannabinoids
dc.subject.keywordMidkine
dc.subject.keywordALK
dc.subject.keywordER stress
dc.subject.keywordTRB3
dc.subject.ucmBiología celular (Biología)
dc.subject.unesco2403 Bioquímica
dc.titleStimulation of ALK by the growth factor midkine renders glioma cells resistant to autophagy-mediated cell deathen
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number7
dspace.entity.typePublication
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