Obesity and telomere status in the prognosis of patients with colorectal cancer submitted to curative intention surgical treatment

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dc.contributor.authorGarcía Martínez, Sergio
dc.contributor.authorGonzález Gamo, Daniel
dc.contributor.authorFernández Marcelo, Tamara
dc.contributor.authorTesolato, Sofía
dc.contributor.authorDe La-Serna Esteban, Sofía Cristina
dc.contributor.authorDomínguez Serrano, María Inmaculada
dc.contributor.authorCano Valderrama, Óscar
dc.contributor.authorBarabash Bustelo, Ana
dc.contributor.authorJuan Chocano, María Del Carmen De
dc.contributor.authorTorres García, Antonio José
dc.contributor.authorIniesta Serrano, María Pilar
dc.date.accessioned2023-12-20T13:07:43Z
dc.date.available2023-12-20T13:07:43Z
dc.date.issued2021
dc.description.abstractThe risk of colorectal cancer (CRC) development has been associated with telomere dysfunction and obesity. However, clinical relevance of these parameters in CRC prognosis is not clear. Therefore, the aim of the present study was to evaluate the impact of obesity and telomere status in the prognosis of patients affected by CRC and submitted to curative surgical treatment. According to published data, this is the first work in which obesity and telomere status are jointly considered in relation to CRC prognosis. A prospective study including 162 patients with CRC submitted to curative surgical treatment was performed. Subjects were classified according to their BMI. Telomere status was established through telomere length and telomerase activity evaluation. Statistical analyses were performed using the SPSS software package version 22. Telomere shortening was inversely associated with BMI in patients with CRC. Notably, among patients with CRC, subjects with obesity exhibited less shortening of tumor telomeres than non‑obese patients (P=0.047). Patients with shorter telomeres, both in the tumor (median telomere length <6.5 kb) and their non‑tumor paired tissues (median telomere length <7.1 kb), had the best clinical evolution, regardless of the Dukes' stage of cancers (P=0.025, for tumor samples; P=0.003, for non‑tumor samples). Additionally, subjects with a BMI >31.85 kg/m2 showed the worse clinical outcomes compared with subjects with other BMI values. Interestingly, the impact of BMI showed sex dependence, since only the group of men displayed significant differences in CRC prognosis in relation to obesity status (P=0.037). From the results of the present study, based on a multivariate prediction model to establish prognosis, it was concluded that telomere length is a useful biomarker to predict prognosis in patients with CRC. Regardless of BMI values, the improved clinical evolution was associated with shorter telomeres. The impact of BMI seems to be associated with other factors, such as sex.
dc.description.departmentDepto. de Bioquímica y Biología Molecular
dc.description.departmentDepto. de Cirugía
dc.description.departmentDepto. de Medicina
dc.description.facultyFac. de Farmacia
dc.description.facultyFac. de Medicina
dc.description.refereedTRUE
dc.description.sponsorshipInstituto Carlos III
dc.description.sponsorshipEuropean Commission
dc.description.statuspub
dc.identifier.citationGarcía-Martínez S, González-Gamo D, Fernández-Marcelo T, Tesolato S, De la Serna S, Domínguez-Serrano I, Cano-Valderrama O, Barabash A, De Juan C, Torres-García A, Iniesta P. Obesity and telomere status in the prognosis of patients with colorectal cancer submitted to curative intention surgical treatment. Mol Clin Oncol. 2021, 15(3):184. doi: 10.3892/mco.2021.2346.
dc.identifier.doi10.3892/mco.2021.2346
dc.identifier.issn2049-9450
dc.identifier.officialurlhttps://doi.org/10.3892/mco.2021.2346
dc.identifier.urihttps://hdl.handle.net/20.500.14352/91601
dc.issue.number3
dc.journal.titleMolecular and Clinical Onclogy
dc.language.isoeng
dc.page.initial184
dc.publisherSpandidos Publications
dc.relation.projectIDinfo:eu-repo/grantAgreement/PI15/01199
dc.relation.projectIDinfo:eu-repo/grantAgreement/PI19/00073
dc.rights.accessRightsopen access
dc.subject.cdu616.34-006
dc.subject.keywordObesity
dc.subject.keywordTelomere
dc.subject.keywordTelomerase
dc.subject.keywordColorectal cancer
dc.subject.keywordPrognosis
dc.subject.ucmOncología
dc.subject.ucmEndocrinología
dc.subject.unesco24 Ciencias de la Vida
dc.titleObesity and telomere status in the prognosis of patients with colorectal cancer submitted to curative intention surgical treatment
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number15
dspace.entity.typePublication
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