Retinal Thickness Changes Over Time in a Murine AD Model APPNL-F/NL-F

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dc.contributor.authorGarcía Martín, Elena Salobrar
dc.contributor.authorLópez Cuenca, Inés
dc.contributor.authorSánchez Puebla, Lídia
dc.contributor.authorHoz Montañana, María Rosa de
dc.contributor.authorFernández Arrabal, José A.
dc.contributor.authorRamírez Sebastián, Ana Isabel
dc.contributor.authorBravo Ferrer, Isbel
dc.contributor.authorMedina Alonso, Violeta
dc.contributor.authorMoro Sánchez, María Ángeles
dc.contributor.authorSaido, Takaomi C.
dc.contributor.authorSaito, Takashi
dc.contributor.authorSalazar Corral, Juan José
dc.contributor.authorRamirez Sebastian, Jose Manuel
dc.date.accessioned2023-06-17T08:57:52Z
dc.date.available2023-06-17T08:57:52Z
dc.date.issued2021-01-15
dc.descriptionReceived: 03 November 2020; Accepted: 15 December 2020; Published: 15 January 2021.
dc.description.abstractBackground: Alzheimer’s disease (AD) may present retinal changes before brain pathology, suggesting the retina as an accessible biomarker of AD. The present work is a diachronic study using spectral domain optical coherence tomography (SD-OCT) to determine the total retinal thickness and retinal nerve fiber layer (RNFL) thickness in an APPNL−F/NL−F mouse model of AD at 6, 9, 12, 15, 17, and 20 months old compared to wild type (WT) animals. Methods: Total retinal thickness and RNFL thickness were determined. The mean total retinal thickness was analyzed following the Early Treatment Diabetic Retinopathy Study sectors. RNFL was measured in six sectors of axonal ring scans around the optic nerve. Results: In the APPNL−F/NL−F group compared to WT animals, the total retinal thickness changes observed were the following: (i) At 6-months-old, a significant thinning in the outer temporal sector was observed; (ii) at 15-months-old a significant thinning in the inner temporal and in the inner and outer inferior retinal sectors was noticed; (iii) at 17-months-old, a significant thickening in the inferior and nasal sectors was found in both inner and outer rings; and (iv) at 20-months-old, a significant thinning in the inner ring of nasal, temporal, and inferior retina and in the outer ring of superior and temporal retina was seen. In RNFL thickness, there was significant thinning in the global analysis and in nasal and inner-temporal sectors at 6 months old. Thinning was also found in the supero-temporal and nasal sectors and global value at 20 months old. Conclusions: In the APPNL−F/NL−F AD model, the retinal thickness showed thinning, possibly produced by neurodegeneration alternating with thickening caused by deposits and neuroinflammation in some areas of the retina. These changes over time are similar to those observed in the human retina and could be a biomarker for AD. The APPNL−F/NL−F AD model may help us better understand the different retinal changes during the progression of AD. Keywords: Alzheimer, retina, OCT, mouse model of AD, APPNL-F/NL-F
dc.description.departmentUnidad Docente de Inmunología, Oftalmología y ORL
dc.description.facultyFac. de Óptica y Optometría
dc.description.refereedTRUE
dc.description.sponsorshipInstituto de Salud Carlos III
dc.description.sponsorshipMinisterio de Ciencia e Innovación (MICCIN)
dc.description.sponsorshipLeducq Fundation for Cardiovascular Research
dc.description.sponsorshipUniversidad Complutense de Madrid
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/63726
dc.identifier.doi10.3389/fnagi.2020.625642
dc.identifier.issn1663-4365
dc.identifier.officialurlhttps://doi.org/10.3389/fnagi.2020.625642
dc.identifier.relatedurlhttps://www.frontiersin.org/articles/10.3389/fnagi.2020.625642/full
dc.identifier.urihttps://hdl.handle.net/20.500.14352/7737
dc.journal.titleFrontiers in aging neuroscience
dc.language.isoeng
dc.page.initial12:625642
dc.publisherFrontiers Media
dc.relation.projectIDOFTARED (RD16/0008/0005)
dc.relation.projectIDRETIBRAIN (RED2018-102499-T); PID2019-106581RB-I00
dc.relation.projectIDTNE-19CVD01
dc.relation.projectID(CT42/18-CT43/18)
dc.relation.projectIDFPU17/01023
dc.rightsAtribución 3.0 España
dc.rights.accessRightsopen access
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/es/
dc.subject.cdu616.894-053.9:617.735
dc.subject.cdu617.735-073.75
dc.subject.keywordAlzheimer
dc.subject.keywordretina
dc.subject.keywordOCT
dc.subject.keywordmouse model of AD
dc.subject.keywordAPPNL-F/NL-F
dc.subject.ucmNeurociencias (Medicina)
dc.subject.ucmOftalmología
dc.subject.ucmTécnicas de la imagen
dc.subject.unesco2490 Neurociencias
dc.subject.unesco3201.09 Oftalmología
dc.titleRetinal Thickness Changes Over Time in a Murine AD Model APPNL-F/NL-F
dc.typejournal article
dspace.entity.typePublication
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relation.isAuthorOfPublication.latestForDiscovery554437df-fa3d-41e1-862c-bcdda1dbd67a
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