Klotho Prevents Translocation of NFκB

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dc.book.titleKlotho
dc.contributor.authorBuendía, P.
dc.contributor.authorRamírez, R.
dc.contributor.authorAljama, P.
dc.contributor.authorCarracedo Añón, Julia María
dc.contributor.editorLitwack, Gerald
dc.date.accessioned2026-02-06T16:04:39Z
dc.date.available2026-02-06T16:04:39Z
dc.date.issued2016
dc.descriptionThis work was supported by Plan Nacional de I+D+i Proyectos de Investigación en Salud of Instituto de Salud Carlos III (ISCIII)-Subdirección General de Evaluación, Fondos de desarrollo regional (FEDER) (PI12/01489 and PI14/00806); Junta de Andalucía Grants (P010-CTS-6337, P11-CTS-7352); and Fundación Nefrológica. J.C. was supported by a contract from Fundación de Investigaciones Biomédicas de Córdoba (Servicio Andaluz de Salud, Programa Nicolás Monardes). P.B. is fellow from Consejería de...
dc.description.abstractKlotho protein is a β-glucuronidase capable of hydrolyzing steroid β-glucuronides. Two molecules are produced by the Klotho gene, a membrane bound form and a circulating form. This protein is recognized as an antiaging gene with pleiotropic functions. The activation of cellular systems is associated with the pathogenesis of several chronic and degenerative diseases associated with an inflammatory state. Inflammation is characterized by an activation of NFκB. Klotho suppresses nuclear factor NFκB activation and the subsequent transcription of proinflammatory genes. This review focuses on the current understanding of Klotho protein function and its relationship with NFκB regulation, emphasizing its potential involvement in the pathophysiologic process.
dc.description.departmentDepto. de Genética, Fisiología y Microbiología
dc.description.facultyFac. de Ciencias Biológicas
dc.description.refereedTRUE
dc.description.sponsorshipInstituto de Salud Carlos III
dc.description.sponsorshipJunta de Andalucía
dc.description.sponsorshipFundación Nefrológica
dc.description.sponsorshipFundación de Investigaciones Biomédicas de Córdoba
dc.description.statuspub
dc.identifier.citationBuendía, P., Ramírez, R., Aljama, P., & Carracedo, J. (2016). Klotho prevents translocation of nfκb. En Vitamins & Hormones (Vol. 101, pp. 119-150). Elsevier. https://doi.org/10.1016/bs.vh.2016.02.005
dc.identifier.doi10.1016/bs.vh.2016.02.005
dc.identifier.isbn9780128048191
dc.identifier.issn0083-6729
dc.identifier.officialurlhttps://doi.org/10.1016/bs.vh.2016.02.005
dc.identifier.urihttps://hdl.handle.net/20.500.14352/131839
dc.language.isoeng
dc.page.final150
dc.page.initial119
dc.publisherElsevier
dc.relation.ispartofseriesVitamins and Hormones
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//PI12%2F01489/ES/Inflamación y enfermedad vascular calcificante en la uremia: Identificación de nuevas dianas diagnósticas y terapéuticas/
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//PI14%2F00806/ES/Papel de microRNAs vehiculados por microparticulas de células senescentes en la enfermedad vascular asociada a la enfermedad renal crónica por nefropatía diabética/
dc.rights.accessRightsmetadata only access
dc.subject.cdu577.1
dc.subject.cdu612.017
dc.subject.keywordChronic kidney disease
dc.subject.keywordFgf-23
dc.subject.keywordInflammation
dc.subject.keywordKlotho
dc.subject.keywordNfκb
dc.subject.keywordOxidative stress
dc.subject.keywordSenescence
dc.subject.ucmBioquímica (Biología)
dc.subject.ucmInmunología
dc.subject.unesco2403 Bioquímica
dc.subject.unesco2412 Inmunología
dc.titleKlotho Prevents Translocation of NFκB
dc.typebook part
dc.type.hasVersionVoR
dc.volume.number101
dspace.entity.typePublication
relation.isAuthorOfPublication447f8cb2-a0b7-4398-9c77-baff3dd853e7
relation.isAuthorOfPublication.latestForDiscovery447f8cb2-a0b7-4398-9c77-baff3dd853e7

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