Brain repair after ischemic stroke: role of neurotransmitters in post-ischemic neurogenesis
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2012
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Viguera (neurologia.com)
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Sánchez-Mendoza E, Bellver-Landete V, González MP, Merino JJ, Martínez-Murillo R, Oset-Gasque MJ. Neurorrestauración tras la isquemia cerebral: papel de los neurotransmisores en la neurogénesis postisquémica [Brain repair after ischemic stroke: role of neurotransmitters in post-ischemic neurogenesis]. Rev Neurol. 2012 Nov 1;55(9):533-42. Spanish. PMID: 23111992. Copy Download .nbib
Abstract
Abstract
Introduction: Brain ischemia and reperfusion produce alterations in the microenvironment of the parenchyma, including ATP depletion, ionic homeostasis alterations, inflammation, release of multiple cytokines and abnormal release of neurotransmitters. As a consequence, the induction of proliferation and migration of neural stem cells towards the peri-infarct region occurs.
Development: The success of new neurorestorative treatments for damaged brain implies the need to know, with greater accuracy, the mechanisms in charge of regulating adult neurogenesis, both under physiological and pathological conditions. Recent evidence demonstrates that many neurotransmitters, glutamate in particular, control the subventricular zone, thus being part of the complex signalling network that influences the production of new neurons.
Conclusion: Neurotransmitters provide a link between brain activity and subventricular zone neurogenesis. Therefore, a deeper knowledge of the role of neurotransmitters systems, such as glutamate and its transporters, in adult neurogenesis, may provide a valuable tool to be used as a neurorestorative therapy in this pathology.