Influence of zoledronic acid and pamidronate on tooth eruption in children with osteogenesis imperfecta

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dc.contributor.authorRío Cantero, Natalia del
dc.contributor.authorMourelle Martínez, Rosa
dc.contributor.authorSagastizabal Cardelús, Belén
dc.contributor.authorNova García, Manuel Joaquín De
dc.date.accessioned2024-03-13T13:02:45Z
dc.date.available2024-03-13T13:02:45Z
dc.date.issued2024-03-06
dc.description.abstractIntroduction Osteogenesis imperfecta (OI) is a congenital disease comprising a heterogeneous group of inherited connective tissue disorders. The main treatment in children is bisphosphonate therapy. Previous animal studies have shown that bisphosphonates delay tooth eruption. The aim of this study is to determine whether patients with OI treated with pamidronate and/or zoledronic acid have a delayed eruption age compared to a control group of healthy children. Methods An ambispective longitudinal cohort study evaluating the age of eruption of the first stage mixed dentition in a group of children with OI (n = 37) all treated with intravenous bisphosphonates compared with a group of healthy children (n = 89). Within the study group, the correlation (Pearson correlation test) between the type of medication administered (pamidronate and/or zoledronic acid) and the chronology of tooth eruption is established, as well as the relationship between the amount of cumulative dose received and tooth eruption. Results The age of eruption of the study group was significantly delayed compared to the age of eruption of the control group for molars and lateral incisors (p < 0.05). Patients who received higher cumulative doses had a delayed eruption age compared to those with lower cumulative doses (p < 0.05). There is a high positive correlation between age of delayed tooth eruption and Zoledronic acid administration. Conclusion Patients with OI have a delayed eruption of the 1st stage mixed dentition compared to a control group of healthy children. This delayed eruption is directly related to the cumulative dose of bisphosphonates and the administration of zoledronic ac.
dc.description.departmentDepto. de Especialidades Clínicas Odontológicas
dc.description.facultyFac. de Odontología
dc.description.refereedTRUE
dc.description.statusinpress
dc.identifier.citationRío Cantero N del, Mourelle Martínez M.R., Sagastizabal Cardelús B., Nova García J M de. Influence of zoledronic acid and pamidronate on tooth eruption in children with osteogenesis imperfecta, Bone, 2023 Mar 6; 117069
dc.identifier.doihttps://doi.org/10.1016/j.bone.2024.117069
dc.identifier.essn1873-2763
dc.identifier.issn8756-3282
dc.identifier.officialurlhttps://www.sciencedirect.com/science/article/pii/S8756328224000589?via%3Dihub
dc.identifier.urihttps://hdl.handle.net/20.500.14352/102192
dc.journal.titleBone
dc.language.isoeng
dc.page.initial117069
dc.publisherElsevier
dc.rightsAttribution-ShareAlike 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-sa/4.0/
dc.subject.cdu616.314-053.2
dc.subject.cdu616.71
dc.subject.keywordOsteogenesis imperfecta
dc.subject.keywordBisphosphonates
dc.subject.keywordDental eruption
dc.subject.keywordZoledronic acid
dc.subject.keywordPamidronate
dc.subject.ucmCiencias Biomédicas
dc.subject.ucmOdontología (Odontología)
dc.subject.ucmOdontología infantil
dc.subject.ucmFarmacología (Medicina)
dc.subject.unesco32 Ciencias Médicas
dc.subject.unesco3213.13 Ortodoncia-Estomatología
dc.subject.unesco3207.14 Osteopatología
dc.titleInfluence of zoledronic acid and pamidronate on tooth eruption in children with osteogenesis imperfecta
dc.typejournal article
dc.type.hasVersionAM
dspace.entity.typePublication
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relation.isAuthorOfPublication.latestForDiscoverycd7b79cd-2c53-462f-9100-f48e080852a1
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