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New procedures for the synthesis of heterocyclic substituted and 2,4-difunctionalized pyrimidines

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Abstract

N-Tosyl-2- and -3-acetylpyrrols 1 or N-tosyl-2-pyrrolidone 5 were condensed with cyano compounds in the presence of triflic anhydride (Tf2O) to yield heteroarylpyrimidines. 2,4 Difunctionalized pyrimidines were obtained by reaction of the corresponding 2,4-bis(methylsulfonyl)pyrimidines with nucleophiles.

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Received in UK 15 March 1996; revised 2 April 1996; accepted 12 April 1996

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