High-fat diet alters PAS kinase regulation by fasting and feeding in liver

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dc.contributor.authorPérez García, Ana
dc.contributor.authorDongil, Pilar
dc.contributor.authorHurtado Carneiro, Verónica
dc.contributor.authorBlázquez Fernández, Enrique
dc.contributor.authorSanz Miguel, María Del Carmen
dc.contributor.authorÁlvarez García, Elvira
dc.date.accessioned2024-08-28T11:12:03Z
dc.date.available2024-08-28T11:12:03Z
dc.date.issued2018-07
dc.descriptionComplutense University–Banco Santander Funding Programme for the Creation and Consolidation of Research Teams (GR3/14) Fondos FEDER
dc.description.abstractThe prevalence of overweight and obesity in the population, along with their associated complications, is a major factor contributing to increased morbidity and mortality in developed countries. The liver is a vital organ for maintaining metabolic homeostasis, especially in the adjustment periods in fasting and feeding. Per-Arnt-Sim (PAS) kinase (PASK) controls glucose homeostasis and energy metabolism in response to nutritional status. PASK-deficient mice with a high-fat diet (HFD) resist the development of obesity and hepatic steatosis, with improved insulin sensitivity. We have investigated the regulation of the PASK expression in an HFD, as well as its role in adapting to fasting and feeding conditions. PASK-deficient mice with an HFD record improved parameters for the following: body weight, glucose tolerance, insulin resistance and serum lipid parameters. An HFD alters the down-regulation of Pask expression produced by fasting, as normally happens in a standard-fat diet. PASK deficiency blocks or diminishes the expression of many genes overexpressed in HFD-fed mice, such as the following: transcription factors involved in the regulation of gluconeogenic enzymes, the transport of fatty acid into mitochondria, beta-oxidation and de novo lipogenesis. PASK also regulates gene expression posttranscriptionally through the short noncoding RNAs involved in lipid metabolism and glucose homeostasis. The expression of miR-33a and miR-143 changes in PASK-deficient mice with an HFD. Thus, PASK-deficient mice improved their adaptation to feeding/fasting through a highly regulated molecular mechanism that controls the expression and function of the transcription factors, enzymes and miRNAs involved in glucose and insulin signaling.
dc.description.departmentDepto. de Fisiología
dc.description.departmentDepto. de Biología Celular
dc.description.departmentDepto. de Bioquímica y Biología Molecular
dc.description.facultyFac. de Medicina
dc.description.refereedTRUE
dc.description.sponsorshipEuropean Commission
dc.description.sponsorshipMinisterio de Economía, Comercio y Empresa (España)
dc.description.sponsorshipUniversidad Complutense de Madrid
dc.description.sponsorshipMutua Madrileña Medical Research Foundation
dc.description.sponsorshipInstituto de Salud Carlos III
dc.description.sponsorshipBanco Santander
dc.description.statuspub
dc.identifier.citationPérez-García A, Dongil P, Hurtado-Carneiro V, Blázquez E, Sanz C, Álvarez E. High-fat diet alters PAS kinase regulation by fasting and feeding in liver. J Nutr Biochem. 2018 Jul;57:14-25. doi: 10.1016/j.jnutbio.2018.03.003. Epub 2018 Mar 12. PMID: 29649689.
dc.identifier.doi10.1016/j.jnutbio.2018.03.003
dc.identifier.issn1873-4847
dc.identifier.officialurlhttps://doi.org/10.1016/j.jnutbio.2018.03.003
dc.identifier.relatedurlhttps://www.sciencedirect.com/science/article/pii/S0955286317310483?via%3Dihub
dc.identifier.urihttps://hdl.handle.net/20.500.14352/107728
dc.journal.titleThe Journal of Nutritional Biochemistry
dc.language.isoeng
dc.page.final25
dc.page.initial14
dc.publisherElsevier
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/Programa Estatal de Investigación, Desarrollo e Innovación Orientada a los Retos de la Sociedad 2016/RTC-2016-4823-1
dc.rights.accessRightsrestricted access
dc.subject.cdu577.2
dc.subject.keywordGlucokinase
dc.subject.keywordLipogenesis
dc.subject.keywordHepatic metabolism
dc.subject.keywordMetabolic sensors
dc.subject.keywordObesity
dc.subject.ucmCiencias Biomédicas
dc.subject.unesco24 Ciencias de la Vida
dc.titleHigh-fat diet alters PAS kinase regulation by fasting and feeding in liver
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number57
dspace.entity.typePublication
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