Low-Dose Radiation Therapy in the Management of Coronavirus Disease 2019 (COVID-19) Pneumonia (LOWRAD-Cov19): Preliminary Report

Simple item page
dc.contributor.authorNoelia Sanmamed
dc.contributor.authorAlcántara Carrió, María Del Pino
dc.contributor.authorElena Cerezo
dc.contributor.authorGaztañaga Boronat, Miren
dc.contributor.authorCabello Clotet, Noemí
dc.contributor.authorSara Gómez
dc.contributor.authorBustos García De Castro, Ana María
dc.contributor.authorMercedes Duffort
dc.contributor.authorAnxela Doval
dc.contributor.authorCorona Sánchez, Juan Antonio
dc.contributor.authorGabriel Rodriguez
dc.contributor.authorOrtuño Andériz, Francisco
dc.contributor.authorCastro Fernández, Javier De
dc.contributor.authorManuel Enrique Fuentes
dc.contributor.authorAlvaro Sanz
dc.contributor.authorAmanda López
dc.contributor.authorPérez Vázquez, José Manuel
dc.date.accessioned2024-02-08T13:54:49Z
dc.date.available2024-02-08T13:54:49Z
dc.date.issued2021-03-15
dc.descriptionPubMed Disclaimer
dc.description.abstractPurpose: Low-dose radiation therapy (LD-RT) has been shown to have an anti-inflammatory effect, and preliminary results suggest it is feasible to treat patients with coronavirus disease 2019 (COVID-19) pneumonia. Materials and methods: We conducted a prospective, single-arm, phase 1/2 clinical trial enrolling patients aged ≥50 years, who were coronavirus disease 2019 (COVID-19) positive, at phase 2 or 3 with lung involvement at imaging study and oxygen requirement. Patients received 100 cGy to total lungs in a single fraction. Primary outcome was radiologic response using severity and extension score on baseline computed tomography (CT), at days 3 and 7 after LD-RT. Secondary outcomes were toxicity using Common Terminology Criteria for Adverse Events v.5.0, duration of hospitalization, blood work evolution, and oxygen requirements using SatO2/FiO2 index (SAFI), at days 3 and 7 after LD-RT. Results: Nine patients were included. Median age was 66 (interquartile range, 57-77). Severity score was stable or decreased in the third CT but was not statistically significant (P = .28); however, there were statistically significant changes in the extension score (P = .03). SAFI index significantly improved 72 hours and 1 week after LD-RT (P = .01). Inflammatory blood parameters decreased 1 week after RT compared with baseline; only lactate dehydrogenase decreased significantly (P = .04). Two patients presented grade 2 lymphopenia after RT and another (with baseline grade 3) worsened to grade 4. Overall, the median number of days of hospitalization was 59 (range, 26-151). After RT the median number of days in the hospital was 13 (range, 4-77). With a median follow-up after RT of 112 days (range, 105-150), 7 patients were discharged and 2 patients died, 1 due to sepsis and the other with severe baseline chronic obstructive pulmonary disease from COVID-19 pneumonia. Conclusions: Our preliminary results show that LD-RT was a feasible and well-tolerated treatment, with potential clinical improvement. Randomized trials are needed to establish whether LD-RT improves severe pneumonia.
dc.description.departmentDepto. de Radiología, Rehabilitación y Fisioterapia
dc.description.facultyFac. de Medicina
dc.description.facultyUniversidad Complutense de Madrid
dc.description.refereedTRUE
dc.description.statuspub
dc.identifier.citationSanmamed N, Alcantara P, Cerezo E, Gaztañaga M, Cabello N, Gómez S, Bustos A, Doval A, Corona J, Rodriguez G, Duffort M, Ortuño F, de Castro J, Fuentes ME, Sanz A, López A, Vazquez M. Low-Dose Radiation Therapy in the Management of Coronavirus Disease 2019 (COVID-19) Pneumonia (LOWRAD-Cov19): Preliminary Report. Int J Radiat Oncol Biol Phys. 2021 Mar 15;109(4):880-885. doi: 10.1016/j.ijrobp.2020.11.049. Epub 2020 Nov 26. PMID: 33249142; PMCID: PMC7690272.
dc.identifier.doi10.1016/j.ijrobp.2020.11.049
dc.identifier.issn0360-3016
dc.identifier.officialurlhttp://europepmc.org/abstract/med/33249142
dc.identifier.pmid33249142
dc.identifier.relatedurlhttps://pubmed.ncbi.nlm.nih.gov/33249142/
dc.identifier.urihttps://hdl.handle.net/20.500.14352/100480
dc.issue.number4
dc.journal.titleInternational journal of radiation oncology, biology, physics
dc.language.isoeng
dc.page.final885
dc.page.initial880
dc.publisherElsevier
dc.rights.accessRightsrestricted access
dc.subject.ucmCiencias Biomédicas
dc.subject.unesco32 Ciencias Médicas
dc.titleLow-Dose Radiation Therapy in the Management of Coronavirus Disease 2019 (COVID-19) Pneumonia (LOWRAD-Cov19): Preliminary Report
dc.typejournal article
dc.type.hasVersionAM
dc.volume.number109
dspace.entity.typePublication
relation.isAuthorOfPublicationd57a2409-23f5-41af-b8b9-680c861e9502
relation.isAuthorOfPublicatione55c3b8b-7774-44dc-b0c1-b87e1b197ee1
relation.isAuthorOfPublicationac0d98c9-7d90-45f4-859e-09aad38abc58
relation.isAuthorOfPublicationbe5af101-c734-49a5-87dc-8396a4907a99
relation.isAuthorOfPublication710a1eb1-0353-4931-98a3-86081b4467d3
relation.isAuthorOfPublicationc663af30-271f-47da-a521-7d5c16e943f0
relation.isAuthorOfPublicationeb2f75d1-bb29-4ff3-a44c-670139ea0b5a
relation.isAuthorOfPublication89e36473-aaf6-4120-b44e-f77b35604283
relation.isAuthorOfPublication.latestForDiscoveryd57a2409-23f5-41af-b8b9-680c861e9502
Download
Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Low-Dose Radiation Therapy in the Management of Coronavirus Disease 2019 (COVID-19) Pneumonia (LOWRAD-Cov19) Preliminary Report.pdf
Size:
776.35 KB
Format:
Adobe Portable Document Format
Download
Collections
Artículos