Characterization of a novel murine model of Toxoplasma gondii infection using oocysts of a recently obtained Type III isolate

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dc.contributor.authorLargo de la Torre, Andrea
dc.contributor.authorFerré Pérez, Ignacio
dc.contributor.authorSánchez Sánchez, Roberto
dc.contributor.authorRegidor Cerrillo, Javier
dc.contributor.authorOrtega Mora, Luis Miguel
dc.date.accessioned2025-05-14T14:54:08Z
dc.date.available2025-05-14T14:54:08Z
dc.date.issued2025-04-02
dc.descriptionContributions: LMOM, JRC and IF conceived the study and participated in its design. RSS carried out the oocyst production and, together with ALT, participated in the inoculation of animals. ALT conducted the clinical examination of animals, performed necropsies and collected samples. JRC and ALT analyzed the data, carried out statistical analyses and interpreted the results. ALT and JRC wrote the manuscript with result interpretation and inputs from LMOM and I.F. All authors read and approved the final manuscript.
dc.description.abstractType II reference isolates of Toxoplasma gondii are widely used in animal toxoplasmosis models, but studies with Type III isolates remain scarce. In addition, these methods often rely on laboratory-adapted parasite stages that may not reflect natural infection. This study presents a new murine model based on an oral infection with oocysts from a recently obtained Type III isolate, TgShSp24, which exhibited remarkable morbidity and a distinct tissue distribution during chronic infection, differing from the recently obtained Type II isolate TgShSp1. This novel model aims to better mimic natural infection and provides a valuable tool for testing drugs and vaccines.
dc.description.departmentDepto. de Sanidad Animal
dc.description.facultyFac. de Veterinaria
dc.description.refereedTRUE
dc.description.sponsorshipComunidad de Madrid
dc.description.sponsorshipMinisterio de Ciencia e Innovación (España)
dc.description.statuspub
dc.identifier.citationLargo-de la Torre, A., Ferre, I., Sánchez-Sánchez, R., Regidor-Cerrillo, J., Ortega-Mora, L.M (2025) Characterization of a novel murine model of Toxoplasma gondii infection using oocysts of a recently obtained Type III isolate. Vet Res 56, 73. https://doi.org/10.1186/s13567-025-01507-x
dc.identifier.doi10.1186/s13567-025-01507-x
dc.identifier.essn1297-9716
dc.identifier.issn0928-4249
dc.identifier.officialurlhttps://doi.org/10.1186/s13567-025-01507-x
dc.identifier.urihttps://hdl.handle.net/20.500.14352/120104
dc.issue.number73
dc.journal.titleVeterinary Research
dc.language.isoeng
dc.page.final7
dc.page.initial1
dc.publisherSpringer
dc.relation.projectIDS-2019/L2-386
dc.relation.projectIDDIN2020-011454/AEI/https://doi.org/10.13039/501100011033
dc.rightsAttribution 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.cdu636.09
dc.subject.keywordToxoplasma gondii
dc.subject.keywordMouse model
dc.subject.keywordOocyst
dc.subject.keywordType II and Type III
dc.subject.keywordFeld isolate
dc.subject.ucmVeterinaria
dc.subject.unesco3109 Ciencias Veterinarias
dc.titleCharacterization of a novel murine model of Toxoplasma gondii infection using oocysts of a recently obtained Type III isolate
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number56
dspace.entity.typePublication
relation.isAuthorOfPublicationee049535-46a4-469e-a863-26a74c7c22ef
relation.isAuthorOfPublication2eb795e6-6289-414d-904a-2699a570b874
relation.isAuthorOfPublication999bdff5-8f14-4d4b-9b18-ba75a422c772
relation.isAuthorOfPublication.latestForDiscoveryee049535-46a4-469e-a863-26a74c7c22ef

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