Assessment of diagnostic tools for eradication of bovine tuberculosis in cattle co-infected with Mycobacterium bovis and M. avium subsp. paratuberculosis

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dc.contributor.authorAranaz Martín, Alicia
dc.contributor.authorJuan Ferré, Lucía De
dc.contributor.authorBezos Garrido, Javier
dc.contributor.authorÁlvarez Sánchez, Julio
dc.contributor.authorRomero Martínez, Beatriz
dc.contributor.authorLozano, Francisco
dc.contributor.authorParamio, José L.
dc.contributor.authorLópez-Sánchez, Jesús
dc.contributor.authorMateos García, Ana Isabel
dc.contributor.authorDomínguez Rodríguez, Lucas José
dc.date.accessioned2024-01-17T13:06:22Z
dc.date.available2024-01-17T13:06:22Z
dc.date.issued2006-05-16
dc.descriptionCorresponding author: Alicia Aranaz alaranaz@vet.ucm.es; Free access;
dc.description.abstractThe intradermal tuberculin (IDTB) test and the interferon-gamma (IFN-$\gamma$) assay are used worldwide for detection of bovine tuberculosis in cattle, but little is known about the effect of co-infecting agents on the performance of these diagnostic tests. This report describes a field trial conducted in a cattle herd with dual infection (bovine tuberculosis and paratuberculosis) during 3.5 years. It has been based on a strategic approach encompassing serial parallel testing (comparative IDTB test, the IFN-$\gamma$ assay and serology of paratuberculosis) that was repeated 8 times over the period, and segregation of animals into two herds. The IDTB test detected 65.2% and the IFN-$\gamma$ test detected 69.6% of the Mycobacterium bovis culture-positive cattle. However, the IDTB test performed better during the first part of the trial, while the IFN-$\gamma$ test was the only method that detected infected animals during the following three samplings. The number of false positive reactors with the IDTB and/or the IFN-$\gamma$ tests was remarkably high compared to other reports, and could be caused by cross-reactivity with M. avium subsp. paratuberculosis. Also, the M. bovis isolates from cattle and wildlife from the same property were characterised using molecular techniques to disclose an epidemiological link. The IDTB test may not be appropriate to eradicate bovine tuberculosis in herds with dual mycobacterial infections. This report highlights the need to use several diagnostic techniques for the accurate detection of M. bovis infected animals in these herds.
dc.description.departmentDepto. de Sanidad Animal
dc.description.facultyFac. de Veterinaria
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Ciencia y Tecnología
dc.description.sponsorshipMinisterio de Agricultura, Pesca y Alimentación
dc.description.statuspub
dc.identifier.citationAranaz, A., De Juan, L., Bezos, J., Alvarez, J., Romero, B., Lozano, F., Paramio, J. L., López-Sánchez, J., Mateos, A., & Domínguez, L. (2006). Assessment of diagnostic tools for eradication of bovine tuberculosis in cattle co-infected with Mycobacterium bovis and M. avium subsp. paratuberculosis. Veterinary research, 37(4), 593–606. https://doi.org/10.1051/vetres:2006021
dc.identifier.doi10.1051/vetres:2006021
dc.identifier.essn1297-9716
dc.identifier.issn0928-4249
dc.identifier.officialurlhttps://www.vetres.org/articles/vetres/abs/2006/04/v6038/v6038.html
dc.identifier.urihttps://hdl.handle.net/20.500.14352/93610
dc.issue.number4
dc.journal.titleVeterinary Research
dc.language.isoeng
dc.page.final606
dc.page.initial593
dc.publisherBMC
dc.rightsAttribution 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.keywordTuberculosis
dc.subject.keywordParatuberculosis
dc.subject.keywordIDTB
dc.subject.keywordIFN-γ
dc.subject.keywordEradication
dc.subject.ucmVeterinaria
dc.subject.unesco3109 Ciencias Veterinarias
dc.titleAssessment of diagnostic tools for eradication of bovine tuberculosis in cattle co-infected with Mycobacterium bovis and M. avium subsp. paratuberculosis
dc.typejournal article
dc.type.hasVersionAM
dc.volume.number37
dspace.entity.typePublication
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