Both HCV Infection and Elevated Liver Stiffness Significantly Impacts on Several Parameters of T-Cells Homeostasis in HIV-Infected Patients

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dc.contributor.authorRestrepo, Clara
dc.contributor.authorÁlvarez, Beatriz
dc.contributor.authorValencia Delfa, José Luis
dc.contributor.authorGarcía, Marcial
dc.contributor.authorNavarrete Muñoz, María A.
dc.contributor.authorLigos, José M.
dc.contributor.authorCabello, Alfonso
dc.contributor.authorPrieto, Laura
dc.contributor.authorNistal, Sara
dc.contributor.authorMontoya, María
dc.contributor.authorGórgolas, Miguel
dc.contributor.authorRallón, Norma
dc.contributor.authorBenito, José M.
dc.date.accessioned2023-06-17T09:11:31Z
dc.date.available2023-06-17T09:11:31Z
dc.date.issued2020-09-15
dc.description.abstract1) Background: The role of hepatitis C virus (HCV) co-infection on the T-cell homeostasis disturbances in human immunodeficiency virus (HIV)-infected patients as well as its reversion after HCV eradication with direct acting antivirals (DAAs) therapy has not been yet clarified. We extensively analyzed the effect of HCV co-infection on immune parameters of HIV pathogenesis and its evolution after HCV eradication with DAAs. (2) Methods: Seventy individuals were included in the study—25 HIV-monoinfected patients, 25 HIV/HCV-coinfected patients and 20 HIV and HCV seronegative subjects. All patients were on antiretroviral therapy and undetectable HIV-viremia. Immune parameters, such as maturation, activation, apoptosis, senescence and exhaustion of T-cells were assessed by flow cytometry. Cross-sectional and longitudinal (comparing pre- and post-DAAs data in HIV/HCV coinfected patients) analyses were performed. Univariate and multivariate (general linear model and canonical discriminant analysis -CDA-) analyses were used to assess differences between groups. (3) Results—The CDA was able to clearly separate HIV/HCV coinfected from HIV-monoinfected patients, showing a more disturbed T-cells homeostasis in HIV/HCV patients, especially activation and exhaustion of T-cells. Interestingly, those perturbations were more marked in HIV/HCV patients with increased liver stiffness. Eradication of HCV with DAAs restored some but not all the T-cells homeostasis disturbances, with activation and exhaustion of effector CD8 T-cells remaining significantly increased three months after HCV eradication. (4) Conclusions—HCV co-infection significantly impacts on several immune markers of HIV pathogenesis, especially in patients with increased liver stiffness. Eradication of HCV with DAAs ameliorates but does not completely normalize these alterations. It is of utmost relevance to explore other mechanisms underlying the immune damage observed in HIV/HCV coinfected patients with control of both HIV and HCV replication.
dc.description.departmentDepto. de Estadística y Ciencia de los Datos
dc.description.facultyFac. de Estudios Estadísticos
dc.description.refereedTRUE
dc.description.sponsorshipInstituto de Salud Carlos III (ISCIII)/FEDER
dc.description.sponsorshipCentro de Excelencia Severo Ochoa
dc.description.sponsorshipInstituto de Salud Carlos III (ISCIII)
dc.description.sponsorshipComunidad de Madrid
dc.description.sponsorshipFundación Jímenez Díaz
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/67521
dc.identifier.doi10.3390/jcm9092978
dc.identifier.issn2077-0383
dc.identifier.officialurlhttps://doi.org/10.3390/jcm9092978
dc.identifier.relatedurlhttps://www.mdpi.com/2077-0383/9/9/2978
dc.identifier.urihttps://hdl.handle.net/20.500.14352/8364
dc.issue.number9
dc.journal.titleJournal of Clinical Medicine
dc.language.isoeng
dc.page.initial2978
dc.publisherMDPI
dc.relation.projectIDPI14/00518 and RD16/0025/0013
dc.relation.projectIDSEV-2015-0505
dc.relation.projectIDCPII19/00025
dc.relation.projectIDIND2018/BMD-9651.
dc.relation.projectIDRD16/0025/0013
dc.rightsAtribución 3.0 España
dc.rights.accessRightsopen access
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/es/
dc.subject.keywordHIV/HCV coinfection
dc.subject.keywordT-cell homeostasis disturbances
dc.subject.keywordliver stiffness
dc.subject.keywordimmune restoration
dc.subject.keywordDAAs-based therapy
dc.subject.ucmEnfermedades infecciosas
dc.subject.ucmGastroenterología y hepatología
dc.subject.ucmInmunología
dc.subject.unesco3205.05 Enfermedades Infecciosas
dc.subject.unesco3205.03 Gastroenterología
dc.subject.unesco2412 Inmunología
dc.titleBoth HCV Infection and Elevated Liver Stiffness Significantly Impacts on Several Parameters of T-Cells Homeostasis in HIV-Infected Patients
dc.typejournal article
dc.volume.number9
dspace.entity.typePublication
relation.isAuthorOfPublication153a1548-7c75-437a-b6e7-366c2447bd9e
relation.isAuthorOfPublication.latestForDiscovery153a1548-7c75-437a-b6e7-366c2447bd9e
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