Aviso: para depositar documentos, por favor, inicia sesión e identifícate con tu cuenta de correo institucional de la UCM con el botón MI CUENTA UCM. No emplees la opción AUTENTICACIÓN CON CONTRASEÑA
 

ITH12410/SC058: A New Neuroprotective Compound with Potential in the Treatment of Alzheimer’s Disease

Simple item page
dc.contributor.authorRomero Martínez, Manuel Alejandro
dc.contributor.authorEgea, Javier
dc.contributor.authorGonzález-Muñoz, Gema
dc.contributor.authorMartín De Saavedra Álvarez De Uribarri, María Dolores
dc.contributor.authorBarrio, Laura del
dc.contributor.authorRodríguez-Franco, María Isabel
dc.contributor.authorConde, Santiago
dc.contributor.authorLópez, Manuela
dc.contributor.authorVillarroya, Mercedes
dc.contributor.authorRíos, Cristóbal de los
dc.date.accessioned2024-01-31T09:10:13Z
dc.date.available2024-01-31T09:10:13Z
dc.date.issued2014
dc.description.abstractThe neuroprotective profile of the dibenzothiadiazepine ITH12410/SC058 (2-chloro-5,6-dihydro-5,6-diacetyldibenzo[b,f][1,4,5]thiadiazepine) against several neurotoxicity models related to neurodegenerative diseases is herein described. ITH12410/SC058 protected SH-SY5Y cells against the loss of cell viability elicited by amyloid beta peptide and okadaic acid, a selective inhibitor of phosphoprotein phosphatase 2A that induces neurofibrillary tangle formation. Furthermore, ITH12410/SC058 is neuroprotective against several in vitro models of oxidative stress, that is, H2O2 exposure or incubation with rotenone plus oligomycin A in SH-SY5Y cells, and oxygen and glucose deprivation followed by reoxygenation in rat hippocampal slices. By contrast, ITH12410/SC058 was unable to significantly protect SH-SY5Y neuroblastoma cells against the toxicity elicited by Ca2+ overload. Our results confirm the hypothesis that the dibenzothiadiazepine ITH12410/SC058 features its neuroprotective actions in a multitarget fashion, and is a promising drug for the treatment of neurodegenerative diseaseseng
dc.description.departmentDepto. de Bioquímica y Biología Molecular
dc.description.facultyFac. de Farmacia
dc.description.refereedFALSE
dc.description.sponsorshipInstituto de Salud Carlos III
dc.description.sponsorshipMinisterio de Ciencia, Innovación y Universidades (España)
dc.description.sponsorshipMinisterio de Economía, Comercio y Empresa (España)
dc.description.statuspub
dc.identifier.doi10.1021/cn500131t
dc.identifier.issn1948-7193
dc.identifier.officialurlhttps://doi.org/10.1021/cn500131t
dc.identifier.relatedurlhttps://pubs.acs.org/doi/10.1021/cn500131t
dc.identifier.urihttps://hdl.handle.net/20.500.14352/96908
dc.issue.number9
dc.language.isoeng
dc.page.final866
dc.page.initial745
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/PI13/0078
dc.relation.projectIDinfo:eu-repo/grantAgreement/SAF2009-12150
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/SAF2012-31035
dc.rights.accessRightsrestricted access
dc.subject.keywordDibenzothiadiazepine
dc.subject.keywordNeurodegenerative diseases
dc.subject.keywordOxidative stress
dc.subject.keywordAlzheimer’s disease
dc.subject.keywordAmyloid beta
dc.subject.keywordNeurofibrillary tangles
dc.subject.keywordNeuroprotective drugs
dc.subject.ucmCiencias Biomédicas
dc.subject.unesco24 Ciencias de la Vida
dc.titleITH12410/SC058: A New Neuroprotective Compound with Potential in the Treatment of Alzheimer’s Disease
dc.typejournal article
dc.volume.number5
dspace.entity.typePublication
relation.isAuthorOfPublicationc658be58-bda9-4100-ad65-bac31e1256af
relation.isAuthorOfPublicationfbe82c93-5eab-40fa-b3f0-66c65e8e6e5d
relation.isAuthorOfPublication.latestForDiscoveryfbe82c93-5eab-40fa-b3f0-66c65e8e6e5d

Download

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
ith12410-sc058.pdf
Size:
412.62 KB
Format:
Adobe Portable Document Format
Download

Collections

Artículos