Decreased oxytocin plasma levels and oxytocin receptor expression in borderline personality disorder

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dc.contributor.authorBuenache, E.
dc.contributor.authorDe la Vega, I.
dc.contributor.authorLópez‐Villatoro, J. M.
dc.contributor.authorMoreno Moreno, Beatriz
dc.contributor.authorCarrasco Perera, José Luis
dc.contributor.authorMac-Dowell Mata, Karina Soledad
dc.contributor.authorDíaz Marsa, Marina Francisca
dc.contributor.authorLeza Cerro, Juan Carlos
dc.date.accessioned2024-01-30T19:17:20Z
dc.date.available2024-01-30T19:17:20Z
dc.date.issued2020-08-12
dc.description.abstractIntroduction: Borderline personality disorder (BPD) is characterized by intense affective reactions with underlying social and interpersonal cognitive deficits. Oxytocin has largely been associated with both stress regulation and social cognition in psychiatric patients and in non-clinical populations in previous studies. Finally, abnormal oxytocin levels have been preliminary reported in BPD patients. Methods: 53 patients with moderate-severe BPD and 31 healthy control subjects were investigated for plasma levels of oxytocin and protein expression of oxytocin receptor in blood mononuclear cells. Clinical assessments were made for severity, functionality, and comorbidity with axis I and II conditions. Results: Oxytocin plasma levels were significantly lower in BPD patients compared with controls. In addition, protein expression of oxytocin receptor was significantly reduced in the BPD group. A positive correlation was found between plasma oxytocin levels and the activity index score of the Zuckerman-Kuhlman Personality Questionnaire (ZKPQ). Oxytocin receptor protein expression, on the contrary, had a negative correlation with the ZKPQ sociability index score. Conclusions: Results support the evidence of a dysfunction of the oxytocin system in borderline personality disorder, which could be involved in emotional dysregulation and interpersonal disturbances in these patients.
dc.description.departmentDepto. de Farmacología y Toxicología
dc.description.departmentDepto. de Medicina Legal, Psiquiatría y Patología
dc.description.facultyFac. de Medicina
dc.description.refereedTRUE
dc.description.sponsorshipInstituto de Salud Carlos III
dc.description.sponsorshipFEDER
dc.description.statuspub
dc.identifier.citationCarrasco JL, Buenache E, MacDowell KS, De la Vega I, López-Villatoro JM, Moreno B, Díaz-Marsá M, Leza JC. Decreased oxytocin plasma levels and oxytocin receptor expression in borderline personality disorder. Acta Psychiatr Scand. 2020 Oct;142(4):319-325. doi: 10.1111/acps.13222. PMID: 32740913.
dc.identifier.doi10.1111/acps.13222
dc.identifier.issn0001-690X
dc.identifier.issn1600-0447
dc.identifier.officialurlhttps://onlinelibrary.wiley.com/doi/10.1111/acps.13222
dc.identifier.relatedurlhttps://pubmed.ncbi.nlm.nih.gov/32740913/
dc.identifier.urihttps://hdl.handle.net/20.500.14352/96800
dc.issue.number4
dc.journal.titleActa Psychiatrica Scandinavica
dc.language.isoeng
dc.page.final325
dc.page.initial319
dc.publisherWiley
dc.relation.projectIDPI17/01023
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.cdu616.89
dc.subject.cdu616.89-007
dc.subject.cdu612.8
dc.subject.keywordBorderline personality disorder
dc.subject.keywordImpulsivity
dc.subject.keywordOxytocin
dc.subject.keywordSocial dysregulation
dc.subject.ucmCiencias Biomédicas
dc.subject.unesco24 Ciencias de la Vida
dc.titleDecreased oxytocin plasma levels and oxytocin receptor expression in borderline personality disorder
dc.typejournal article
dc.type.hasVersionAM
dc.volume.number142
dspace.entity.typePublication
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relation.isAuthorOfPublicationd7de3e71-d141-4e63-ab4c-a71249846532
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relation.isAuthorOfPublication.latestForDiscovery2e67aac9-a0a6-4ec3-9710-589be1cf5877
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