Detection of major food allergens in amniotic fluid: initial allergenic encounter during pregnancy

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dc.contributor.authorPastor Vargas, Carlos
dc.contributor.authorAroa S. Maroto
dc.contributor.authorAraceli Díaz‐Perales
dc.contributor.authorVillalba Díaz, María Teresa
dc.contributor.authorVanesa Esteban
dc.contributor.authorMarta Ruiz‐Ramos
dc.contributor.authorMarta Rodriguez de Alba
dc.contributor.authorVivanco Martínez, Fernando
dc.contributor.authorJavier Cuesta‐Herranz
dc.date.accessioned2024-07-22T07:45:32Z
dc.date.available2024-07-22T07:45:32Z
dc.date.issued2016-07-29
dc.description.abstractBackground: Ingestion of food allergens present in maternal milk during breastfeeding has been hypothesized as a gateway to sensitization to food; however, this process could develop during pregnancy, as the maternal-fetal interface develops a Th2- and Treg-mediated environment to protect the fetus. We hypothesized that in these surroundings, unborn children are exposed to food allergens contained in the mother's diet, possibly giving rise to first sensitization. Methods: The presence of allergens in utero was studied by analyzing amniotic fluid (AF) samples in two different stages of pregnancy: at 15-20 weeks and after delivery at term. An antibody microarray was developed to test for the most common food allergens. The array detects the presence of ten allergens from milk, fruit, egg, fish, nuts, and wheat. Results: AF from 20 pregnant women was collected: eight after delivery at term and 12 from women who underwent diagnostic amniocentesis between weeks 15 and 20 of gestation. The presence of allergens was detected in all samples. Samples from amniocentesis had a higher allergen concentration than samples after delivery at term. Conclusions: We demonstrated the presence of intact major food allergens in AF samples. This early contact could explain subsequent sensitization to foods never eaten before.
dc.description.departmentDepto. de Bioquímica y Biología Molecular
dc.description.facultyFac. de Ciencias Químicas
dc.description.fundingtypePagado por el autor
dc.description.refereedTRUE
dc.description.statuspub
dc.identifier.citationPastor-Vargas C, Maroto AS, Díaz-Perales A, Villalba M, Esteban V, Ruiz-Ramos M, de Alba MR, Vivanco F, Cuesta-Herranz J. Detection of major food allergens in amniotic fluid: initial allergenic encounter during pregnancy. Pediatr Allergy Immunol. 2016 Nov;27(7):716-720. doi: 10.1111/pai.12608. Epub 2016 Jul 29. PMID: 27341427.
dc.identifier.doi10.1111/pai.12608
dc.identifier.issn0905-6157
dc.identifier.issn1399-3038
dc.identifier.officialurlhttps://doi.org/10.1111/pai.12608
dc.identifier.relatedurlhttps://onlinelibrary.wiley.com/doi/full/10.1111/pai.12608
dc.identifier.urihttps://hdl.handle.net/20.500.14352/106950
dc.issue.number7
dc.journal.titlePediatr Allergy Immunol
dc.language.isoeng
dc.page.final720
dc.page.initial716
dc.publisherWiley
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.cdu616-056.3
dc.subject.keywordAmniotic fluid
dc.subject.keywordAntibody array
dc.subject.keywordFood allergens
dc.subject.keywordFood allergy
dc.subject.ucmAlergología
dc.subject.ucmAlergología
dc.subject.unesco32 Ciencias Médicas
dc.subject.unesco3207.01 Alergias
dc.titleDetection of major food allergens in amniotic fluid: initial allergenic encounter during pregnancy
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number27
dspace.entity.typePublication
relation.isAuthorOfPublication25af78c7-0077-4891-a14e-bcd8e51fe408
relation.isAuthorOfPublication8538de4d-b88e-451c-b981-64bcc0bfeede
relation.isAuthorOfPublication6f3e7679-cbc7-4f23-8355-2de0876d46ad
relation.isAuthorOfPublication.latestForDiscovery25af78c7-0077-4891-a14e-bcd8e51fe408
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