Publication:
The heartbeat evoked potential is a questionable biomarker in nightmare disorder: A replication study

dc.contributor.authorBogdány, Tamás
dc.contributor.authorPerakakis, Pandelis
dc.contributor.authorBódizs, Róbert
dc.contributor.authorSimor, Péter
dc.date.accessioned2023-06-22T10:47:21Z
dc.date.available2023-06-22T10:47:21Z
dc.date.issued2022-12-31
dc.description.abstractFrequent nightmares are highly prevalent and constitute a risk factor for a wide range of psychopathological conditions. Despite its prevalence and clinical relevance however, the pathophysiological mechanisms of nightmares are poorly understood. A recent study (Perogamvros et, al 2019) examined the heart beat evoked potential (HEP) in a small group of nightmare sufferers (N = 11) and matched healthy controls (N = 11) and observed markedly different (Hedges’ g = 1.42 [0.62–2.22]) HEP response across the groups during Rapid Eye Movement (REM) sleep. Moreover, the HEP correlated with depression scores in the nightmare group only. The authors concluded that the HEP in REM sleep could be used as a trait-like biomarker reflecting pathological emotional-and sleep regulation in nightmare disorder. To replicate the above study, we performed the same analyses of HEPs in two separate, and larger databases comprising the polysomnographic recordings of nightmare sufferers and matched controls (N Study 1 =39 ; N Study 2 =41). In contrast to the original findings, we did not observe significant differences in HEP across the two groups in either of the two databases. Moreover, we found no associations between depression scores and HEP amplitudes in the relevant spatiotemporal cluster. Our data cast doubts on the utility of HEP as a biomarker in the diagnostic and treatment procedures of nightmare disorder and suggests that the interpretation of HEP as a marker of impaired arousal and emotional processing during REM sleep is premature and requires further validation.
dc.description.departmentDepto. de Psicología Social, del Trabajo y Diferencial
dc.description.facultyFac. de Psicología
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Ciencia e Innovación (MICINN)
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/72982
dc.identifier.doi10.1016/j.nicl.2021.102933
dc.identifier.issn2213-1582
dc.identifier.officialurlhttps://doi.org/10.1016/j.nicl.2021.102933
dc.identifier.urihttps://hdl.handle.net/20.500.14352/71668
dc.journal.titleNeuroimage: clinical
dc.language.isoeng
dc.publisherElsevier
dc.relation.projectIDPGC2018-096655-A-I00
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España
dc.rights.accessRightsopen access
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subject.keywordNightmare
dc.subject.keywordHeartbeat evoked potential
dc.subject.keywordSleep
dc.subject.keywordREM
dc.subject.keywordReplication
dc.subject.ucmNeuropsicología
dc.titleThe heartbeat evoked potential is a questionable biomarker in nightmare disorder: A replication study
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number33
dspace.entity.typePublication
Files
Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
Bogdany_2022.pdf
Size:
1.27 MB
Format:
Adobe Portable Document Format
Collections