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Nanoparticles for Multimodal Antivascular Therapeutics: Dual Drug Release, Photothermal and Photodynamic Therapy.

dc.contributor.authorParis, J. L.
dc.contributor.authorVillaverde Cantizano, Gonzalo
dc.contributor.authorGómez Graña, Sergio
dc.contributor.authorVallet Regí, María Dulce Nombre
dc.date.accessioned2023-06-16T15:15:23Z
dc.date.available2023-06-16T15:15:23Z
dc.date.issued2019-11-06
dc.descriptionRESEARCHER ID D-9318-2017 (Juan Luis Paris de la Fuente) ORCID 0000-0001-8950-283X (Juan Luis Paris de la Fuente) RESEARCHER ID L-2250-2014 (Gonzalo Villaverde Cantizano) ORCID 0000-0003-2065-0417 (Gonzalo Villaverde Cantizano) RESEARCHER ID G-7562-2016 (Sergio Gómez Graña) ORCID 0000-0002-7736-051X (Sergio Gómez Graña) RESEARCHER ID M-3378-2014 (María Vallet Regí) ORCID 0000-0002-6104-4889 (María Vallet Regí)
dc.description.abstractThe poor delivery of nanoparticles to target cancer cells hinders their success in the clinical setting. In this work, an alternative target readily available for circulating nanoparticles has been selected to eliminate the need for nanoparticle penetration in the tissue: the tumor blood vessels. A tumor endothelium-targeted nanoparticle (employing an RGD-containing peptide) capable of co-delivering two anti-vascular drugs (one anti-angiogenic drug and one vascular disruption agent) is here presented. Furthermore, the nanodevice presents two additional anti-vascular capabilities upon activation by Near-Infrared light: provoking local hyperthermia (by gold nanorods in the system) and generating toxic reactive oxygen species (by the presence of a photosensitizer). RGD-targeting is shown to increase uptake by HUVEC cells, and while the nanoparticles are shown not to be toxic for these cells, upon Near-Infrared irradiation their almost complete killing is achieved. The combination of all four therapeutic modalities is then evaluated in an ex ovo fibrosarcoma xenograft model, which shows a significant reduction in the number of blood vessels irrigating the xenografts when the nanoparticles are present, as well as the destruction of the existing blood vessels upon irradiation. These results suggest that the combination of different anti-vascular therapeutic strategies in a single nanocarrier appears promising and should be further explored in the future.en
dc.description.departmentDepto. de Química en Ciencias Farmacéuticas
dc.description.facultyFac. de Farmacia
dc.description.refereedTRUE
dc.description.sponsorshipUnión Europea
dc.description.statusinpress
dc.eprint.idhttps://eprints.ucm.es/id/eprint/57826
dc.identifier.citationParis, J. L., Villaverde Cantizano, G., Gómez Graña, S. & Vallet Regí, M. D. N. «Nanoparticles for Multimodal Antivascular Therapeutics: Dual Drug Release, Photothermal and Photodynamic Therapy». Acta Biomaterialia, vol. 101, enero de 2020, pp. 459-68. DOI.org (Crossref), https://doi.org/10.1016/j.actbio.2019.11.004.
dc.identifier.doi10.1016/j.actbio.2019.11.004
dc.identifier.issn1742-7061
dc.identifier.officialurlhttps//doi.org/10.1016/j.actbio.2019.11.004
dc.identifier.relatedurlhttps://www.journals.elsevier.com/acta-biomaterialia
dc.identifier.relatedurlhttp://www.ucm.es/valletregigroup
dc.identifier.urihttps://hdl.handle.net/20.500.14352/5968
dc.journal.titleActa Biomaterialia
dc.language.isoeng
dc.publisherElsevier
dc.relation.projectIDVERDI (694160)
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/Number of agreement
dc.rights.accessRightsopen access
dc.subject.cdu546
dc.subject.cdu615,46
dc.subject.cdu66
dc.subject.keywordNanomedicine
dc.subject.keywordMesoporous Silica Nanoparticles
dc.subject.keywordAnti Vascular
dc.subject.keywordPhotothermal therapy
dc.subject.keywordPhotodynamic therapy.
dc.subject.ucmMateriales
dc.subject.ucmQuímica inorgánica (Farmacia)
dc.subject.unesco3312 Tecnología de Materiales
dc.titleNanoparticles for Multimodal Antivascular Therapeutics: Dual Drug Release, Photothermal and Photodynamic Therapy.en
dc.typejournal article
dspace.entity.typePublication
relation.isAuthorOfPublication13785694-551d-4e51-90ca-f777965d8413
relation.isAuthorOfPublicationd34d9a95-85dd-4071-ab2c-71a22cf3ceae
relation.isAuthorOfPublication791023b8-2531-44eb-ba01-56e3b7caa0cb
relation.isAuthorOfPublication.latestForDiscovery791023b8-2531-44eb-ba01-56e3b7caa0cb

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