Phenotypic and genetic characterization of antimicrobial resistance in <i>Salmonella enterica</i> serovar Choleraesuis isolates from humans and animals in Spain from 2006 to 2021

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dc.contributor.authorCamille Jacqueline
dc.contributor.authorClara Samper-Cativiela
dc.contributor.authorSara Monzon Fernandez
dc.contributor.authorUgarte Ruiz, María
dc.contributor.authorIsabel Cuesta de la Plaza
dc.contributor.authorÁlvarez Sánchez, Julio
dc.contributor.authorSilvia Herrera-Leon
dc.date.accessioned2024-03-19T11:59:06Z
dc.date.available2024-03-19T11:59:06Z
dc.date.issued2024-02-16
dc.description.abstractObjectics: While an increase in the levels of MDR in Salmonella enterica sevorar Choleraesuis has been reported in Europe, little is known about the situation in Spain. Therefore, we first aimed to assess the phenotypic resistance profile and to determine the presence of genetic determinants of resistance of S. Choleraesuis isolates collected in animal and human. Our second objective was to identify and characterize clusters of highly related isolates. Methods: We analysed 50 human and 45 animal isolates retrieved from 2006 to 2021 using the disc diffusion method and performed WGS followed by analyses of genetic determinants and phylogenetic analysis. Results: All isolates were of ST145 and corresponded to the variant Kunzendorf. Swine isolates harboured a significantly higher number of antimicrobial resistance genes than human isolates, and often carried plasmid replicons of the IncHI2/IncHI2A type (42% of all animal isolates). In addition, we identified several MDR S. Choleraesuis strains circulating in humans and swine between 2006 and 2021. The phylogenetic analyses identified four clades associated with specific patterns of resistance genes and plasmid replicons. The clades also included isolates that differed in terms of year and region of isolation as well as host of origin. Conclusions: This One Health approach highlights that reducing human MDR S. Choleraesuis infections may require the adoption of strategies that not only seek to prevent cases in humans but also to characterize and reduce the infection burden in swine.
dc.description.departmentDepto. de Sanidad Animal
dc.description.facultyCentro de Vigilancia Sanitaria Veterinaria (VISAVET)
dc.description.facultyFac. de Veterinaria
dc.description.refereedTRUE
dc.description.sponsorshipEuropean Centre for Disease Prevention and Control (ECDC)
dc.description.sponsorshipMinisterio de Economía y Competitividad
dc.description.statuspub
dc.identifier.citationJacqueline C, Samper-Cativiela C, Monzon S, Ugarte-Ruiz M, Cuesta I, Alvarez J and Herrera-Leon S. Phenotypic and genetic characterization of antimicrobial resistance in Salmonella enterica serovar Choleraesuis isolates from humans and animals in Spain from 2006 to 2021. The Journal of Antimicrobial Chemotherapy, 1-11. 2024. (A). ISSN: 0305-7453. Impact factor 2022: 5.200. Category: Infectious Diseases, Quartile: 2, Position: 29 of 96. DOI: 10.1093/jac/dkae029
dc.identifier.doi10.1093/jac/dkae029
dc.identifier.issn0305-7453
dc.identifier.issn1460-2091
dc.identifier.officialurl10.1093/jac/dkae029
dc.identifier.urihttps://hdl.handle.net/20.500.14352/102339
dc.journal.titleJournal of Antimicrobial Chemotherapy
dc.language.isoeng
dc.publisherOxford University Press
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//IDI-20120422/ES/PLATAFORMA MVC Y MULTISISTEMA PARA GENERACIÓN DE SOLUCIONES PROFESIONALES DE GESTIÓN/
dc.relation.projectIDCT19/20
dc.rightsAttribution 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.cdu636.09
dc.subject.keywordphenotype
dc.subject.keywordplasmids
dc.subject.keywordsalmonella enterica
dc.subject.keywordphylogenetic analysis
dc.subject.keywordresistance genes
dc.subject.keywordwhole genome sequencing
dc.subject.ucmVeterinaria
dc.subject.unesco3109 Ciencias Veterinarias
dc.titlePhenotypic and genetic characterization of antimicrobial resistance in <i>Salmonella enterica</i> serovar Choleraesuis isolates from humans and animals in Spain from 2006 to 2021
dc.typejournal article
dc.type.hasVersionVoR
dspace.entity.typePublication
relation.isAuthorOfPublication1cdbd911-1dfe-4f9c-b9ad-d9c8f03d2956
relation.isAuthorOfPublication7a0cfc93-a3f1-45bf-b529-403f216cf8f7
relation.isAuthorOfPublication.latestForDiscovery1cdbd911-1dfe-4f9c-b9ad-d9c8f03d2956
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Phenotypic and genetic characterization of antimicrobial resistance in Salmonella enterica serovar Choleraesuis isolates from humans and animals in Spain from 2006 to 2021
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