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Enzyme-mediated synthesis of Molnupiravir: paving the way for the application of biocatalysis in pharmaceutical industry

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dc.contributor.authorCruz, Guillermo
dc.contributor.authorAcosta, Javier
dc.contributor.authorDel Arco, Jon
dc.contributor.authorClemente Suarez, Vicente Javier
dc.contributor.authorDeroncele, Víctor
dc.contributor.authorFernández Lucas, Jesús
dc.date.accessioned2024-10-10T17:09:23Z
dc.date.available2024-10-10T17:09:23Z
dc.date.issued2022
dc.description.abstractMolnupiravir (Lagevrio®) is an orally-administered anti-COVID-19 agent. Due to the urgency to meet the worldwide demand and the growing environmental concern, there is a need for speed in the industrial implementation of novel and efficient bioprocesses for Molnupiravir synthesis. This concept paper aims to review the most relevant milestones that have guided important developments in the enzyme-mediated synthesis of Molnupiravir, including detailed comments on the advantages and drawbacks of the different synthetic routes. Finally, based on a personal perspective, new greener processes for Molnupiravir manufacturing are proposed and discussed.
dc.description.departmentDepto. de Bioquímica y Biología Molecular
dc.description.facultyFac. de Ciencias Biológicas
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Ciencia e Innovación (España)
dc.description.sponsorshipFundación Banco Santander
dc.description.statuspub
dc.identifier.citationCruz, Guillermo, et al. «Enzyme‐mediated Synthesis of Molnupiravir: Paving the Way for the Application of Biocatalysis in Pharmaceutical Industry». ChemCatChem, vol. 14, n.o 13, julio de 2022, p. e202200140. DOI.org (Crossref), https://doi.org/10.1002/cctc.202200140.
dc.identifier.doi10.1002/cctc.202200140
dc.identifier.essn1867-3899
dc.identifier.issn1867-3880
dc.identifier.officialurlhttps://doi.org/10.1002/cctc.202200140
dc.identifier.relatedurlhttps://chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.1002/cctc.202200140
dc.identifier.urihttps://hdl.handle.net/20.500.14352/108868
dc.issue.number13
dc.journal.titleChemCatChem
dc.language.isoeng
dc.page.final6
dc.page.initial1
dc.publisherWiley-VCH
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-117025RB-I00/ES/BÚSQUEDA Y MEJORA DE 2DESOXIRRIBOSIL TRANSFERASAS MEDIANTE MÉTODOS DE ULTRAALTO RENDIMIENTO PARA LA SÍNTESIS SOSTENIBLE DE NUEVOS ANÁLOGOS DE NUCLEÓSIDO TERAPÉUTICOS/
dc.relation.projectIDinfo:eu-repo/grantAgreement/Fundación Santander//XSAN192006/ES
dc.rightsAttribution-NonCommercial 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subject.cdu577.15
dc.subject.cdu578.1
dc.subject.cdu60
dc.subject.cdu615.281.8
dc.subject.cdu661.12
dc.subject.keywordMolnupiravir
dc.subject.keyword(Chemo)enzymatic processes
dc.subject.keywordEcofriendly
dc.subject.keywordIndustrial scale-u
dc.subject.ucmBioquímica (Biología)
dc.subject.ucmBiología molecular (Biología)
dc.subject.ucmBiotecnología
dc.subject.ucmMedicamentos
dc.subject.ucmQuímica farmaceútica
dc.subject.unesco2403 Bioquímica
dc.subject.unesco2415 Biología Molecular
dc.subject.unesco2420 Virología
dc.subject.unesco2390 Química Farmacéutica
dc.subject.unesco2302.09 Enzimología
dc.subject.unesco3209.08 Preparación de Medicamentos
dc.titleEnzyme-mediated synthesis of Molnupiravir: paving the way for the application of biocatalysis in pharmaceutical industry
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number14
dspace.entity.typePublication
relation.isAuthorOfPublicationf99cf5b4-0f0d-424c-afd9-77bdedffd366
relation.isAuthorOfPublication.latestForDiscoveryf99cf5b4-0f0d-424c-afd9-77bdedffd366

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