Physical activity effects on the individual alpha peak frequency of older adults with and without genetic risk factors for Alzheimer’s Disease: A MEG study

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dc.contributor.authorDe Frutos Lucas, Jaisalmer
dc.contributor.authorLópez Sanz, David
dc.contributor.authorZuluaga Arias, María Del Pilar
dc.contributor.authorRodríguez Rojo, Inmaculada Concepción
dc.contributor.authorCazorla Luna, Raúl
dc.contributor.authorLópez García, María Eugenia
dc.contributor.authorDelgado Losada, María Luisa
dc.contributor.authorMarcos Dolado, Alberto
dc.contributor.authorBarabash Bustelo, Ana
dc.contributor.authorLópez Sánchez, Ramón
dc.contributor.authorMaestu Unturbe, Fernando
dc.contributor.authorFernández Lucas, Alberto Amable
dc.date.accessioned2023-12-21T12:05:36Z
dc.date.available2023-12-21T12:05:36Z
dc.date.issued2018-07-09
dc.description.abstractObjective Since a cure for Alzheimer’s Disease (AD) is yet to be discovered, attention has shifted towards prevention. Physical activity (PA) emerged as a notorious lifestyle factor that could influence brain structure and function. The individual alpha peak frequency (IAPF) is a measure that summarizes the spectral content of brain signals and has been proven to be sensitive to both AD pathology and PA interventions. Therefore, our goal was to unravel whether chronic PA modulates IAPF and if APOE ɛ4 carriage moderates this relationship. Methods We analyzed 4-minutes of resting-state magnetoencephalographic recordings from 100 healthy elders that provided self-reported measures of PA, and the IAPF was calculated. Results We found that IAPF was negatively influenced by age and APOE and positively influenced by PA. The effect of PA on IAPF only remained significant for the ɛ4 non-carriers group. Conclusions PA is positively associated to higher IAPF in healthy older adults and could potentially act as a protective factor against cognitive decline. Nevertheless, such effect is non-significant among elders who are more vulnerable to developing AD due to their genetic carriage. Significance This investigation offers the first neurophysiological evidences on the combined effects of APOE genotype and PA in healthy elders.en
dc.description.departmentDepto. de Medicina Legal, Psiquiatría y Patología
dc.description.facultyFac. de Medicina
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Economía, Comercio y Empresa (España)
dc.description.statuspub
dc.identifier.citationDe Frutos-Lucas, Jaisalmer, et al. «Physical Activity Effects on the Individual Alpha Peak Frequency of Older Adults with and without Genetic Risk Factors for Alzheimer’s Disease: A MEG Study». Clinical Neurophysiology, vol. 129, n.o 9, septiembre de 2018, pp. 1981-89. DOI.org (Crossref), https://doi.org/10.1016/j.clinph.2018.06.026.
dc.identifier.doi10.1016/j.clinph.2018.06.026
dc.identifier.issn1388-2457
dc.identifier.officialurlhttps//doi.org/10.1016/j.clinph.2018.06.026
dc.identifier.relatedurlhttps://www.sciencedirect.com/science/article/pii/S1388245718311507?via%3Dihub
dc.identifier.urihttps://hdl.handle.net/20.500.14352/91700
dc.issue.number9
dc.journal.titleClinical Neurophysiology
dc.language.isoeng
dc.page.final1989
dc.page.initial1981
dc.publisherElsevier
dc.relation.projectIDPSI2012-38375- C03-03
dc.rights.accessRightsembargoed access
dc.subject.keywordAlzheimer’s Disease
dc.subject.keywordAPOE
dc.subject.keywordPhysical Activity
dc.subject.keywordMagnetoencephalography
dc.subject.keywordIndividual Alpha Peak Frequency
dc.subject.keywordAging
dc.subject.ucmCiencias Biomédicas
dc.subject.ucmPsicología experimental
dc.subject.unesco32 Ciencias Médicas
dc.subject.unesco6106.01 Actividad Cerebral
dc.titlePhysical activity effects on the individual alpha peak frequency of older adults with and without genetic risk factors for Alzheimer’s Disease: A MEG studyen
dc.typejournal article
dc.type.hasVersionAM
dc.volume.number129
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