Multivalent Choline Dendrimers as Potent Inhibitors of Pneumococcal Cell-Wall Hydrolysis
| dc.contributor.author | Hernandez-Rocamora, Victor | |
| dc.contributor.author | Maestro García-Donas, María Beatriz | |
| dc.contributor.author | de Waal, Bas | |
| dc.contributor.author | Morales, María | |
| dc.contributor.author | Garcia, Pedro | |
| dc.contributor.author | Meijer, Bert | |
| dc.contributor.author | Merx, Maarten | |
| dc.contributor.author | Sanz, Jesús | |
| dc.date.accessioned | 2024-01-23T15:05:02Z | |
| dc.date.available | 2024-01-16T15:39:57Z | |
| dc.date.available | 2024-01-23T15:05:02Z | |
| dc.date.issued | 2009 | |
| dc.description.abstract | Dendritic cell-wall mimics: Choline-binding proteins from Streptococcus pneumoniae recognize distinctive multivalent choline architectures on the bacterial cell wall. Choline-functionalized dendrimers are potent inhibitors of these essential enzymes, with a 103–104-fold higher affinity than free choline, resulting in inhibition of autolysis and cell separation in bacterial cultures at low micromolar concentrations | |
| dc.description.department | Depto. de Bioquímica y Biología Molecular | |
| dc.description.faculty | Fac. de Ciencias Biológicas | |
| dc.description.refereed | TRUE | |
| dc.description.sponsorship | Escuela Valenciana de Estudios para la Salud | |
| dc.description.sponsorship | Fundación Salvat Inquifarma | |
| dc.description.sponsorship | Ministerio de Educación y Ciencia (España) | |
| dc.description.sponsorship | Instituto de Salud Carlos III | |
| dc.description.sponsorship | Comunidad de Madrid | |
| dc.description.sponsorship | Netherlands Organisation for Scientific Research | |
| dc.description.status | pub | |
| dc.identifier.citation | Hernández‐Rocamora, Víctor M., et al. «Multivalent Choline Dendrimers as Potent Inhibitors of Pneumococcal Cell‐Wall Hydrolysis». Angewandte Chemie International Edition, vol. 48, n.o 5, enero de 2009, pp. 948-51. https://doi.org/10.1002/anie.200803664. | |
| dc.identifier.doi | 10.1002/anie.200803664 | |
| dc.identifier.essn | 1521-3773 | |
| dc.identifier.issn | 1433-7851 | |
| dc.identifier.officialurl | https://doi.org/10.1002/anie.200803664 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14352/93420.2 | |
| dc.issue.number | 5 | |
| dc.journal.title | Angewandte Chemie International Edition | |
| dc.language.iso | eng | |
| dc.page.final | 951 | |
| dc.page.initial | 948 | |
| dc.publisher | Wiley | |
| dc.relation.projectID | (S-BIO-0260/2006) | |
| dc.relation.projectID | (95/2005) | |
| dc.relation.projectID | (700.56.428) | |
| dc.rights | Attribution 4.0 International | en |
| dc.rights.accessRights | open access | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.subject.cdu | 577.1 | |
| dc.subject.ucm | Bioquímica (Química) | |
| dc.subject.unesco | 2403 Bioquímica | |
| dc.title | Multivalent Choline Dendrimers as Potent Inhibitors of Pneumococcal Cell-Wall Hydrolysis | |
| dc.type | journal article | |
| dc.type.hasVersion | AM | |
| dc.volume.number | 48 | |
| dspace.entity.type | Publication | |
| relation.isAuthorOfPublication | 1995e084-52c0-4061-bc50-a5aaeca4ec7a | |
| relation.isAuthorOfPublication.latestForDiscovery | 1995e084-52c0-4061-bc50-a5aaeca4ec7a |
