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Guidelines and considerations for metabolic tolerance tests in mice

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dc.contributor.authorBenede Ubieto, Raquel
dc.contributor.authorEstévez Vázquez, Olga
dc.contributor.authorCubero Palero, Francisco Javier
dc.contributor.authorNevzorova, Yulia
dc.date.accessioned2023-06-16T15:17:48Z
dc.date.available2023-06-16T15:17:48Z
dc.date.issued2020-02-18
dc.description.abstractThe epidemic of the century, Diabetes Mellitus (DM) is continuously rising. Intensive research is urgently needed whereby experimental models represent an essential tool to optimise the diagnostic strategy and to improve therapy. In this review, we describe the central principles of the metabolic tests available in order to study glucose and insulin homeostasis in mice, focusing on the most widely used – the glucose and insulin tolerance tests. We provide detailed experimental procedures as well as the practical implementation of these methods and discuss the main factors that should be taken into account when using this methodology.en
dc.description.departmentDepto. de Genética, Fisiología y Microbiología
dc.description.departmentDepto. de Inmunología, Oftalmología y ORL
dc.description.facultyFac. de Ciencias Biológicas
dc.description.facultyFac. de Medicina
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Economía, Comercio y Empresa (España)
dc.description.sponsorshipComunidad de Madrid
dc.description.sponsorshipUniversidad Complutense de Madrid
dc.description.sponsorshipEuropean Foundation for Alcohol Research
dc.description.sponsorshipGerman Research Foundation
dc.description.sponsorshipEuropean Cooperation in Science and Technology
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/60441
dc.identifier.doi10.2147/DMSO.S234665
dc.identifier.essn1178-7007
dc.identifier.issn1178-7007
dc.identifier.officialurlhttps//doi.org/10.2147/DMSO.S234665
dc.identifier.relatedurlhttps://www.dovepress.com/guidelines-and-considerations-for-metabolic-tolerance-tests-in-mice-peer-reviewed-article-DMSO
dc.identifier.urihttps://hdl.handle.net/20.500.14352/6234
dc.journal.titleDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy
dc.language.isoeng
dc.page.final450
dc.page.initial439
dc.publisherDove Medical Press
dc.relation.projectID(SAF2017-87919R) and (SAF201 6-78711)
dc.relation.projectIDEXOHEP-CM S2017/BMD-3727, NanoLiver-CM Y2018/NMT-4949
dc.relation.projectIDRef. EA 18/14, AMMF 2018/117, Ref. 970935 ¨Liver Pathophysiology¨.
dc.relation.projectIDUCM-25-2019, Ref. 970935 ¨Liver Pathophysiology"
dc.relation.projectIDRef. EA 18/14, AMMF 2018/117
dc.relation.projectIDRYC2015-17438 and RyC2014-15242
dc.relation.projectID(SFB/TRR57/P04, SFB 1382-403224013/A02, DFG NE 2128/2-1)
dc.relation.projectIDCA17112
dc.rightsAtribución-NoComercial 3.0 España
dc.rights.accessRightsopen access
dc.rights.urihttps://creativecommons.org/licenses/by-nc/3.0/es/
dc.subject.cdu577.1
dc.subject.cdu616.4
dc.subject.keywordMetabolic tolerance test
dc.subject.keywordT2DM
dc.subject.keywordObesity
dc.subject.keywordMetabolic syndrome
dc.subject.keywordInsulin resistance
dc.subject.keywordGlucose intolerance
dc.subject.ucmEndocrinología
dc.subject.ucmBioquímica (Biología)
dc.subject.ucmInmunología
dc.subject.ucmGastroenterología y hepatología
dc.subject.unesco3205.02 Endocrinología
dc.subject.unesco2302 Bioquímica
dc.subject.unesco24 Ciencias de la Vida
dc.subject.unesco2412 Inmunología
dc.subject.unesco3206 Ciencias de la Nutrición
dc.titleGuidelines and considerations for metabolic tolerance tests in miceen
dc.typejournal article
dc.volume.number13
dspace.entity.typePublication
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relation.isAuthorOfPublicationfa6eef80-d726-48f3-afbf-85cdfa2036aa
relation.isAuthorOfPublicationb3877679-0fbd-42e6-8541-1efeb2df768a
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relation.isAuthorOfPublication.latestForDiscoveryb3877679-0fbd-42e6-8541-1efeb2df768a

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