C60-based Multivalent Glycoporphyrins Inhibit SARS-CoV-2 Specific Interaction with the DC-SIGN Transmembrane Receptor

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dc.contributor.authorPatino Alonso, Jennifer
dc.contributor.authorCabrera González, Justo Enrique
dc.contributor.authorMerino Gracia, Javier
dc.contributor.authorNieta-Ortiz, Gema
dc.contributor.authorKatati, Jouma
dc.contributor.authorBezerra da Cruz, Carlos
dc.contributor.authorMateos Gil, Pablo
dc.contributor.authorCanales Mayordomo, María Ángeles
dc.contributor.authorLópez Montero, Iván
dc.contributor.authorIllescas Martínez, Beatriz María
dc.contributor.authorDelgado Vázquez, Rafael
dc.contributor.authorMartín León, Nazario
dc.date.accessioned2024-02-02T14:52:07Z
dc.date.available2024-02-02T14:52:07Z
dc.date.issued2023
dc.description.abstractSince WHO has declared the COVID-19 outbreak a global pandemic, nearly seven million deaths have been reported. This efficient spread of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is facilitated by the ability of the spike glycoprotein to bind multiple cell membrane receptors. Although ACE2 is identified as the main receptor for SARS-CoV-2, other receptors could play a role in viral entry. Among others, C-type lectins such as DC-SIGN are identified as efficient trans-receptor for SARS-CoV-2 infection, so the use of glycomimetics to inhibit the infection through the DC-SIGN blockade is an encouraging approach. In this regard, multivalent nanostructures based on glycosylated [60]fullerenes linked to a central porphyrin scaffold have been designed and tested against DC-SIGN-mediated SARS-CoV-2 infection. First results show an outstanding inhibition of the trans-infection up to 90%. In addition, a deeper understanding of nanostructure-receptor binding is achieved through microscopy techniques, high-resolution NMR experiments, Quartz Crystal Microbalance experiments, and molecular dynamic simulations.
dc.description.departmentDepto. de Química Orgánica
dc.description.facultyFac. de Ciencias Químicas
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Ciencia, Innovación y Universidades (España)
dc.description.sponsorshipEuropean Commission
dc.description.statuspub
dc.identifier.citationPatino‐Alonso, Jennifer, et al. «C 60 ‐based Multivalent Glycoporphyrins Inhibit SARS‐CoV‐2 Specific Interaction with the DC‐SIGN Transmembrane Receptor». Small, vol. 20, n.o 19, mayo de 2024, p. 2307045. https://doi.org/10.1002/smll.202307045.
dc.identifier.doi10.1002/smll.202307045
dc.identifier.issn1613-6810
dc.identifier.officialurlhttps://doi.org/10.1002/smll.202307045
dc.identifier.urihttps://hdl.handle.net/20.500.14352/98371
dc.issue.number19
dc.journal.titleSmall
dc.language.isoeng
dc.page.initial2307045
dc.publisherWiley
dc.rights.accessRightsopen access
dc.subject.cdu547
dc.subject.ucmQuímica orgánica (Química)
dc.subject.unesco23 Química
dc.titleC60-based Multivalent Glycoporphyrins Inhibit SARS-CoV-2 Specific Interaction with the DC-SIGN Transmembrane Receptor
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number20
dspace.entity.typePublication
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