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Imaging the role of toll-like receptor 4 on cell proliferation and inflammation after cerebral ischemia by positron emission tomography

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dc.contributor.authorMoraga Yébenes, Ana
dc.contributor.authorGómez Vallejo, Vanessa
dc.contributor.authorCuartero Desviat, María Isabel
dc.contributor.authorSzczupak, Boguslaw
dc.contributor.authorSan Sebastián, Eneko
dc.contributor.authorMarkuerkiaga, Irati
dc.contributor.authorPradillo Justo, Jesús Miguel
dc.contributor.authorHiguchi, Makoto
dc.contributor.authorLlop, Jordi
dc.contributor.authorMoro Sánchez, María Ángeles
dc.contributor.authorMartín, Abraham
dc.contributor.authorLizasoaín Hernández, Ignacio
dc.date.accessioned2024-01-29T09:45:19Z
dc.date.available2024-01-29T09:45:19Z
dc.date.issued2016-01-19
dc.description.abstractThe influence of toll-like receptor 4 on neurogenesis and inflammation has been scarcely explored so far by using neuroimaging techniques. For this purpose, we performed magnetic resonance imaging and positron emission tomography with 3'-deoxy-3'-[(18)F]fluorothymidine and [(11)C]PK11195 at 2, 7, and 14 days following cerebral ischemia in TLR4(+/+)and TLR4(-/-)mice. MRI showed similar infarction volumes in both groups. Despite this, positron emission tomography with 3'-deoxy-3'-[(18)F]fluorothymidine and [(11)C]PK11195 evidenced an increase of neurogenesis and a decrease of inflammation in TLR4(-/-)mice after ischemia. These results evidence the versatility of neuroimaging techniques to monitor the role of toll-like receptor 4 after cerebral ischemia.
dc.description.departmentDepto. de Farmacología y Toxicología
dc.description.facultyFac. de Medicina
dc.description.refereedTRUE
dc.description.statuspub
dc.identifier.citationMoraga A, Gómez-Vallejo V, Cuartero MI, Szczupak B, San Sebastián E, Markuerkiaga I, Pradillo JM, Higuchi M, Llop J, Moro MÁ, Martín A, Lizasoain I. Imaging the role of toll-like receptor 4 on cell proliferation and inflammation after cerebral ischemia by positron emission tomography. J Cereb Blood Flow Metab. 2016 Apr;36(4):702-8. doi: 10.1177/0271678X15627657
dc.identifier.doi10.1177/0271678x15627657
dc.identifier.issn0271-678X
dc.identifier.issn1559-7016
dc.identifier.officialurlhttps://journals.sagepub.com/home/jcb
dc.identifier.pmidPMC4821030
dc.identifier.urihttps://hdl.handle.net/20.500.14352/95797
dc.issue.number4
dc.journal.titleJournal of Cerebral Blood Flow and Metabolism (JCBFM)
dc.language.isoeng
dc.page.final708
dc.page.initial702
dc.publisherSAGE Publications
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.cdu615.01/.03
dc.subject.keyword3′-deoxy-3′-[18F]fluorothymidine
dc.subject.keywordPositron emission tomography
dc.subject.keywordT2W-MRI
dc.subject.keyword[11C]PK11195
dc.subject.keywordCerebral ischemia
dc.subject.keywordMagnetic resonance imaging
dc.subject.keywordMiddle cerebral artery occlusion
dc.subject.keywordToll-like receptor 4
dc.subject.ucmCiencias Biomédicas
dc.subject.unesco32 Ciencias Médicas
dc.titleImaging the role of toll-like receptor 4 on cell proliferation and inflammation after cerebral ischemia by positron emission tomography
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number6
dspace.entity.typePublication
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