FGF receptor genes and breast cancer susceptibility: results from the Breast Cancer Association Consortium

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dc.contributor.authorAgarwal, Devika
dc.contributor.authorPineda Sanjuan, Silvia
dc.contributor.authorMichailidou, Kyriaki
dc.contributor.authorHerranz, J.
dc.contributor.authorPita, Guillermo
dc.contributor.authorMoreno, T.
dc.contributor.authorAlonso, M. R.
dc.contributor.authorDennis, Joe
dc.contributor.authorWang, Qin
dc.contributor.authorBolla, Manjeet
dc.contributor.authorMeyer, B.
dc.contributor.authorMenéndez Rodríguez, Primitiva
dc.contributor.authorHardisson, David
dc.contributor.authorMendiola, Marta
dc.contributor.authorGonzález-Neira, Anna
dc.contributor.authorLindblom, Annika
dc.contributor.authorMargolin, Sara
dc.contributor.authorSwerdlow, Anthony
dc.contributor.authorAshworth, Alan
dc.contributor.authorOrr, Nick
dc.contributor.authorJones, Michael
dc.contributor.authorMatsuo, Keitaro
dc.contributor.authorIto, Hidemi
dc.contributor.authorIwata, Hiroji
dc.contributor.authorKondo, Naoto
dc.contributor.authorHartman, Mikael
dc.contributor.authorHui, Miao
dc.contributor.authorLim, Wei Yee
dc.contributor.authorIau, P. T. C.
dc.contributor.authorSawyer, Elinor
dc.contributor.authorTomlinson, Ian
dc.contributor.authorKerin, Michael
dc.contributor.authorMiller, Nicola
dc.contributor.authorKang, Daehee
dc.contributor.authorChoi, Ji Yeob
dc.contributor.authorPark, Sue
dc.contributor.authorNoh, Dong Young
dc.contributor.authorHopper, John
dc.contributor.authorSchmidt, Daniel
dc.contributor.authorMakalic, Enes
dc.contributor.authorSouthey, Melissa
dc.contributor.authorTeo, Soo
dc.contributor.authorYip, Cheng Har
dc.contributor.authorSivanandan, K.
dc.contributor.authorTay, Tin
dc.contributor.authorBrauch, Hiltrud
dc.contributor.authorBrüning, Thomas
dc.contributor.authorHamann, Ute
dc.contributor.authorDunning, Alison
dc.contributor.authorShah, Mitul
dc.contributor.authorAndrulis, Irene
dc.contributor.authorKnight, Julia
dc.contributor.authorGlendon, Gord
dc.contributor.authorTchatchou, S.
dc.contributor.authorSchmidt, Marjanka
dc.contributor.authorBroeks, Annegien
dc.contributor.authorRosenberg, E. H.
dc.contributor.authorvan't Veer, L. J.
dc.contributor.authorFasching, Peter
dc.contributor.authorRenner, S. P.
dc.contributor.authorEkici, Arif
dc.contributor.authorBeckmann, Matthias
dc.contributor.authorShen, Chen Yang
dc.contributor.authorHsiung, Chia-Ni
dc.contributor.authorYu, Jy-Cherng
dc.contributor.authorBlot, William
dc.contributor.authorCai, Qiuyin
dc.contributor.authorWu, Anna
dc.contributor.authorTseng, Chiu-Chen
dc.contributor.authorVan Den Berg, David
dc.contributor.authorStram, Daniel
dc.contributor.authorCox, Angela
dc.contributor.authorBrock, Ian
dc.contributor.authorReed, Malcom
dc.contributor.authorMuir, Kenneth
dc.contributor.authorLophatananon, Artitaya
dc.contributor.authorStewart-Brown, Sarah
dc.contributor.authorSiriwanarangsan, P.
dc.contributor.authorZheng, Wei
dc.contributor.authorDeming Halverson, Sandra
dc.contributor.authorShrubsole, Martha
dc.contributor.authorLong, Jirong
dc.contributor.authorShu, Xiao-Ou
dc.contributor.authorLu, W
dc.contributor.authorGao, Yu-Tang
dc.contributor.authorZhang, B.
dc.contributor.authorRadice, Paolo
dc.contributor.authorPeterlongo, Paolo
dc.contributor.authorManoukian, Siranoush
dc.contributor.authorMariette, F.
dc.contributor.authorSangrajrang, Suleeporn
dc.contributor.authorMcKay, James
dc.contributor.authorCouch, Fergus
dc.contributor.authorToland, A. E.
dc.contributor.authorYannoukakos, D.
dc.contributor.authorFletcher, Olivia
dc.contributor.authorJohnson, Nicola
dc.contributor.authordos Santos Silva, I.
dc.contributor.authorPeto, Julian
dc.contributor.authorMarme, F
dc.contributor.authorBurwinkel, Barbara
dc.contributor.authorGuénel, Pascal
dc.contributor.authorTruong, Thérèse
dc.contributor.authorSánchez Beltrán, María Del Carmen
dc.contributor.authorMulot, Claire
dc.contributor.authorBojesen, Stig
dc.contributor.authorNordestgaard, Borge
dc.contributor.authorFlyer, H.
dc.contributor.authorBrenner, Hermann
dc.contributor.authorDieffenbach, A. K.
dc.contributor.authorArndt, Volker
dc.contributor.authorStegmaier, Christa
dc.contributor.authorMannermaa, Arto
dc.contributor.authorKataja, Vesa
dc.contributor.authorKosma, Veli-Matti
dc.contributor.authorHartikainen, Jaana
dc.contributor.authorLambrechts, Diether
dc.contributor.authorYesilyurt, B. T.
dc.contributor.authorFloris, G.
dc.contributor.authorLeunen, K.
dc.contributor.authorChang-Claude, Jenny
dc.contributor.authorRudolph, Anja
dc.contributor.authorSeibold, P.
dc.contributor.authorFlesch-Janys, Dieter
dc.contributor.authorWang, X.
dc.contributor.authorOlson, Janet
dc.contributor.authorVachon, Celine
dc.contributor.authorPurrington, K.
dc.contributor.authorGiles, Graham
dc.contributor.authorSeveri, G.
dc.contributor.authorBaglietto, L.
dc.contributor.authorHaiman, Christopher
dc.contributor.authorHenderson, B. E.
dc.contributor.authorSchumacher, Fredrick
dc.contributor.authorMarchand, Loïc Le
dc.contributor.authorSimard, Jacques
dc.contributor.authorDumont, Martine
dc.contributor.authorGoldberg, Mark
dc.contributor.authorLabréche, F.
dc.contributor.authorWinqvist, Robert
dc.contributor.authorPylkäs, Katri
dc.contributor.authorJukkola-Vuorinen, Arja
dc.contributor.authorGrip, Mervi
dc.contributor.authorDevilee, Peter
dc.contributor.authorTollenaar, Rob
dc.contributor.authorSeynaeve, Caroline
dc.contributor.authorGarcía-Closas, Montserrat
dc.contributor.authorChanock, Stephen
dc.contributor.authorLissowska, Jolanta
dc.contributor.authorFigueroa, Jonine
dc.contributor.authorCzene, Kamila
dc.contributor.authorEriksson, Mikael
dc.contributor.authorHumphreys, Keith
dc.contributor.authorDarabi, H.
dc.contributor.authorHooning, Maartje
dc.contributor.authorKriege, Margriet
dc.contributor.authorCollée, Margriet
dc.contributor.authorTilanus-Linthorst, M.
dc.contributor.authorLi, Jingmei
dc.contributor.authorJakubowska, Anna
dc.contributor.authorLubinski, Jan
dc.contributor.authorJaworska-Bieniek, K.
dc.contributor.authorDurda, K
dc.contributor.authorNevanlinna, Heli
dc.contributor.authorMuranen, T. A.
dc.contributor.authorAittomäki, Kristiina
dc.contributor.authorBlomqvist, Carl
dc.contributor.authorBogdanova, Natalia
dc.contributor.authorDörk, Thilo
dc.contributor.authorHall, Per
dc.contributor.authorChenevix-Trench, Georgia
dc.contributor.authorEaston, Douglas
dc.contributor.authorPharroah, Paul
dc.contributor.authorArias-Perez, José Ignacio
dc.contributor.authorZamora, P.
dc.contributor.authorBenítez, Javier
dc.contributor.authorMilne, Roger
dc.contributor.editorEvans, Jeff
dc.date.accessioned2024-01-09T15:09:24Z
dc.date.available2024-01-09T15:09:24Z
dc.date.issued2014
dc.description.abstractBackground: Breast cancer is one of the most common malignancies in women. Genome-wide association studies have identified FGFR2 as a breast cancer susceptibility gene. Common variation in other fibroblast growth factor (FGF) receptors might also modify risk. We tested this hypothesis by studying genotyped single-nucleotide polymorphisms (SNPs) and imputed SNPs in FGFR1, FGFR3, FGFR4 and FGFRL1 in the Breast Cancer Association Consortium. Methods: Data were combined from 49 studies, including 53 835 cases and 50 156 controls, of which 89 050 (46 450 cases and 42 600 controls) were of European ancestry, 12 893 (6269 cases and 6624 controls) of Asian and 2048 (1116 cases and 932 controls) of African ancestry. Associations with risk of breast cancer, overall and by disease sub-type, were assessed using unconditional logistic regression. Results: Little evidence of association with breast cancer risk was observed for SNPs in the FGF receptor genes. The strongest evidence in European women was for rs743682 in FGFR3; the estimated per-allele odds ratio was 1.05 (95% confidence interval=1.02–1.09, P=0.0020), which is substantially lower than that observed for SNPs in FGFR2. Conclusion: Our results suggest that common variants in the other FGF receptors are not associated with risk of breast cancer to the degree observed for FGFR2.en
dc.description.departmentDepto. de Estadística y Ciencia de los Datos
dc.description.facultyFac. de Estudios Estadísticos
dc.description.refereedTRUE
dc.description.statuspub
dc.identifier.citationAgarwal, D., Pineda Sanjuan, S., Michailidou, K. et al. «FGF Receptor Genes and Breast Cancer Susceptibility: Results from the Breast Cancer Association Consortium». British Journal of Cancer, vol. 110, n.o 4, febrero de 2014, pp. 1088-100. www.nature.com, https://doi.org/10.1038/bjc.2013.769.
dc.identifier.doi10.1038/bjc.2013.769
dc.identifier.essn1532-1827
dc.identifier.issn0007-0920
dc.identifier.officialurlhttps://www.doi.org/10.1038/bjc.2013.769
dc.identifier.relatedurlhttp://www.nature.com/bjc
dc.identifier.urihttps://hdl.handle.net/20.500.14352/92074
dc.issue.number4
dc.journal.titleBritish Journal of Cancer
dc.language.isoeng
dc.page.final1100
dc.page.initial1088
dc.publisherSpringer Nature
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.cdu519.2:61
dc.subject.cdu616-006.04
dc.subject.cdu575
dc.subject.keywordBreast cancer
dc.subject.keywordSNP
dc.subject.keywordFGF receptors
dc.subject.keywordSusceptibility
dc.subject.keywordDisease subtypes
dc.subject.ucmBiomatemáticas
dc.subject.ucmOncología
dc.subject.ucmGenética
dc.subject.unesco2404.01 Bioestadística
dc.subject.unesco3201.01 Oncología
dc.subject.unesco2409 Genética
dc.titleFGF receptor genes and breast cancer susceptibility: results from the Breast Cancer Association Consortiumen
dc.typejournal article
dc.type.hasVersionAM
dc.volume.number110
dspace.entity.typePublication
relation.isAuthorOfPublication9ff02bb9-3623-452e-ad72-8bb19687ec4e
relation.isAuthorOfPublication27fce85c-05b6-4420-b0a4-22ef8510f4e2
relation.isAuthorOfPublication.latestForDiscovery9ff02bb9-3623-452e-ad72-8bb19687ec4e

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