Influence of Carbon Nanosheets on the Behavior of 1,2-Dipalmitoyl-sn-glycerol-3-phosphocholine Langmuir Monolayers

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dc.contributor.authorMuñoz López, Ruth
dc.contributor.authorGuzmán Solís, Eduardo
dc.contributor.authorVelázquez, Maria Mercedes
dc.contributor.authorFernández Peña, Laura
dc.contributor.authorMerchán, María Dolores
dc.contributor.authorMaestro, Armando
dc.contributor.authorOrtega Gómez, Francisco
dc.contributor.authorGonzález Rubio, Ramón
dc.date.accessioned2023-06-17T09:09:19Z
dc.date.available2023-06-17T09:09:19Z
dc.date.issued2020-01-10
dc.description.abstractCarbon nanomaterials are widespread in the atmospheric aerosol as a result of the combustion processes and their extensive industrial use. This has raised many question about the potential toxicity associated with the inhalation of such nanoparticles, and its incorporation into the lung surfactant layer. In order to shed light on the main physical bases underlying the incorporation of carbon nanomaterials into lung surfactant layers, this work has studied the interaction at the water/vapor interface of carbon nanosheets (CN) with Langmuir monolayers of 1,2-Dipalmitoyl-sn-glycerol-3-phosphocholine (DPPC), with this lipid being the main component of lung surfactant layers and responsible of some of the most relevant features of such film. The incorporation of CN into DPPC Langmuir monolayers modifies the lateral organization of the DPPC at the interface, which is explained on the basis of two different effects: (i) particles occupy part of the interfacial area, and (ii) impoverishment of the lipid composition of the interface due to lipid adsorption onto the CN surface. This results in a worsening of the mechanical performance of the monolayers which may present a negative impact in the physiological performance of lung surfactant. It would be expected that the results obtained here can be useful as a step toward the understanding of the most fundamental physico-chemical bases associated with the effect of inhaled particles in the respiratory cycle.
dc.description.departmentDepto. de Química Física
dc.description.facultyFac. de Ciencias Químicas
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Economía y Competitividad (MINECO)
dc.description.sponsorshipBanco Santander/Universidad Complutense de Madrid
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/66786
dc.identifier.doi10.3390/pr8010094
dc.identifier.issn2227-9717
dc.identifier.officialurlhttps://doi.org/10.3390/pr8010094
dc.identifier.relatedurlhttps://www.mdpi.com/2227-9717/8/1/94
dc.identifier.urihttps://hdl.handle.net/20.500.14352/8289
dc.issue.number1
dc.journal.titleProcesses
dc.language.isoeng
dc.page.initial94
dc.publisherMDPI
dc.relation.projectIDCTQ2016-78895-R
dc.relation.projectIDPR87/19-22513
dc.rightsAtribución 3.0 España
dc.rights.accessRightsopen access
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/es/
dc.subject.keywordparticles
dc.subject.keywordlipids
dc.subject.keywordLangmuir monolayer
dc.subject.keywordlung surfactant
dc.subject.keywordpollution
dc.subject.keyworddilational rheology
dc.subject.keywordtoxicity
dc.subject.keywordcarbon nanosheets
dc.subject.ucmQuímica física (Física)
dc.subject.ucmQuímica física (Química)
dc.subject.unesco2210 Química Física
dc.titleInfluence of Carbon Nanosheets on the Behavior of 1,2-Dipalmitoyl-sn-glycerol-3-phosphocholine Langmuir Monolayers
dc.typejournal article
dc.volume.number8
dspace.entity.typePublication
relation.isAuthorOfPublication8461433f-f4e7-40b0-9549-b14c34817028
relation.isAuthorOfPublication868be429-b538-45d8-a4c1-e1fac224c804
relation.isAuthorOfPublicationffe9a2c2-caca-446f-a49e-14cacb7984df
relation.isAuthorOfPublication.latestForDiscovery868be429-b538-45d8-a4c1-e1fac224c804
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