Tailoring the biological response of mesoporous bioactive materials

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dc.contributor.authorGómez Cerezo, María Natividad
dc.contributor.authorIzquierdo Barba, Isabel
dc.contributor.authorArcos Navarrete, Daniel
dc.contributor.authorVallet Regí, María Dulce Nombre
dc.date.accessioned2024-01-25T16:15:40Z
dc.date.available2024-01-25T16:15:40Z
dc.date.issued2013
dc.description.abstractSilica mesoporous nanomaterials have been proved to have meaningful application in biotechnology and biomedicine. Particularly, mesoporous bioactive glasses are recently gaining importance thanks to their bone regenerative properties. Moreover, the mesoporous nature of these materials makes them suitable for drug delivery applications, opening new lines in the field of bone therapies. In this work, we have developed innovative nanodevices based on the implementation of adenosine triphosphate (ATP) and ε-poly-l-lysine molecular gates using a mesoporous bioglass as an inorganic support. The systems have been previously proved to work properly with a fluorescence probe and subsequently with an antibiotic (levofloxacin) and an antitumoral drug (doxorubicin). The bioactivity of the prepared materials has also been tested, giving promising results. Finally, in vitro cell culture studies have been carried out; demonstrating that this gated devices can provide useful approaches for bone cancer and bone infection treatments.
dc.description.departmentDepto. de Química en Ciencias Farmacéuticas
dc.description.facultyFac. de Farmacia
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Ciencia e Innovacion (España)
dc.description.sponsorshipMinisterio de Economía y Competitividad (España)
dc.description.sponsorshipAgening Network of Excellence
dc.description.statuspub
dc.identifier.citationGómez-Cerezo N, Izquierdo-Barba I, Arcos D, Vallet-Regí M. Tailoring the biological response of mesoporous bioactive materials. J Mater Chem B 2015;3:3810–9. https://doi.org/10.1039/C5TB00268K.
dc.identifier.doi10.1039/C5TB00268K
dc.identifier.essn2050-7518
dc.identifier.issn2050-750X
dc.identifier.officialurlhttps://doi.org/10.1039/C5TB00268K
dc.identifier.urihttps://hdl.handle.net/20.500.14352/95544
dc.journal.titleJournal of Materials Chemistry B
dc.language.isoeng
dc.publisherElsevier
dc.relation.projectIDMAT2012-35556
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//MAT2013-43299-R/ES/ESTRUCTURAS MACROPOROSAS ASOCIADAS A FACTORES DE CRECIMIENTO PARA LA RECONSTRUCCION DE DEFECTOS OSEOS Y DEFECTOS EN HUESO OSTEOPOROTICO/
dc.relation.projectIDinfo:eu-repo/grantAgreement/MICINN//CSO2010-11384-E/ES/ENVEJECIMIENTO: RED DE EXCELENCIA ESPAÑOLA Y EUROPEA PARA LA PREVENCION Y TRATAMIENTO LOCAL DE FRACTURAS OSTEOPOROTICAS/
dc.rights.accessRightsrestricted access
dc.subject.cdu615:54
dc.subject.cdu615.31
dc.subject.ucmQuímica farmaceútica
dc.subject.unesco23 Química
dc.titleTailoring the biological response of mesoporous bioactive materials
dc.typejournal article
dc.type.hasVersionAM
dc.volume.number18
dspace.entity.typePublication
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relation.isAuthorOfPublicationee9272a2-db11-4efb-97f8-7ce1a18ad55e
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relation.isAuthorOfPublication.latestForDiscovery791023b8-2531-44eb-ba01-56e3b7caa0cb
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