Characterization of corneal impression cyotology in dogs and its application in the diagnosis of keratoconjunctivitis sicca

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dc.contributor.authorLejarza Illaro, Mikel
dc.contributor.authorRodríguez Álvaro, Alfonso
dc.contributor.authorSánchez Maldonado, María Belén
dc.contributor.authorGonzález Alonso-Alegre, Elisa-Margarita
dc.date.accessioned2024-02-01T11:26:50Z
dc.date.available2024-02-01T11:26:50Z
dc.date.issued2019
dc.description.abstractObjective: Determine morphological and morphometric parameters of corneal epithelium in dogs, and determine the cellular alterations that occur in canine keratoconjunctivitis sicca (KCS) using impression cytology. Study animals: 60 dogs divided into 2 groups: dogs with Schirmer tear test (STT) ≥ 15 mm/min and absence of ocular disease, and dogs with STT < 15 mm/min and clinical signs of KCS. Procedures: Impression cytology was used to collect corneal samples. The percentage of eyes with cell changes, the number of such cells and the percentage of cells with structural alterations in each group were determined. The possible correlation between corneal epithelium alterations and decreased tear production was evaluated. Results: A significant positive correlation existed between STT and the area of the cytoplasm and nucleus of corneal cells. A significant negative correlation was found between STT and the nucleus/cytoplasm (N:C) ratio, and the presence of cellular changes. Significant difference existed between the number of pyknotic nuclei, being higher among animals with all stages of KCS. Conclusion: Corneal impression cytology can be used to assess the corneal epithelium in healthy eyes and eyes with KCS, demonstrating its usefulness as a diagnostic tool especially in mild and early cases.
dc.description.departmentDepto. de Medicina y Cirugía Animal
dc.description.facultyFac. de Veterinaria
dc.description.refereedTRUE
dc.description.statuspub
dc.identifier.citationLejarza-Ilaro, M., Rodriguez-Alvaro, A., Sanchez-Maldonado, B., & Gonzalez-Alonso-Alegre, E. (2019). Characterisation of corneal impression cytology in dogs and its application in the diagnosis of keratoconjunctivitis sicca. The Veterinary record, 184(22), 678. https://doi.org/10.1136/vr.105003
dc.identifier.doi10.1136/vr.105003
dc.identifier.essn2042-7670
dc.identifier.issn0042-4900
dc.identifier.officialurlhttps://doi.org/10.1136/vr.105003
dc.identifier.pmid31019006
dc.identifier.relatedurlhttps://bvajournals.onlinelibrary.wiley.com/doi/10.1136/vr.105003
dc.identifier.urihttps://hdl.handle.net/20.500.14352/97594
dc.issue.number22
dc.journal.titleThe Veterinary Record
dc.language.isoeng
dc.page.initial678
dc.publisherWiley
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.accessRightsrestricted access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.cdu636.09:617.7
dc.subject.keywordMillipore
dc.subject.keywordCanine
dc.subject.keywordCornea
dc.subject.keywordCorneal epithelium
dc.subject.keywordDiagnosis
dc.subject.keywordDry eye
dc.subject.ucmVeterinaria
dc.subject.unesco3201.09 Oftalmología
dc.titleCharacterization of corneal impression cyotology in dogs and its application in the diagnosis of keratoconjunctivitis sicca
dc.title.alternativeCaracterización de la citología de impresión corneal en perros y su aplicación en el diagnóstico de la queratoconjuntivitis seca
dc.typejournal article
dc.type.hasVersionAM
dc.volume.number184
dspace.entity.typePublication
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relation.isAuthorOfPublication59ec3833-8ed6-447c-8655-b605e7aa593a
relation.isAuthorOfPublication4027b097-f516-461e-86a1-c5b3cbfdaa9b
relation.isAuthorOfPublication.latestForDiscovery4027b097-f516-461e-86a1-c5b3cbfdaa9b
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